Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi’an, China, December 8, 2021, to January 20, 2022: A retrospective studyArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] addition Admission analyzed attenuate blood biochemical Blood routine CD8 China Clinical features coagulation function coagulative collected COVID-19 dose doses Effectiveness elevated eosinophil eosinophils Epidemic evaluate had no Hospitalized IgG IgG level Kidney function Laboratory laboratory data laboratory findings liver lymphocyte Lymphocytes moderate Patient patients patients hospitalized percentage proportion Protective Retrospective study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine severe symptom significantly specific antibody Subtypes symptoms of COVID-19 T cell T-lymphocytes the vaccine vaccination Vaccine vaccine dose virus with COVID-19 [DOI] 10.3389/fimmu.2022.978977 PMC 바로가기
Intranasal immunization with recombinant Vaccinia virus encoding trimeric SARS-CoV-2 spike receptor-binding domain induces neutralizing antibodyArticle Published on 2022-09-222022-11-15 Journal: Vaccine [Category] SARS, 진단, 치료기술, [키워드] BALB/c mice Bronchoalveolar lavage fluid cellular immune responses COVID-19 detectable dissemination domain Effects elicited evaluated exhibited expressing humoral IgA IgG immune response immunization immunized induce Infection intranasal Lymphocytes mice mucosal mucosal immune nasal washe neutralization neutralization activities Neutralizing Neutralizing antibodies neutralizing antibody RBD respiratory response robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein secretory IgA sera systemic immune response transmission of SARS-CoV-2 trimeric trimeric RBD Vaccine vaccinia vaccinia virus virus [DOI] 10.1016/j.vaccine.2022.08.054 PMC 바로가기
Humoral immunoresponse elicited against an adenoviral-based SARS-CoV-2 coronavirus vaccine in elderly patientsArticle Published on 2022-09-212022-11-15 Journal: Aging (Albany NY) [Category] SARS, 진단, 치료기술, [키워드] Ad26 Ad5 analyzed anti-RBD anti-RBD ELISA anti-RBD IgG antibodies antibody Cohort COVID-19 detectable dose dropped effective vaccine elderly Elderly patient elicit elicited Evolution expected females Gam-COVID-Vac Gender Genome Heterologous highest humoral immune response IgG IgG titer immune response immune responses immune system individual median post vaccination reached remained robust SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection Sequencing seroconversion rate significant decrease significant difference specific antibody the SARS-CoV-2 the Spike Vaccine viral genome virus Volunteer [DOI] 10.18632/aging.204299 PMC 바로가기
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)Article Published on 2022-09-212022-11-15 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] age analyzed anti-SARS-CoV-2 Anti-spike Antiretroviral therapy black BNT162b2 booster CD4 CD8 cells clinically COVID-19 COVID-19 vaccination COVID-19 vaccine decrease demographics detectable dose exploratory female HIV Humoral immunity IgG IgG levels immune response immunogenicity majority male marker median MOST occurred offered Older outcome participant positive presenting primary analysis protective immunity quantitative assessment reactogenicity recruited responses SARS-CoV-2 secondary single-center Spike protein subject suppressed T-cell T-cell Response vaccination Viremia virus-specific T-cell response white Wilcoxon signed-rank test with HIV [DOI] 10.1186/s12879-022-07737-0 PMC 바로가기
Safety and immunogenicity of 3 doses of BNT162b2 and CoronaVac in children and adults with inborn errors of immunityArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] age Antibody Response BNT162b2 children CoronaVac COVID-19 determine dose flow cytometry homologous Hong Kong humoral IgG IgG response Immunity immunodeficiency inactivated Inadequate inborn errors of immunity include intracellular cytokine staining Intradermal intramuscular mRNA vaccine neutralization nonrandomized of BNT162b2 omicron Patient patients receiving response S-RBD Safety SARS-CoV-2 antigen T cell response Two patient vaccination Vaccine Virus neutralization [DOI] 10.3389/fimmu.2022.982155 PMC 바로가기
Saliva is suitable for SARS-CoV-2 antibodies detection after vaccination: A rapid systematic reviewArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] 95% CI Ad26 analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination antibodies antibody Antibody detection Antibody titer applied assays AstraZeneca convalescent individual correlation COVID-19 COVID-19 vaccines eligible ELISA assay evaluate flow cytometry highlight IgA IgG Immunity immunoassay Immunoglobulin immunological increasingly infected individuals janssen Johnson & Johnson lack moderate mRNA-based mucosal Neutralizing nine quantification reached reported Saliva salivary SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 detection selected serological test serum serum/plasma systematic review vaccinated individual vaccination Vaccination strategy Vaccine Web of Science [DOI] 10.3389/fimmu.2022.1006040 PMC 바로가기
Identification and characterization of a novel cell binding and cross-reactive region on spike protein of SARS-CoV-2Article Published on 2022-09-192022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] addition amino acid sequence Antisera Beas-2B cells binding Cell characterized conserved COVID-19 Cross reactivity cross-reactive develop effective vaccine Escherichia coli evade full-length Host host cell identification IgG immune imperative in viral Infection inhibited involved murine Mutation mutations neutralizing monoclonal antibody observation Prevent produced pseudovirus purified Recombinant protein S protein S-protein SARS-CoV SARS-CoV-2 Serologically Spike protein virus virus variant [DOI] 10.1038/s41598-022-19886-y PMC 바로가기
Antibody dynamics post-Comirnaty and CoronaVac vaccination in MalaysiaArticle Published on 2022-09-192022-11-15 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] analyzed antibody blood sample clinical trial CoronaVac correlation detectable East effective IgG IgM independent magnitude Malaysia mitigate moderate neutralizing antibody pandemic progression recipient recipients responses Result SARS-CoV-2 vaccination second dose serum serum vitamin D significantly higher subset the patient vaccination Vaccine Vaccines [DOI] 10.1038/s41598-022-19776-3 PMC 바로가기
COVID-19 cross-sectional study in Maricá, Brazil: The impact of vaccination coverage on viral incidenceArticle Published on 2022-09-192022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 진단, 치료기술, [키워드] anti-SARS-CoV-2 Brazil correlated Coverage COVID-19 cross-sectional delta variant detectable disease greater group highlighting IgG IgG antibody Immunity immunological incidence incidence of COVID-19 individual neutralizing antibody occurred performed Population proportion Rio de Janeiro SARS-CoV-2 subjects Support Surveillance Transmission vaccinated individual vaccination Vaccine variant widespread [DOI] 10.1371/journal.pone.0269011 PMC 바로가기
SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concernArticle Published on 2022-09-182022-10-06 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor Transmission utilised vaccination Vaccine variant viral lineage viral variant [DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article