The regulation of the mitochondrial apoptotic pathway by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cellsT 세포 발달에서 Bcl-2 계열 단백질과 협력하여 글루코코르티코이드 수용체에 의한 미토콘드리아 세포 사멸 경로의 조절The Many Ways of Apoptotic Cell Death Published on 2016-11-262022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] accumulated activated Activation active caspase-3 alternative Apoptosis apoptotic pathway apoptotic pathways apoptotic signaling association Bax BCL-2 Bcl-2 family Bcl-2 family protein Bcl-2 proteins Bcl-x Bim caspase-3 caspase-8 caspase-9 CD4 CD8 classical Combination cross-talk Cytochrome C demonstrated Dexamethasone early phase event genomic glucocorticoid Glucocorticoid hormone Glucocorticoid receptor glucocorticoid receptor (GR Glucocorticoids Hypothesis in vitro Interaction investigated involved mice Mitochondria mitochondrial mitochondrial accumulation mitochondrial apoptotic pathway mitochondrial translocation molecular non-genomic Non-genomic pathway offered pathway Pathways receptor regulate Regulation remained sensitivity Signaling Support T cell thymocyte Thymocyte apoptosis thymocytes treated Treatment [DOI] 10.1007/s10495-016-1320-8 PMC 바로가기 [Article Type] The Many Ways of Apoptotic Cell Death
How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review세포 사멸 β 세포가 내성 또는 자가 면역 당뇨병에 대한 면역 반응을 지시하는 방법: 리뷰Original Paper Published on 2015-01-222022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] β-Cells Activation antigen presenting cell antigen presenting cells APCS Apoptosis apoptotic cell clearance apoptotic cells apoptotic β-cell autoantigen Autoantigens Autoimmune autoimmune attack autoimmune diabetes Autoimmune disease Autoimmune diseases Autoimmunity Cell contribute contributing to dendritic cells diabetes Effect Efferocytosis endogenous insulin secretion immune response immune tolerance immunological tolerance immunotherapies Immunotherapy increase in induce Inflammation insulin insulin-producing β-cell insulin-producing β-cells long-term tolerance maintenance maturation mechanism medical health challenge metabolic disease pancreatic islet pancreatic islets pancreatic islets of Langerhans Patient physiological mechanism Research self T1D target cell target cells therapy Tolerance tolerance to self translational Treatment Type 1 diabete Type 1 diabetes β-cell β-cells [DOI] 10.1007/s10495-015-1090-8 PMC 바로가기 [Article Type] Original Paper
Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases단핵구 및 대식세포 분화: 염증성 질환에 대한 바이오마커로서의 순환 염증성 단핵구Review Published on 2014-01-072022-08-07 Journal: Biomarker Research [Category] Biochemistry, [키워드] Biomarker broad spectrum cardiovascular diseases changes circulation dendritic cells environmental stimulation express various receptors functional phenotype heterogeneity heterogeneous human disease Indicator Infection inflammatory disease Inflammatory diseases inflammatory monocyte inflammatory monocyte subset inflammatory monocyte subsets inflammatory or anti-inflammatory knowledge Macrophage macrophages MONITOR monocyte monocyte differentiation monocyte heterogeneity Monocytes monocytosis murine potential mechanism rapid progress recruited Research subset suggested tissue tissue damage tissue macrophage tissue macrophages various inflammatory diseases [DOI] 10.1186/2050-7771-2-1 PMC 바로가기 [Article Type] Review
Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice바이오마커 검출 및 임상 실습에서 중요한 도구로서의 면역조직화학Review Published on 2010-02-092022-08-08 Journal: Biomarker Insights [Category] Biochemistry, [키워드] Amino acid amino acids Analysis benefit Cell cell or tissue antigens clinical clinician collaboration complementary detection diagnostic differential diagnose differential diagnoses eosin expression Future hematoxylin Hematoxylin and eosin immunocytochemistry immunohistochemistry immunohistochemistry technique increase in infectious agent infectious agents Interpretation involved knowledge limitations methodology pathologist pathology Patient pooling Practice preparation problem problems prognostic Protein quantification reaction related Research review specific cellular populations Stage stages surgeon technique tissue antigen PMC 바로가기 [Article Type] Review
Novel Biomarkers for the Diagnosis of Urinary Tract Infection—A Systematic Review요로 감염 진단을 위한 새로운 바이오마커 - 체계적인 검토Review Published on 2009-08-052022-08-08 Journal: Biomarker Insights [Category] Biochemistry, [키워드] age asymptomatic bacteriuria Atypical bacteriuria Biomarker Clinical management conducted criteria database diabetics diagnose Diagnosis Diagnostic accuracy Diagnostic Criteria evaluated extreme immunocompromised individuals IMPROVE individual Infection interleukin interleukin 6 kidney transplant recipients methodology morbidity novel novel biomarkers paucity of data pediatric Population Prevalence procalcitonin procalcitonin level pyelonephritis Reporting review searched serum severity shown spinal cord Spinal cord injury STARD subgroup tract Treatment Urinalysis urinary urinary tract infection urinary tract infections urine culture UTI PMC 바로가기 [Article Type] Review
Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer염증 및 암에 대한 지표로서의 인간 키티나제 및 키티나제 유사 단백질Review Published on 2007-05-032022-08-07 Journal: Biomarker Insights [Category] Biochemistry, [키워드] a major Activation AMCase Arthritis Asthma atherosclerotic atherosclerotic plaques Biomarker C-terminal chitin-binding domain Cancer cells cell proliferation chitin chitinase chitinase-like protein chitinase-like proteins chitinases Chitotriosidase chondrocyte chondrocytes circulation cirrhosis contribute cytokine detected diagnostic diagnostic and prognostic marker enzymatic activity enzyme epithelial cells examination family fibrosis found Gaucher Disease glucocorticoid Glucocorticoid treatment Glucocorticoids Glyco_18 Domain Glyco_18 domain-containing protein hepatic fibrosis Human human diseases Human Glyco_18 domain-containing proteins hydrolyse hydrolytic activity IL-4 Indicator Inflammatory bowel disease inherited lysosomal storage involved lipid-laden macrophage lipid-laden macrophages Macrophage macrophage activation macrophages marker mechanism mediators Migration murine murine lectin neutrophil Neutrophils Non-invasive Osteoarthritis overproduced Pathogenesis Patient Prognostic marker progression Protein Proteins regulated rheumatoid arthritis sensitivity Serum level SI-CLP Side effect Side effects solid tumors synovial cells Th2 cytokine Th2 cytokine IL-4 Th2-environment the cell therapy tissue tissues Tumor tumors unique upregulated YKL protein YKL proteins YKL-39 YKL-40 YM1 PMC 바로가기 [Article Type] Review