Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug targetArticle Published on 2022-06-142024-08-29 Journal: Cell Reports [Category] 말라리아, [키워드] Artemisinin CP: Metabolism CP: Microbiology endocytosis hemoglobin host cell cytosol uptake lipid peroxidation malaria molecular parasitology oxidative stress Plasmodium falciparum Prdx6
Athletes’ Mesenchymal Stem Cells Could Be the Best Choice for Cell Therapy in Omicron-Infected Patients운동선수의 중간엽 줄기세포는 오마이크론에 감염된 환자의 세포 치료를 위한 최선의 선택이 될 수 있습니다Article Published on 2022-06-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar anti-apoptotic Anti-inflammatory antioxidant athlete Breakthrough infection breakthrough infections caused Cell cell survival choice coronavirus COVID-19 Cytokines Defense defense mechanisms effective epithelial cells exercise growth growth rate growth signaling highlight immunomodulatory incidence Inflammation Ischemia mechanism microenvironment Mutation New omicron outcome oxidative stress patients Re-infections reduce reduced respiratory epithelial cell respiratory epithelial cells SARS-CoV-2 secretion sport STEM stem cell stem cells stem-cell therapy suggested Support survival therapy transplantation Treatment Vaccine variant variants [DOI] 10.3390/cells11121926 PMC 바로가기 [Article Type] Article
Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?COVID-19 관리를 위한 Artemisia 추출물 및 Artemisinin 기반 항말라리아제: 이것이 COVID-19 치료에 효과적인 항바이러스제일 수 있습니까?Review Published on 2022-06-142022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 말라리아, 신약개발, 치료제, [키워드] active against acts acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Anti-inflammatory effects Antiviral Artemisia Artemisinin artemisinins combination therapies coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated derivative derivatives Drug repurposing Effect Effectiveness Evidence exhibit Extract IL-6 Infection Inflammation inhibiting interleukin-6 Invasion lung damage malaria other diseases oxidative stress pandemic positive reducing Replication SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 shown Symptoms the SARS-CoV-2 treat Treatment [DOI] 10.3390/molecules27123828 PMC 바로가기 [Article Type] Review
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications Reviews Published on 2022-06-132022-10-05 Journal: Nature reviews. Cardiology [Category] 유전자 메커니즘, [키워드] activated Activation addition adipose advance Arrhythmias Atherosclerosis biological processes canonical cardiovascular disease cardiovascular system Cell complex component Diseases Effect Endothelial dysfunction fibrosis gene silencing heart failure implication include involved Ligand macrophage activation main mechanism mechanism monoclonal antibodies Myocardial obesity oxidative stress pathway Pathways phenotype receptors Regulation review RNA substantial risk therapeutic therapeutic potential therapeutic targeting tissue Treatment tumorigenesis Vascular vascular smooth muscle β-catenin [DOI] 10.1038/s41569-022-00718-5 [Article Type] Reviews
Revealing the toxicity of lopinavir- and ritonavir-containing water and wastewater treated by photo-induced processes to Danio rerio and Allivibrio fischeriDanio rerio 및 Allivibrio fischeri에 광유도 공정으로 처리된 로피나비르 및 리토나비르 함유 용수 및 폐수의 독성 공개Article Published on 2022-06-102022-09-11 Journal: The Science of the total environment [Category] 치료제, [키워드] Affect affecting antiviral drug antiviral drugs Bacteria Behavior Chronic toxicity Concentration Contact contact with coronavirus disease Coronavirus disease 2019 COVID-19 Danio drug Ecotoxicity edema Efficiency form hospital Impact increase in indicate Inflammation Lopinavir LOPINAVIR AND RITONAVIR Organisms oxidative stress oxygen parameter Photocatalysis Photolysis physicochemical plants predicted problem protocols reduce Ritonavir shortening significantly survival tail toxic effect Toxicity treated Treatment wastewater water zebrafish [DOI] 10.1016/j.scitotenv.2022.153967 PMC 바로가기 [Article Type] Article
