Intranasal administration of a recombinant RBD vaccine induced protective immunity against SARS-CoV-2 in mouse재조합 RBD 백신의 비강 투여로 마우스에서 SARS-CoV-2에 대한 보호 면역 유도Article Published on 2021-04-152022-09-12 Journal: Vaccine [Category] MERS, 진단, [키워드] Administered administration analyzed antibody Characteristics domain elicited Humoral immunity immune response Immunity immunized indicated injection Intramuscular injection intranasal intranasal administration intranasally mucosal mucosal immunity nasal neutralizing antibody Non-invasive pandemic protective immunity RBD respiratory respiratory viruses Result robust SARS-CoV-2 SARS-CoV-2 vaccine subunit T cell response the vaccine titers of IgG Vaccine [DOI] 10.1016/j.vaccine.2021.03.006 PMC 바로가기 [Article Type] Article
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies전신 중화 항체 치료 후 비갑개에서 강력한 SARS-CoV-2 감염Article Published on 2021-04-142022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome Angiotensin converting enzyme-2 antibody binding characterized competing coronavirus COVID-19 determine DNA hamster human neutralizing antibody implication Infection inhibit SARS-CoV-2 injection Injury intranasal intranasally live SARS-CoV-2 lung lung damage Lung injury nasal nasal turbinate Neutralizing neutralizing antibody phage display RBD Receptor binding Receptor binding domain reduce Reinfection robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly suppresse tested therapy Transmissibility treated Treatment upper respiratory upper respiratory tract vaccination Vaccine viral infection Viral load [DOI] 10.1016/j.chom.2021.02.019 PMC 바로가기 [Article Type] Article
The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model위장관은 비인간 영장류 모델에서 SARS-CoV-2 감염에 대한 대체 경로입니다Article Published on 2021-04-012022-09-11 Journal: Gastroenterology [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caspase 3 caused CD68 Chain Reaction change cleaved Clinical sign Clinical signs connection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines digestive dysfunction evaluated fecal Fecal-Oral Route Gastrointestinal GI Tract goblet cells Histopathology host responses Hypothesis immunohistochemistry increased expression increasingly Infection Inflammation Inflammatory cytokines inoculation intranasal investigated involved Ki67 lung macrophages manifestation Model mucin NHP Pathogenesis pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathologic Patient periodic acid Pneumonia polymerase chain polymerase chain reaction primate quantified Quantitative reported respiratory respiratory tissue respiratory tissues response reverse transcription rhesus Rhesus monkeys route SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe infections staining tissue tissues tract Viral viral genomic RNA viral infection were infected were recorded [DOI] 10.1053/j.gastro.2020.12.001 PMC 바로가기 [Article Type] Article
Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets비강 내 융합 억제 리포펩티드는 흰 족제비에서 SARS-CoV-2 직접 접촉 전파를 방지합니다Report Published on 2021-03-262022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 신약개발, 치료제, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration animal model bind biodistribution C terminus Cell complementary condition conformational change conformational changes conserved Contact Containment coronavirus COVID-19 pandemic Critical Daily dimeric disease effective Efficacy ferret ferrets fusion glycoprotein host cell host cell membrane host cell membranes host cells in vitro in vivo Infection inhibit inhibitor inhibitory initiate initiated intranasal life history lipoprotein Lipoproteins membrane fusion mutant viruses peptide Prevent prevented Prophylactic Prophylaxis reduce reducing respiratory Safe SARS-CoV-2 SARS-CoV-2 transmission Science selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sick Spike protein target tested translate Transmission transmission of SARS-CoV-2 Viral viral spike protein Viral transmission virus [DOI] 10.1126/science.abf4896 PMC 바로가기 [Article Type] Report
Amantadine Inhibits SARS-CoV-2 In VitroAmantadine은 시험관 내에서 SARS-CoV-2를 억제합니다Brief Report Published on 2021-03-242022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] administration airway epithelium amantadine analogy antiviral activity antiviral agent Antiviral agents antiviral drug antiviral drugs approved Concentration COVID-19 demonstrated drug treatment drug treatments Efficacy Evidence Face mask Face masks health emergency Hypothesis in vitro infected with SARS-CoV-2 Influenza influenza A inhalation inhibited intranasal intranasal instillation mandatory Measures pandemic protective vaccine protective vaccines SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication separate experiment severity social distancing tested the SARS-CoV-2 therapeutic Vaccine Vero E6 Vero E6 cell VERO E6 cells [DOI] 10.3390/v13040539 PMC 바로가기 [Article Type] Brief Report
