Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2SARS-CoV-2에 감염된 K18-hACE2 마우스에 대한 멜라토닌 및 멜라토닌성 약물의 치료 가능성Article Published on 2022-01-012022-09-11 Journal: Journal of pineal research [Category] SARS, 변종, 신약개발, [키워드] administration agomelatine benefit candidate changes in Clinical outcome clinical trials Compound COVID-19 COVID-19 pandemic COVID-19 pathogenesis Cytokines Daily disease dose drug Drug repurposing drug treatment drug treatments drugs effective exacerbated expressing hACE2 human ACE2 receptor humans infected with SARS-CoV-2 Infection Inflammatory cytokine Inflammatory cytokines interferons K18-hACE2 K18-hACE2 mice limit Local lung melatonin mice Occurrence preclinical study Prophylactic ramelteon ramelteon. Safe SARS-CoV-2 SARS-COV-2 infection shown Spread survival susceptible Symptom tested therapeutic therapeutic potential treat treated Treatment type I type I and type III interferons type III Type III interferons vaccination variant [DOI] 10.1111/jpi.12772 PMC 바로가기 [Article Type] Article
Identification of raloxifene as a novel α-glucosidase inhibitor using a systematic drug repurposing approach in combination with cross molecular docking-based virtual screening and experimental verificationResearch article Published on 2022-01-012022-10-05 Journal: Carbohydrate Research [Category] 신약개발, [키워드] Alanine amino acid residue analyses approach binding binding affinity binding free energy Combination Contact Critical cross Cross molecular docking database demonstrated diabetes drug Drug repurposing Efficacy FDA identification identify in silico in vitro activity inhibitor interactions molecular Molecular docking study Molecular dynamics simulation molecular dynamics simulations molecular mechanism Mutagenesis performed physiological condition Protein Proteins raloxifene screened stability Toxicity Treatment Virtual screening α-Glucosidase inhibitor [DOI] 10.1016/j.carres.2021.108478 [Article Type] Research article
Evaluating the performance of drug-repurposing technologiesReview article Published on 2022-01-012022-10-05 Journal: Drug discovery today [Category] 신약개발, [키워드] area under the curve Biomedical Informatics comparability comparison Computational drug repositioning Computational drug repurposing Consensus determine drug Drug discovery drug repositioning Drug repurposing Evaluating evaluation metrics lack limitations measure Normalized discounted cumulative gain novel opportunity Patient Performance evaluation Performance metrics platform robust understanding validation [DOI] 10.1016/j.drudis.2021.08.002 [Article Type] Review article
Multi-Targeted Approaches and Drug Repurposing Reveal Possible SARS-CoV-2 InhibitorsArticle Published on 2021-12-262022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] binding affinity caused computational analysis conformational country COVID-19 COVID-19 pandemic death docking drug Drug repurposing DrugBank drugs Effectiveness Escalation experimental validation FDA-approved drug Infection inhibitor inhibitors inhibitory lack memory multi-targeted inhibitors NADH non-structural proteins nutraceutical performed Protein repurposing SARS-CoV-2 SARS-CoV-2 proteins structural proteins Treatment Virtual screening [DOI] 10.3390/vaccines10010024 PMC 바로가기 [Article Type] Article
Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy시험 관내 항 바이러스 활성 및 면역 조절 효과를 갖는 시스 티민은 COVID-19 요법에 대한 용도의 약물 후보가 될 가능성이있다.Article Published on 2021-12-242022-08-31 Journal: Cells [Category] SARS, 신약개발, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory effect Antiviral antiviral action Antiviral effect antiviral effects applied assays Bacteria blood sample Blood samples calu-3 cells candidate caused coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patients COVID-19 therapy CPE cystamine cysteamine Cytopathic effect cytopathic effects decrease demonstrated determine Disulfide drug Drug repurposing Effect IFN-γ immune response immunomodulatory effects in vitro independent independent of investigated modulate Oxidation pandemic parasites Potential repurposing respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly the SARS-CoV-2 therapy for COVID-19 these compound these compounds Treatment Vero E6 VERO E6 cells Viral viruses [DOI] 10.3390/cells11010052 PMC 바로가기 [Article Type] Article
Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approachSARS-CoV-2 감염을 손상/퇴치하기 위한 CK2 매개 신호 표적화: 컴퓨터 생물학 접근Research Article Published on 2021-12-202022-09-10 Journal: Molecular Medicine [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] Analysis antagonist antagonistic effect anticancer antiviral activity antiviral responses approach attenuation bind bleeding Cancer cancer treatment Cell CIGB-300 CK2 inhibitor Coagulation Combination computational analysis Computational biology coronavirus drug Drug repurposing early stage early stages Evidence evidence of Functional enrichment analyses Functional enrichment analysis HSBP1 human cells immune response incidence infected with SARS-CoV-2 inhibitor interfere Interference life cycle mechanism molecular molecular mechanism muscle NPM1/B23 peptide phenotype Phenotypes Phosphoproteomics Phosphorylation predict predicted provide provided recent respiratory respiratory disorders responsible Result RNA splicing SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling SQSTM1 SRSF1 supplementary material Support targeting the SARS-CoV-2 treat Viral viral infection viral infections virus Virus-host interaction Virus-host interactions was used [DOI] 10.1186/s10020-021-00424-x PMC 바로가기 [Article Type] Research Article
Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic StrategiesImmunology Published on 2021-12-202022-10-04 Journal: Frontiers in Immunology [Category] SARS, 신약개발, [키워드] Activation adaptive Analysis anti-inflammatory agent benefit Biomarker cellular ceramide circulating circulation clinical phenotype Clinical studies Cohort Course COVID-19 Critically ill patient demonstrated Drug repurposing evaluate FDA-approved drugs FIASMA functional hallmark healthy controls independent inhibition intensive care intensive care patient lipoprotein membrane molecular biology of critical care molecular markers multicenter observational studies Organ failure pathophysiological pathway provide RBC red blood cell response SARS-COV-2 infection serum severe coronavirus disease severe COVID-19 SMPD1 sphingolipid sphingomyelin sphingomyelinase Strategy Stress subsequent Support the patient treatment strategy Trial with COVID-19 [DOI] 10.3389/fimmu.2021.784989 PMC 바로가기 [Article Type] Immunology
Entrectinib—A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells엔트렉티닙—인간 폐 조직(HLT) 세포의 SARS-CoV-2 억제제Communication Published on 2021-12-182022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 진단, 치료제, [키워드] antiviral assay Antiviral assays antiviral drug antiviral drugs cells COVID-19 COVID-19 outbreak drug candidate drug candidates Drug repurposing entrectinib group Human human cells identify in vitro pharmaceutical companies pseudovirus assay pseudovirus assays Research SARS-CoV-2 Vaccine viral cell entry assays Virtual screening virus vitro pseudovirus assays [DOI] 10.3390/ijms222413592 PMC 바로가기 [Article Type] Communication
Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by AntidepressantsPharmacology Published on 2021-12-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 antidepressant antidepressants Cell complex Concentration COVID-19 diversion Drug repurposing endocytosis endosomal trafficking Endosomes fluvoxamine HEK293T cells highlighting host receptor investigated mechanism membrane Potential Prophylactic protection protective effect provide resulting SARS-CoV-2 severe COVID-19 spike Spike protein the SARS-CoV-2 therapeutic upregulated [DOI] 10.3389/fphar.2021.787261 PMC 바로가기 [Article Type] Pharmacology
Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2SARS-CoV-2에 대한 천연 약물로서의 세파란틴 유사체 평가Research Article Published on 2021-12-092022-09-10 Journal: FEBS Open Bio [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition alkaloid analogue analogues binding affinities binding affinity Cepharanthine Compound conformation coronavirus coronavirus disease Coronavirus disease 2019 database demonstrated DIPHENYL disease docking drug Drug repurposing drugs Efficacy evaluate evaluated Evaluating humans Infection molecular docking molecules natural drug NPC1 performed predicted protease respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV Spike protein suggested target proteins tetrandrine the spike protein these compound these compounds were assessed [DOI] 10.1002/2211-5463.13337 PMC 바로가기 [Article Type] Research Article