innate immune response – Page 18 – Communicable Diseases Research

Neutrophil Maturation, Reactivity and Granularity Research Parameters to Characterize and Differentiate Convalescent Patients from Active SARS-CoV-2 Infection

Article

Published on 2021-09-062022-10-31
Journal: Cells [Category] COVID-19,

Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

Article

Published on 2021-09-022022-10-30
Journal: Molecules [Category] Coronavirus, SARS,

[키워드] chronic condition chronic obstructive cleaved COPD Critical discrimination disorder Elastase form Host host tissue Human human neutrophil elastase increase Infection inhibitor innate immune response invading pathogens Lung injury mechanism methionine methionine oxidation methionine sulfone neutrophil Neutrophil elastase neutrophil recruitment Neutrophils observation other proteases oxidative pathogen pathogen clearance pathway peptide aldehyde preference probe proteolytic activity pulmonary disease reduce residue responsible selected selective serine protease solvent substrate substrate guided inhibitor design substrate selectivity Sulfone Sulfoxide These data tissue tissue damage while with COVID-19
[DOI] 10.3390/molecules26175344 PMC 바로가기 [Article Type] Article

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

선천성 면역 반응을 조절하는 SARS-CoV-2 뉴클레오캡시드 단백질의 이중 역할

Article

Published on 2021-09-012022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료법,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 causative agent contribute coronavirus COVID-19 Cytokines demonstrated early stage effective strategy global pandemic High-dose IFN-I IFN-I signaling immune response immune responses Immunosuppression Infection Inflammatory cytokines innate immune response innate immune responses Innate immunity IRF3 late stage low-dose mechanism N protein nuclear translocation nucleocapsid overactive Pathogenesis pathogenesis of SARS-CoV-2 Phosphorylation promoted Protein regulated Regulatory respiratory retinoic acid retinoic acid-inducible gene I RIG-I SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-like coronaviruses severe acute respiratory syndrome Coronavirus Signaling Stat1 STAT2 suppress suppressed the SARS-CoV-2 Trigger TRIM25 type I interferon
[DOI] 10.1038/s41392-021-00742-w PMC 바로가기 [Article Type] Article

Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose

급성 SARS-CoV-2 감염은 코의 녹농균(Pseudomonas aeruginosa)을 비롯한 세균성 병원체의 풍부함 증가와 관련이 있습니다

Article

Published on 2021-08-312022-09-11
Journal: Cell Reports [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Bacterial infections bacterial pathogen Bacterial pathogens caused Coinfection conducted contribute coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 Diagnosis epithelia healthcare worker host response Host transcriptional response incidence Infection Inflammation Inflammatory response innate immune response Microbiome nasal Nasal cavity nasal microbiome neuronal observé Outpatient Pathogenesis Pathogens patients Pseudomona Pseudomonas aeruginosa RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-positive patient SARS-CoV-2-positive patients Secondary bacterial infections severe acute respiratory syndrome Coronavirus severely ill patients These data unique viral RNA load
[DOI] 10.1016/j.celrep.2021.109637 PMC 바로가기 [Article Type] Article

Molecular and Structural Parallels between Gluten Pathogenic Peptides and Bacterial-Derived Proteins by Bioinformatics Analysis

생물정보학 분석을 통한 글루텐 병원성 펩타이드와 박테리아 유래 단백질 간의 분자 및 구조적 유사성

Article

Published on 2021-08-272024-07-30
Journal: International Journal of Molecular Sciences [Category] 폐렴구균 감염증,

[키워드] 33-mer peptide celiac disease gliadin epitopes innate immune response non-celiac gluten sensitivity p31-43 peptide Pathogens sequence similarity SH3 and WW domains
[DOI] 10.3390/ijms22179278 PMC 바로가기 [Article Type] Article

Host Antiviral Responses against Avian Infectious Bronchitis Virus (IBV): Focus on Innate Immunity

Review

Published on 2021-08-262022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues

SARS-CoV-2는 수지상 세포를 손상시키고 조직에서 DC-SIGN 유전자 발현을 조절합니다

Article

Published on 2021-08-262022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단,

Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors

Review

Published on 2021-08-262023-05-25
Journal: International Journal of Molecular Sciences [Category] E형 간염, Fulltext,

[키워드] hepatitis E virus Inflammation innate immune response interferon interferon-stimulated genes Pattern recognition receptors
[DOI] 10.3390/ijms22179259 PMC 바로가기 [Article Type] Review

Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses

Article

Published on 2021-08-252022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] activated Cell Cell Biology cell lines Comparative Computational biology and bioinformatics COVID-19 disease Critical disease status Diseases Endoplasmic reticulum Express expression level hACE2 HEK293T cell Host Host immune response human Angiotensin-converting enzyme immune attack immune response immune responses immunology infected cell Infection Infection route innate immune response mechanism Microbiology model system Molecular biology overexpress Pathogenesis pathway progression Protein provided reflect reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severity of COVID-19 Stress Systems biology Transcriptome transcriptomic analysis triggering Viral load virus
[DOI] 10.1038/s41598-021-96462-w PMC 바로가기 [Article Type] Article