One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infectionMVA 벡터 백신을 1~2회 주사하면 SARS-CoV-2 상부 및 하부 호흡기 감염으로부터 hACE2 형질전환 마우스를 보호할 수 있습니다423 Published on 2021-03-232022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD antibodies antibody Cancer Cell chemokine clinical study Combination coronavirus coronavirus vaccine COVID-19 cytokine Deletion detection Diseases eight Express expressing form full-length S furin hACE2 hACE2 receptor human clinical trials IFNγ immune response immune responses Immunity immunized immunogenic in vitro indicated infected cells Infection infection with SARS-CoV-2 Infectious disease Infectious diseases inhibited injection Intramuscular injection intranasal lethal infection Lower respiratory tract lung Lungs mice modifications modified vaccinia virus modified vaccinia virus Ankara morbidity mRNAs Mutation nasal turbinate nasal turbinates neutralized neutralizing antibody nucleic acids occurred other infectious diseases pandemic passive transfer peptide Prevent prevented proline proline substitutions Protein Proteins provided pseudovirus purified RBD question RBD Receptor binding domain recombinant reduced Replication required respiratory S protein Safe SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein severe acute respiratory syndrome Coronavirus severe disease shown signal peptide Significance single vaccination smallpox vaccine Spread stimulate subgenomic mRNA subgenomic mRNAs subgenomic viral mRNA subgenomic viral mRNAs T cells the S protein the SARS-CoV-2 the signal peptide transfer transgenic mice Transgenic mouse transgenic mouse model transmembrane domain transmembrane domains upper and lower respiratory tracts vaccination Vaccine vaccinia virus Ankara vector vectors Viral virus Virus vector weight loss [DOI] 10.1073/pnas.2026785118 PMC 바로가기 [Article Type] 423
A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaquesShort communication Published on 2021-03-202022-10-05 Journal: Cell Reports Medicine [Category] 비임상, [키워드] ACE2 adenoviral vector Administered chimpanzee adenovirus-vectored vaccine coronavirus disease COVID-19 described disease dose Efficacy expressing human Angiotensin-converting enzyme humans Immunity immunized immunogenicity induce Infection intrabronchial intranasal intranasally limit Lower respiratory tract mice mucosal neutralizing antibody non-human primates pandemic pre-fusion Prevent PROTECT protection Protective Protein receptor required rhesus macaque SARS-CoV-2 SARS-COV-2 infection T cell response Transmission Vaccine [DOI] 10.1016/j.xcrm.2021.100230 [Article Type] Short communication
The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract전임상 억제제 GS441524와 GC376의 조합은 마우스 호흡기에서 SARS-CoV-2의 증식을 효과적으로 억제했습니다Research Article Published on 2021-03-192022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral efficacy blocked caused Clinical studies Combination combined application coronavirus coronavirus disease Coronavirus disease 2019 coronavirus RNA COVID-19 development effective therapy enzyme evaluated global public health GS441524 High-dose inhibited inhibitor intramuscular intranasal low-dose Lower respiratory tract mice mouse model mouse-adapted SARS-CoV-2 nucleotide pandemic pharmacokinetic preclinical inhibitor proliferation protease PROTECT Remdesivir respiratory respiratory tract RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Support synergistic synergistic effect target Treatment [DOI] 10.1080/22221751.2021.1899770 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Rapidly Adapts in Aged BALB/c Mice and Induces Typical PneumoniaPathogenesis and Immunity Published on 2021-03-102022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] acute respiratory syndrome aged BALB/c mouse model alveolar damage antibody Antiviral agents BALB/c BALB/c mice caused clinical manifestation coronavirus coronavirus disease Course COVID-19 Cytokines deep demonstrated disease elicited Evidence feature human infections humans indicated Infection Inflammation inflammatory immune response interferon gamma interstitial pneumonia intranasal isolate Lungs mice morbidity and mortality Mutation neutralized pathogenesis of SARS-CoV-2 pathological change Pneumonia Protein Q498H rapid adaptation RBD reduced replicated Research respiratory tract responses risk factor SARS-CoV-2 SARS-CoV-2 isolate Sequencing significantly susceptibility the RBD the receptor-binding domain the S protein Typical upregulated Vaccine viral burden viral clearance viral replication [DOI] 10.1128/JVI.02477-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs변형된 백시니아 Ankara 벡터 기반 백신은 SARS-CoV-2 감염, 면역 병리 및 폐 기능 장애로부터 원숭이를 보호합니다.Article Published on 2021-03-092022-09-11 Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] abnormality acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach B cell Blood CD8 CD8 T cells Combination coronavirus COVID-19 dysfunction expressing immune induce Infection Inflammation interferon-stimulated genes intranasal lung lung cell lung cells Lungs macaque macaques mice Modified Vaccinia Ankara Neutralizing antibodies neutralizing antibody Neutralizing antibody response pandemic pathology pre-fusion PROTECT protection respiratory rhesus macaques RNA sequencing SARS-CoV-2 SARS-COV-2 infection secreted severe acute respiratory syndrome Coronavirus spike T cell T cell responses T cells the lungs a vaccination Vaccine vaccine candidate vaccinia vector virus replication [DOI] 10.1016/j.immuni.2021.02.001 PMC 바로가기 [Article Type] Article