Conformational variability of loops in the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질 루프의 구조적 가변성Article Published on 2022-03-012022-09-11 Journal: Proteins [Category] SARS, 변종, [키워드] Accuracy Analysis applied binding Characteristics Cluster cluster analysis conformation conformational conformational ensembles conformations COVID-19 decoy selection facilitate flexible identify involved loop loop modeling Protein Protein binding Protein Data Bank protein structure protein structure prediction Region SARS-CoV-2 spike sequence sequence variants. Spike protein structures targets the S protein the SARS-CoV-2 Variability variants viral infection while [DOI] 10.1002/prot.26266 PMC 바로가기 [Article Type] Article
Teaching an old dog new tricks: A lipid membrane-based electric immunosensor for real-time probing of the spike S 1 protein subunit from SARS-CoV-2늙은 개에게 새로운 트릭 가르치기: SARS-CoV-2의 스파이크 S 1 단백질 소단위의 실시간 조사를 위한 지질막 기반 전기 면역 센서Article Published on 2022-03-012022-09-11 Journal: Proteomics [Category] SARS, 치료기술, [키워드] ACE2 Adsorption alteration amplitude Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody changes in core correlated Disease diagnosis early disease extraction followed by human serum in vitro Interaction ionic strength lipid membrane membrane membrane potential membrane potential. monoclonal antibody pathogen Pathogens point-of-care Protein Protein subunit Proteins receptor recorded SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike S1 serum proteins shown spectral analysis Spike protein subunit Teaching the SARS-CoV-2 transmembrane Transmembrane potential [DOI] 10.1002/pmic.202100047 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopesSARS-CoV-2 스파이크는 새로운 에피토프를 노출하는 개방형 삼량체 형태를 가역적으로 샘플링합니다.Article Published on 2022-03-012022-09-11 Journal: Nature Structural & Molecular Biology [Category] SARS, 변종, 진단, [키워드] addition antibody Antibody binding canonical conserved COVID-19 vaccine Cryo-electron microscopy current determined by diagnostics ectodomain electron microscopy epitope Epitopes help hydrogen IMPROVE Kinetics Ligand mass spectrometry modulated natural population Population prefusion prefusion conformation Protein Receptor binding receptor-binding domains SARS-CoV-2 spike sequence temperature the SARS-CoV-2 Therapeutics trimer Vaccines variant [DOI] 10.1038/s41594-022-00735-5 PMC 바로가기 [Article Type] Article
Dual-detection fluorescent immunochromatographic assay for quantitative detection of SARS-CoV-2 spike RBD-ACE2 blocking neutralizing antibodySARS-CoV-2 스파이크 RBD-ACE2 차단 중화 항체의 정량적 검출을 위한 이중 검출 형광 면역크로마토그래피 분석Article Published on 2022-03-012022-09-11 Journal: Biosensors & bioelectronics [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 affinity Algorithm Analysis analyte angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Biomarkers Care Community Comparative analysis convalescent plasma COVID-19 pandemic detect Dual-detection effort ELISA kit fluorescent Immunity immunochromatographic immunochromatographic assay Immunoglobulin immunoglobulins IMPROVE incorporation indicated Lateral lateral flow assay linear Neutralization antibody Neutralizing antibodies neutralizing antibody Point point of care testing positive positive result Precision provide Quantitative Rapid test Ratiometric biosensor RBD RBD-ACE2 Reactions Receptor-binding domain recipients revaccination SARS CoV SARS CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 spike protein sensitivity serum sample Spike protein the RBD the receptor-binding domain the SARS-CoV-2 vaccination Vaccinations Vaccine Viral Viral variants [DOI] 10.1016/j.bios.2021.113883 PMC 바로가기 [Article Type] Article
A reduced graphene oxide-Fe 3 O 4 composite functionalized with cetyltrimethylammonium bromide for efficient adsorption of SARS-CoV-2 spike pseudovirus and human enteric virusesSARS-CoV-2 스파이크 슈도바이러스 및 인간 장내 바이러스의 효율적인 흡착을 위해 세틸트리메틸암모늄 브로마이드로 기능화된 환원그래핀옥사이드-Fe 3 O 4 복합체Article Published on 2022-03-012022-09-11 Journal: Chemosphere [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption cetyltrimethylammonium bromide Combination complex Composite coronavirus CTAB Detection limit electrostatic interaction electrostatic interactions exhibited Fourier-transform infrared spectroscopy Genome HRV Human Human enteric viruses infrared spectroscopy intrinsic pseudovirus public health qPCR analysis reduced Reduced graphene oxide SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike pseudovirus severe acute respiratory syndrome Coronavirus significantly tap transmission electron microscopy Viral transmission virion Virion adsorption. virions virus virus particle virus particles water X-ray diffraction zeta potential [DOI] 10.1016/j.chemosphere.2021.132995 PMC 바로가기 [Article Type] Article
