cascade – Page 19 – Communicable Diseases Research

Hyperthrombotic Milieu in COVID-19 Patients

Review

Published on 2020-10-312022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

Tea Bioactive Modulate Innate Immunity: In Perception to COVID-19 Pandemic

차 생체 활성 조절 타고난 면역: COVID-19 전염병에 대한 인식

Review

Published on 2020-10-282022-08-31
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료제,

[키워드] accumulate activate affected animal model animal models anti-inflammatory properties caffeine Camellia sinensis cascade combating condition copper coronavirus coronavirus disease COVID 19 COVID-19 COVID-19 pandemic Cytokines Disease progression Disruption Drawing effective EGCG ENhance epigallocatechin epigallocatechin gallate experiments gallate green Immunity immunomodulatory impairment In-vitro Infectious disease Infectious diseases Innate innate immune response Innate immunity interferons iron manganese medium Micronutrient micronutrients mitigate modulate natural killer cell Natural killer cells Novel coronavirus novel coronavirus disease nutritional immunity oxygen Pathways Perception pro-inflammatory cytokines processed provide reactive oxygen specy Selenium signaling pathway Soil tea tea polyphenols theaflavin theobromine theophylline trials upregulating Vitamin vitamins water Zinc
[DOI] 10.3389/fimmu.2020.590716 PMC 바로가기 [Article Type] Review

Emerging Molecular Prospective of SARS-CoV-2: Feasible Nanotechnology Based Detection and Inhibition

Microbiology

Published on 2020-10-202022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] affected Antiviral Apoptosis autophagy cascade change changes Community components COVID-19 death demonstrated detection diagnostics dissemination Endoplasmic reticulum Epidemiology Epigenetic event Genetic genetics and epigenetics global pandemic highlight host cell host’s immune response Inflammasome inhibition medications molecular mortality rate nanobased diagnosis nanobased therapeutics Nanotechnology outbreak Probability Prospective SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Scientific community Stress target cells the SARS-CoV-2 therapeutic options unfolded protein response UPR viral infection viral replication viral-induced Worldometer
[DOI] 10.3389/fmicb.2020.02098 PMC 바로가기 [Article Type] Microbiology

Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology

Research

Published on 2020-10-162022-10-28
Journal: BioData Mining [Category] COVID-19,

[키워드] activated Activation Active ingredient ALB albumin Analysis Anti-inflammatory AutoDock B cell binding activity biological process BPS cascade CASP3 cellular response Chinese component Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytoscape Cytoscape software database demonstrated disease docking score Effect effective Effector mechanism Effects EGFR endothelial enrichment analysis epidermal ESR1 estrogen receptor Examining explain Extracellular GAPDH GeneCard Genes growth factor IL-2 Inflammation ingredient injection International JUN KEGG Kyoto less MAPK MAPK1 MAPK14 MAPK8 mechanism Mild molecular docking Necrosis network pharmacology NF-κB nuclear Ontology participated Pathways pharmacological mechanism PI3K potential mechanism potential therapeutic target PPI predict produced Protein protein-protein interaction provided PTGS2 RAS receptor regulated Regulation renin-angiotensin system Result searched Sepsis severe pneumonia signaling pathway STAT3 SwissTargetPrediction database synergistic T-cell receptor target targets therapeutic effect TLR TNF Toll-like receptor Topology Transcription Treatment TRP VEGF was used Xuebijing
[DOI] 10.1186/s13040-020-00227-6 PMC 바로가기 [Article Type] Research

Characterization of community‐wide transmission of SARS‐CoV‐2 in congregate living settings and local public health‐coordinated response during the initial phase of the COVID‐19 pandemic

COVID-19 팬데믹 초기 단계에서 집단 생활 환경 및 지역 공중 보건 조정 대응에서 SARS-CoV-2의 지역 사회 전체 전파 특성

Original Article

Published on 2020-10-152022-09-10
Journal: Influenza and Other Respiratory Viruses [Category] MERS, SARS, 치료기술, 치료제,

[키워드] affecting amplify Analysis attack attack rates board Board of Health Care cascade case finding characterization clinical Cluster Clusters collected Community community transmission congregate living connection containment measures containment strategies COVID‐19 COVID‐19 Critical develop effective effective response effort Engagement Government Health personnel healthcare worker help highest index case initial Intervention Local local health department Nursing Ohio pandemic Population public health residential facilities resources Result SARS‐CoV‐2 severe acute respiratory syndrome coronavirus 2 Support target Transmission Treatment Vulnerable populations
[DOI] 10.1111/irv.12819 PMC 바로가기 [Article Type] Original Article

