Reduced Titers of Circulating Anti-SARS-CoV-2 Antibodies and Risk of COVID-19 Infection in Healthcare Workers during the Nine Months after Immunization with the BNT162b2 mRNA VaccineArticle Published on 2022-01-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome administration Analysis anti-S-RBD antibodies antibody Antibody titer Antiviral BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine Cell circulating coronavirus coronavirus disease COVID-19 detectable determinant died dose doses elapsed evaluate evaluated Factor HCW HCWs Health healthcare worker Healthcare workers induce Italy magnitude memory B Month Multivariate analysis pandemic participant pathway Protective antibody protective role provided recipient response Retrospective study robust S-RBD SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection second dose serological severe COVID-19 significantly spike receptor-binding domain study participant T cell response the vaccine titer vaccination Vaccine was performed while worker [DOI] 10.3390/vaccines10020141 PMC 바로가기 [Article Type] Article
Assessing SARS-CoV-2 Neutralizing Antibodies after BNT162b2 Vaccination and Their Correlation with SARS-CoV-2 IgG Anti-S1, Anti-RBD and Anti-S2 Serological TitersArticle Published on 2022-01-152022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Abbott Abbott Laboratories African anti-RBD Anti-S1 anti-S2 Assessing automated Bio-rad BNT162b2 BNT162b2 vaccine Brazil BSL-3 Chicago conditions correlation COVID-19 evaluate gold standard healthcare worker Hercules humoral IgG immune response immunoassays maintain NAb NAbs Neutralizing antibodies neutralizing antibody Panel plaque reduction neutralization PRNT SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 NAb serological serological immunoassays South Spearman’s correlation surrogate virus neutralization test sVNT the SARS-CoV-2 time-consuming titer total antibody USA vaccination variant virus neutralization test Wuhan [DOI] 10.3390/diagnostics12010205 PMC 바로가기 [Article Type] Article
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infectionSARS-COV-2 감염 후 몇 달 후 말초 면역계의 장기 섭동Research Article Published on 2022-01-142022-09-01 Journal: BMC Medicine [Category] SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis anti-RBD Anti-RBD IgG Antibody responses Blood cellular controls convalescent convalescent individual convalescent individuals Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID COVID-19 Critical CXCR3 deep disease severity Effects explain follicular Gene Expression healthy healthy controls IgG responses immune population immune response immune responses immune system Immunity Immunophenotyping in some increasingly individuals Infection Long COVID Mild moderate molecular Monocytes Neutrophils NK cells pandemic PASC Patient persistence Perturbation plethora Post COVID-19 condition Post-acute sequelae of COVID-19 (PASC) Post-infection referred to regulatory T cells reported Research respiratory respiratory virus response responsible Result RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significant differences supplementary material Symptom syndrome T cell T cells T helper transcriptional transcriptional level Transcriptome uninfected [DOI] 10.1186/s12916-021-02228-6 PMC 바로가기 [Article Type] Research Article
Prevalence of antibodies against SARS-CoV-2 among pregnant women in Norway during the period December 2019 through December 20202019년 12월부터 2020년 12월까지 노르웨이 임산부의 SARS-CoV-2에 대한 항체 유병률Short Paper Published on 2022-01-132022-09-11 Journal: Epidemiology and Infection [Category] 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted analysed antenatal care antibodies antibody Antigen Compliance coronavirus detect DiaSorin Elecsy Elecsys Epidemiology estimating explained first trimester hospital IgG immunoassay incidence modelling Norway Occurrence positive test result pregnant pregnant women Prevalence prevalence of disease preventive measure preventive measures remained respiratory Roche Diagnostics S1/S2 S2 protein SARS SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 virus sera serological seropositive serum severe acute respiratory syndrome Coronavirus study period syphilis test results the epidemic the SARS-CoV-2 virus women [DOI] 10.1017/S0950268822000073 PMC 바로가기 [Article Type] Short Paper
SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infectionSARS-COV-2는 무증상으로 가벼운 COVID-19 감염에 대한 내구성 및 항원 특이 적 체액 면역을 유도합니다.Research Article Published on 2022-01-122022-09-10 Journal: PLoS ONE [Category] 진단, 치료기술, 치료법, 치료제, [키워드] anti-Nucleocapsid IgG Anti-spike antibody antibody kinetics Antigen antigens asymptomatic to mild Characteristics COVID-19 COVID-19 infection current detectable discrepant results disease severity exhibited functional generate had no healthcare healthcare worker Healthcare workers hospitalized COVID-19 patient humoral Humoral immunity Humoral response induce longitudinal cohort study magnitude microneutralization Microneutralization assay mild symptoms neutralization capacity nucleocapsid protein participant Participants positive post infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike antigen serological Serological assay serological assays significantly higher Spike protein study inclusion study participant Study participants Support the SARS-CoV-2 the spike protein [DOI] 10.1371/journal.pone.0262169 PMC 바로가기 [Article Type] Research Article