The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implicationsSARS-CoV-2의 스파이크 단백질은 헴 옥시게나제-1을 유도합니다: 병태생리학적 의미Article Published on 2022-03-012022-09-12 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 진단, [키워드] ACE2 Acute kidney injury adaptive AKI angiotensin-converting enzyme 2 assessment caused Cell cell lines cellular clinically COVID-19 COVID-19 patient Effect enzyme examined expression HEK293 heme Heme oxygenase-1 ICAM1 implication induce inducer kidney Kidney injury major organ MCP-1 nephrotoxic outcome overexpressing Plasmid Protective protein expression provide quercetin reduced response SARS-CoV-2 SARS-CoV-2 spike signaling pathway spike Spike protein Spike protein expression Syncytia syncytia formation TNF-α transfected with transfecting upregulate upregulated Urine Vero E6 cell viral spike protein virus was performed [DOI] 10.1016/j.bbadis.2021.166322 PMC 바로가기 [Article Type] Article
Constrictive pericarditis after SARS-CoV-2 vaccination: A case reportSARS-CoV-2 예방접종 후 협착성 심낭염: 증례 보고Case Reports Published on 2022-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Analysis antibody body weight cardiac catheterization cardiovascular complications Case report catheterization caused Computed tomography Constrictive pericarditis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection CT scan Diagnosis Dyspnea echocardiography edema effort heart failure IgM and IgG indicated inspiration Interventricular septum jugular venous pressure mRNA mRNA vaccine nucleocapsid protein Nucleocapsid proteins paradoxical performed peripheral edema Ribonucleic acid SARS-CoV-2 SARS-CoV-2 spike second dose second dose of vaccine septal severe acute respiratory syndrome Coronavirus tomography vaccination Vaccine venous Venous pressure weight gain [DOI] 10.1016/j.ijid.2022.01.027 PMC 바로가기 [Article Type] Case Reports
Design of a population-based longitudinal cohort study of SARS-CoV-2 incidence and prevalence among adults in the San Francisco Bay Area샌프란시스코 베이 지역 성인의 SARS-CoV-2 발병률 및 유병률에 대한 인구 기반 종단 코호트 연구 설계Article Published on 2022-03-012022-09-11 Journal: Annals of epidemiology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] antibody Area Behavior blood sample calculated Characteristics Cohort completion COVID-19 demographics determine determined by enrolled estimate estimates Follow-up General population Health help Households identifying IMPROVE incidence Infection infections Laboratory Laboratory test longitudinal cohort study mail medium nasopharyngeal swabs Neutralizing antibodies non-responders nucleocapsid antigens participant PCR testing population sizes Population-based survey Precision predict Prevalence Probability sample questionnaire Questionnaires random reached recruit recruited Regression model regression models responders risk robust Sample size San Francisco San Francisco Bay SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 viral SARS-CoV-2 viral detection Sociodemographic Sociodemographic characteristics stratified Surveillance unique venous venous blood Viral Viral detection virus [DOI] 10.1016/j.annepidem.2021.11.001 PMC 바로가기 [Article Type] Article
SARS-CoV-2 enzyme-linked immunosorbent assays as proxies for plaque reduction neutralisation testsSARS-COV-2 효소-연결 면역 흡착제 분석 플라크 환원 중화 시험을위한 프록시로서Clinical Trial Published on 2022-03-012022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] antibodies can be used cells coronavirus correlated detect determined by Diagnostic markers diagnostic test diagnostic tests ELISA enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays evaluated generate IgG IgG and IgM IgM immune response immune responses Immunoglobulin immunoglobulins infecting likelihood magnitude MOST NAb NAbs neutralisation test neutralising Neutralising Antibodies neutralising antibody nucleocapsid protein plaque Prevent PRNT Receptor binding domain reduction respiratory Respiratory Coronavirus rising robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike severe acute respiratory coronavirus severe acute respiratory coronavirus 2 Spread subunit titre viral infection virus [DOI] 10.1038/s41598-022-07263-8 PMC 바로가기 [Article Type] Clinical Trial
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants설계된 ACE2 디코이는 SARS-CoV-2 변종으로 인한 폐 손상 및 사망을 완화합니다.Article Published on 2022-03-012022-09-11 Journal: Nature chemical biology [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alpha Amino acid amino acid substitution angiotensin angiotensin-converting enzyme 2 assays B.1.1.7 B.1.351 B.1.617.2 Beta binding affinity coronavirus COVID-19 therapeutics death Delta edema Efficacy feature functional Gamma highlight humanized IgG1 immune responses in vivo injection K18-hACE2 mice lung Lung injury mice mitigate molecular dynamics Molecular dynamics simulation molecular dynamics simulations P.1 P.1 variant prevented Prophylactic Protein S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus soluble ACE2 survival the S protein the SARS-CoV-2 therapeutic therapeutic potential urgency Vaccine hesitancy vaccine-induced immune response vaccine-induced immune responses variants variants of concern Vascular injury VOCs [DOI] 10.1038/s41589-021-00965-6 PMC 바로가기 [Article Type] Article