How to Restore Oxidative Balance That Was Disrupted by SARS-CoV-2 InfectionSARS-CoV-2 감염으로 교란된 산화 균형을 회복하는 방법Review Published on 2022-06-072022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin antioxidant antioxidants Antioxidative balance caused Clinical studies clinical study complex coronavirus coronavirus 2019 disease Course COVID-19 COVID-19 pathogenesis cytokine Cytokine storm demonstrated detrimental disease Disrupted drug dysregulated Effect expression glutathione GSH homeostasis Immunological response Impact induce Inflammasome inflammasomes inhibit mechanism NLRP3 Nrf2 nuclear outcome oxidative oxidative stress oxygen Prevent Protective Protein protein 3 reactive oxygen species reactive oxygen specy Renin renin angiotensin system ROS SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown stimulate the disease variant variety virus [DOI] 10.3390/ijms23126377 PMC 바로가기 [Article Type] Review
A spotlight on HCV and SARS-CoV-2 co-infection and brain functionArticle Published on 2022-06-012023-07-09 Journal: Pharmacology Biochemistry and Behavior [Category] COVID19(2023년), [키워드] Blood brain barrier Cognition Cytokines Inflammation mood oxidative stress [DOI] 10.1016/j.pbb.2022.173403 PMC 바로가기
Oxidative stress and endogenous DNA damage in blood mononuclear cells may predict anti-SARS-CoV-2 antibody titers after vaccination in older adults혈액 단핵 세포의 산화 스트레스와 내인성 DNA 손상은 노인에서 예방 접종 후 항 SARS-CoV-2 항체 역가를 예측할 수 있습니다Article Published on 2022-06-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 치료기술, [키워드] age All participants anti-S anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Anti-spike antibodies antibody Biomarker Biomarkers Blood BNT162b2 circulating correlated DNA DNA damage DNA damage response double-strand break DSBs Efficacy Efficiency first dose genomic humoral immune response Humoral response humoral responses Hypothesis IgG antibodies Immune cell immune cells immune senescence increase in Increased individual inverse correlation mononuclear cell mRNA vaccination neutralizing capacity Older oxidative oxidative stress Participants Peripheral blood Peripheral blood mononuclear cells pre-vaccination predict SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination second dose Stress tested titers vaccination Vaccine vaccine efficacy [DOI] 10.1016/j.bbadis.2022.166393 PMC 바로가기 [Article Type] Article
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19Research article Published on 2022-06-012022-10-05 Journal: Medical Hypotheses [Category] 변종, 유전자 메커니즘, [키워드] AGMO approach Clinical treatment deficiencies deficiency exhibited Ferroptosis GCH1 GCH1 mutations GTP heterozygous homozygous mutation hyperinflammatory state impair Inflammatory initial innate immune system involved less manuscript Marginal Marginally deficient BH4 metabolic processe Mutation nitric oxide organ systems organs oxidative stress Oxide PASC Post-acute sequelae of COVID-19 (PASC) resulting SARS-CoV-2 symptomatic Synthase tetrahydrobiopterin the patient Treatment Uncoupling iNOS [DOI] 10.1016/j.mehy.2022.110842 [Article Type] Research article
A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies투과성 연구에서 나노제형을 사용하여 적용된 COVID-19 약물 몰누피라비르의 측정을 위한 안정성을 나타내는 RP-HPLC 방법Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral drugs applied Caco-2 calculated candidate cell line column conditions Coronavirus-2 Council COVID-19 demonstrated drug drug candidate drug delivery system flow rate homogeneity ICH in vitro Infection linear molnupiravir N4-hydroxycytidine nucleoside optimization oxidative stress pandemic peak permeability prodrug quantitation robust RP-HPLC SARS-CoV-2 SARS-CoV-2 treatment selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specificity stability validation was performed was used water [DOI] 10.1016/j.jpba.2022.114693 PMC 바로가기 [Article Type] Article