human ACE2 – Page 19 – Communicable Diseases Research

Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2

Molecular Biosciences

Published on 2020-12-092022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species

S 단백질을 사용한 인간 ACE2의 in silico 돌연변이 유발 및 번역 효율성은 다른 종의 SARS-CoV-2 감염성을 설명합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Computational Biology [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 variant ACE2 variants addressed affecting affinity allelic Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding cats caused cellular entry coronavirus coronavirus disease coronavirus disease COVID-19 Coronavirus infection COVID-19 pandemic death difference domain early stage Efficiency enzyme explain expression level expression levels Factor Factors feature ferrets Genomic variability hACE2 host protein host proteins Human human ACE2 human angiotensin converting enzyme 2 human cell human cells humans immune response in silico in some in viral individual infect Infection integration Interaction interface mice modify Mutagenesis new virus pandemic PIGS protein-protein interaction proteome RBD domain recognize reported S protein SARS-CoV-2 SARS-CoV-2 virus second sensitivity sequence species Spike protein stability the RBD the SARS-CoV-2 translated translation translational tRNA Variability variant Viral viral infectivity viral mutation Viral protein Viral proteins virus virus isolate waters
[DOI] 10.1371/journal.pcbi.1008450 PMC 바로가기 [Article Type] Research Article

Genetically modified mouse models to help fight COVID-19

COVID-19와 싸우기 위해 유전자 변형된 마우스 모델

Review

Published on 2020-12-012022-09-11
Journal: Nature protocols [Category] 변종, 신약개발, 유전자 메커니즘, 진단, 치료제,

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

RBD-Fc 기반 COVID-19 백신 후보, 매우 강력한 SARS-CoV-2 중화 항체 반응 유도

Article

Published on 2020-11-272022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Antisera binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs domain dominant Economy effective Effective vaccines elicited Epitopes Fc fragment fragment of global health Health human ACE2 IgG immunization Immunopotentiator induce Infection infections live SARS-CoV-2 mice mutants natural mutation natural mutations neutralization neutralize Neutralizing activity neutralizing epitope pandemic Prevent PROTECT pseudotyped pseudotyped SARS-CoV-2 RBD RBD-Fc RBD-specific antibodies RBD-specific antibody receptor Receptor-binding domain respiratory responsible robust Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-related coronavirus SARSr-CoV SARSr-CoVs severe acute respiratory syndrome Coronavirus specific antibodies Spike protein subunit Subunit vaccine the SARS-CoV-2 the spike protein threat transgenic mice Vaccine Vaccines
[DOI] 10.1038/s41392-020-00402-5 PMC 바로가기 [Article Type] Article

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

SARS-CoV-2 감염의 3가지 동물 모델에서 높은 예방 및 치료 효능을 가진 인간 항체의 신속한 식별

530

Published on 2020-11-242022-09-12
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단,

[키워드] Ab1 ACE2 ADCC ADCC activity Administered aggregate aggregation animal model animal models antibody antibody-dependent cellular cytotoxicity Antigen assays BALB/c mice binding Combination competition Complete Coronaviruses COVID-19 Culture dose effective Efficacy elicited exhibited expressing Fab glycoprotein hACE2 hamster hamsters human ACE2 human cell human cell membrane human monoclonal antibodies Human monoclonal antibody IgG1 in vitro inhibited lack lowest mAb mAbs mechanism microbes monoclonal neutralization neutralized pandemic Prophylactic prophylactically Prophylaxis Protein Proteins public health threat Rapid RBD Receptor binding domain replication-competent SARS-CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 replication SARS-CoV-2 spike scFv sequence Significance somatic mutations tested the SARS-CoV-2 therapeutic antibodies therapeutic efficacy therapy tissue tissue culture transgenic mice Vaccines virus virus infection was selected wild-type
[DOI] 10.1073/pnas.2010197117 PMC 바로가기 [Article Type] 530

Impact of SARS-CoV-2 on Male Reproductive Health: A Review of the Literature on Male Reproductive Involvement in COVID-19

Medicine

Published on 2020-11-192022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] ACE2 addition age Analysis angiotensin-converting enzyme 2 caused Cell cells China clinical manifestation Clinical outcome consequence Contact coronavirus 2 COVID-19 death ENhance epidemiological expressed favor Gender Gender differences global pandemic high affinity human ACE2 Impact IMPROVE increase Infection Infectious disease Involvement literature male male fertility male subject mechanism men mortality rate other coronaviruses pandemic pathogen Pathogenesis patients with COVID-19 potential transmission Prevent raise receptor regulated reported reproductive required respiratory Respiratory droplets review SARS-CoV SARS-CoV-2 SARS-COV-2 infection serine protease shown South Korea spermatozoa spermatozoon susceptible The United States These data TMPRSS2 transmitted treat vector virus virus entry with COVID-19 women
[DOI] 10.3389/fmed.2020.594364 PMC 바로가기 [Article Type] Medicine

Sensitization of Non-permissive Laboratory Mice to SARS-CoV-2 with a Replication-Deficient Adenovirus Expressing Human ACE2

인간 ACE2를 발현하는 복제 결핍 아데노바이러스를 사용한 SARS-CoV-2에 대한 비허용 실험용 쥐의 감작

Article

Published on 2020-11-092022-09-11
Journal: STAR protocols [Category] SARS, 치료기술,

Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2

Short Communication

Published on 2020-11-032022-10-04
Journal: International immunopharmacology [Category] SARS, 변종, 진단,

Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment

Research article

Published on 2020-11-012022-10-05
Journal: Journal of molecular graphics & modelling [Category] SARS, 신약개발,

The Pursuit of COVID-19 Biomarkers: Putting the Spotlight on ACE2 and TMPRSS2 Regulatory Sequences

Medicine

Published on 2020-10-302022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] ACE2 added affected binding site Biomarkers conducted contribute coronavirus disease COVID-19 COVID-19 susceptibility discrepancy disease ENhance ethnic group expression expression level expression levels Genetic Genetic variation Host human ACE2 human Angiotensin-converting enzyme implication in silico analysis involved Mortality mortality rate mRNA degradation polymorphism Population populations Prevalence Prognosis protease reduce regulatory sequence regulatory sequence elements sequence serine 2 single-nucleotide SNP SNPs Socioeconomic Factors susceptible target gene target tissues the disease TMPRSS2 Transcription transcription factor transcriptional repressor transmembrane Variation viral infection virus while
[DOI] 10.3389/fmed.2020.582793 PMC 바로가기 [Article Type] Medicine