An aberrant STAT pathway is central to COVID-19

Reviews

Published on 2020-10-092022-10-05
Journal: Cell Death and Differentiation [Category] SARS, 치료제,

[키워드] activate Activation affected age approved drugs ARDS Autopsy bind cardiovascular diseases cascade catastrophic caused characterized chemokines clinical development Clinical symptoms Coagulopathy component COVID-19 DAD diabetes Diffuse alveolar damage drug dysfunction EGFR Endothelial cell ENhance function Hyperactivation hypertension hypoxic environment IFN-I induce Infection inhibit initiated innate immune cell interferon lung Lung injury macrophages nsp1 obesity ORF6 pathophysiology pathway Perspective Phosphorylation positive feedback loop Proinflammatory cytokine Proteins recruitment risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells secretion Severe case Signaling STAT Stat1 STAT3 stimulate subsequent TLR4 Transcription treat Treatment Type upregulation widespread
[DOI] 10.1038/s41418-020-00633-7 [Article Type] Reviews

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

SARS-CoV-2 및 ACE2 증강으로 유발된 염증은 심각한 COVID-19의 다발성 장기 부전을 유발합니다: 분자 메커니즘 및 의미

Review

Published on 2020-10-082022-09-10
Journal: Inflammation [Category] MERS, 바이오마커,

[키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggravate Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bind cascade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokine storm Cytokines develop downregulation drive Evidence failure functional high mortality host cell host cells Inflammation Inflammatory responses Injury interleukin interleukin-6 lead Lung injury Macrophage macrophages massive mechanism monocyte Monocytes Multiple multiple organ dysfunction multiple organ dysfunction/failure multiple organ failure Necrosis NFκB nuclear Occurrence organ dysfunction organs pandemic pathological change pathological changes patients of COVID-19 receptor released Renin renin-angiotensin system replicate respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe patients Severe patients of COVID-19 Spike protein syndrome TNFα Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha widespread
[DOI] 10.1007/s10753-020-01337-3 PMC 바로가기 [Article Type] Review

Application of methylene blue -vitamin C –N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial

Research article

Published on 2020-10-012022-10-05
Journal: European journal of pharmacology [Category] 임상, 치료법,

[키워드] Activation acute respiratory syndrome Administered application approved cascade catastrophic cause clinical trial complications contribute coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Critical Critically ill cysteine cytokine drug FDA FIVE healthy individuals hypoxia ICU induce Inflammatory inflammatory state Interrupting kill Macrophage macrophage activation mechanism metabolite Methylene blue microbial N-acetyl cysteine Nitrate nitric oxide other diseases oxidative stress Pathogenesis Patient patients phenotype pro-inflammatory protocol significantly increased Stress survival rate the disease the patient therapeutic effect therapeutic option Treatment vicious cycle Vitamin C were measured
[DOI] 10.1016/j.ejphar.2020.173494 [Article Type] Research article

Identifying pathophysiological bases of disease in COVID-19

Review

Published on 2020-09-222022-10-29
Journal: Translational Medicine Communications [Category] COVID-19,

Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System

Cell and Developmental Biology

Published on 2020-09-162022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] ACE ACE2 activate addition Ang II Ang-(1-7) angiotensin Angiotensin II anti-inflammatory effect AT1 AT1 receptor binding carried cascade cell entry cellular receptor cleavage cleave clinical trial components consequence convert Coronaviridae family coronavirus Course COVID-19 database domain downregulation effort enzyme facilitate human cells insight Interaction Intervention intracellular signaling involved LILACS Lung injury mechanism membrane fusion membrane-bound molecular interaction pandemic pathogen Pathogenesis pathogenesis of COVID-19 pathway Pathways Perspective pro-inflammatory promote RAS RBD receptor Renin renin angiotensin system Research S2 domain SARS-CoV-2 SARS-CoV-2 cell SciELO Scientific community Signaling spike glycoprotein subunits System therapeutic target TMPRSS2 transmembrane treating COVID-19 Treatment vasoconstriction virus
[DOI] 10.3389/fcell.2020.559841 PMC 바로가기 [Article Type] Cell and Developmental Biology