Performance of a flow cytometry-based immunoassay for detection of antibodies binding to SARS-CoV-2 spike proteinArticle Published on 2022-01-122022-10-04 Journal: Scientific Reports [Category] 진단, 치료기술, [키워드] antibodies binding antibody CLIA clinical sensitivity collected convalescent COVID-19 diagnosis of SARS-CoV-2 Elecsy expressing full-length highest IgG immunoassay individual Infection Infectious diseases Infectious-disease diagnostics Microbiology onset of symptom performance positive positive result returned Roche Roche Diagnostics S protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2-specific antibodies sera serological serum/plasma specimen T cell USA Virology [DOI] 10.1038/s41598-021-04565-1 PMC 바로가기 [Article Type] Article
Two Doses of BNT162b2 mRNA Vaccine in Patients after Hematopoietic Stem Cell Transplantation: Humoral Response and Serological Conversion PredictorsArticle Published on 2022-01-102022-10-31 Journal: Cancers [Category] COVID-19, [키워드] addition adverse event adverse events Allogeneic allogeneic transplantation Analysis anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody autologous B-cell BNT162b2 mRNA vaccine CNI collected Concentration conversion correlated COVID-19 COVID-19 pandemic dose Efficacy Efficacy and safety examined HCT Hematological malignancies hematopoietic hematopoietic stem cell transplantation humoral Humoral response immune response predictors immunogenic Immunosuppressive treatment inhibitor intensity knowledge lack lymphocyte subpopulation mRNA mRNA vaccine multivariate model of BNT162b2 Patient patients Post-vaccine predictor predictors remained response SARS-CoV-2 SARS-COV-2 infection searched Seroconversion serological simple STEM Stem cell transplantation Treatment Univariate analysis vaccination [DOI] 10.3390/cancers14020325 PMC 바로가기 [Article Type] Article
Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age rangesCOVID-19 BNT162b2/Comirnaty 백신에 대한 항체 반응에 대한 모집단 균질성은 모든 성인 연령 범위에 걸쳐 2차 접종 후에만 도달됩니다.Article Published on 2022-01-102022-09-12 Journal: Nature Communications [Category] 진단, 치료기술, [키워드] age anti-spike antibody BNT162b2 Care Cohort COVID-19 COVID-19 pandemic dose effort Epidemiology explained heterogeneity heterogeneous homogeneity hospital hospital care humoral immune response Humoral immunity IgA IgG IgM immunogenicity Immunosuppressed increasing age induce Inter-individual variation mRNA vaccine mRNA vaccines nursing home Population population level reached reduced required SARS-CoV-2 spike protein second dose Seroconversion serological Sex single vaccine Spike protein spike-specific IgG the antibody response vaccination Vaccine vaccine dose vaccinees viral infection while [DOI] 10.1038/s41467-021-27761-z PMC 바로가기 [Article Type] Article
Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire질량분석법에 의한 차세대 혈청학: SARS-CoV-2 항체 레퍼토리 판독Article Published on 2022-01-072022-09-11 Journal: Journal of Proteome Research [Category] SARS, 진단, 치료기술, [키워드] antibodies antibody Antibody detection Antigen applied Autoimmune disorders B cells capture captures Clonality clone COVID-19 data type degree heavy chains heterogeneity immune response immune responses Immunity immunized Immunoglobulin individual ion mass spectrometry Ion mass mass spectrometry Metrics Mild molecular pathogen Pathogens plasma Protein proteomics RBD Receptor-binding domain Region repertoire SARS-CoV-2 Sequencing serological serology Spike protein subject the receptor-binding domain the SARS-CoV-2 the spike protein titer top-down mass spectrometry. vaccination vaccine doses variable regions [DOI] 10.1021/acs.jproteome.1c00882 PMC 바로가기 [Article Type] Article
Isolation and Identification of a Rare Spike Gene Double-Deletion SARS-CoV-2 Variant From the Patient With High Cycle Threshold ValueMedicine Published on 2022-01-062022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome amplification Analysis Antiviral antivirals Asymptomatic bioinformatic analysis blind caused Cell Cell culture China close contact Computed tomography coronavirus Coronavirus disease 2019 coughing COVID-19 CT cultured cell cycle Cytopathic effect develop Diagnosis diagnostic disease severity GenBank Genetic variant GISAID Human humans identification immune response indicated Infection isolate Isolation life-threatening Mortality Nasopharyngeal swab nucleic acid amplification Phylogenetic analysis polymerase chain post inoculation presymptomatic pulmonary disease quarantine Region reported Research respiratory droplet RNA genome RT–PCR RT–PCR Sanger sequencing SARS-CoV-2 SARS-CoV-2 virus particle Sequencing serological spike spike gene suggested Swab symptomatic carriers the patient the SARS-CoV-2 virus Transcription Transmissibility two SARS-CoV-2 strain vaccination Vaccines value variant Variation virus virus culture viruses whole genome Wuhan [DOI] 10.3389/fmed.2021.822633 PMC 바로가기 [Article Type] Medicine