Spectrum of neuroimaging findings in COVID-19Pictorial Review Published on 2021-01-012022-10-27 Journal: The British Journal of Radiology [Category] COVID-19, MERS, [키워드] change China Complication COVID-19 Critical Critically ill Encephalopathy feature Hemorrhagic hospitalized COVID-19 hospitalized patient hypertensive hypoxic include infections manifestation multiple sclerosis outbreak positive patient Spectrum spread to state stroke syndrome Venous thrombosis Virus Disease worldwide pandemic [DOI] 10.1259/bjr.20200812 PMC 바로가기 [Article Type] Pictorial Review
First COVID-19 case in Zambia – Comparative phylogenomic analyses of SARS-CoV-2 detected in African countries잠비아 최초의 COVID-19 사례 - 아프리카 국가에서 발견된 SARS-CoV-2의 비교 계통 분석Case Reports Published on 2021-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] activity African Analysis applied B.1 B.1.1 lineage caused China Community Comparative Contact tracing country COVID-19 COVID-19 case Diagnosis Disease surveillance Epidemic epidemic disease Europe Evolution of SARS-CoV-2 France genome sequence Health care Health care worker health care workers incidence of COVID-19 individual initial Lineage lineage B.1.1 MONITOR National Novel coronavirus novel coronavirus SARS-CoV-2 phylogenetic analyses predominant preparation resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 strains South Africa Spread spread to Surveillance sustained the patient Travel while Wuhan Wuhan, China Zambia [DOI] 10.1016/j.ijid.2020.09.1480 PMC 바로가기 [Article Type] Case Reports
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample sizeCOVID-19 치료에서 토실리주맙과 파비피라비르 병용: 소규모 표본 크기의 다기관 시험Randomized Controlled Trial Published on 2021-01-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 임상, 진단, 치료법, 치료제, [키워드] 95 % CI Absorption addition assigned Blood routine clinical symptom Clinical symptoms Combination Combined therapy COVID-19 COVID-19 patient COVID-19 patients cumulative Deterioration drug Efficacy and safety elevated Favipiravir help IL-6 IMPROVE indicated inhibit interleukin interleukin-6 lung Lung CT Lung inflammation lung lesion Multicenter trial no significant difference Patient patients with COVID-19 Primary outcome pulmonary inflammation Randomly reported SARS-CoV-2 Serious Adverse Event Serious Adverse Events significant difference significantly significantly higher small sample size spread to the disease theory Tocilizumab Treatment treatment of COVID-19 with COVID-19 [DOI] 10.1016/j.biopha.2020.110825 PMC 바로가기 [Article Type] Randomized Controlled Trial
Knowledge, Beliefs/Attitudes, and Practices of Rural Residents in the Prevention and Control of COVID-19: An Online Questionnaire SurveyArticles Published on 2020-12-272022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS, [키워드] average collected Complete Control country COVID-19 effective drug ENhance Health individual Infectious disease information international public health knowledge lack outbreak platform Practice prevention Protective questionnaire Region resident risk Self-isolation spread to Support survey susceptible the epidemic the WHO transmission route Vaccines virus was used WeChat [DOI] 10.4269/ajtmh.20-0314 PMC 바로가기 [Article Type] Articles
Do Animals Play a Role in the Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)? A CommentaryCommentary Published on 2020-12-242022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] acute respiratory syndrome addition affecting animal Asymptomatic carrier cause circulating Contagion Contamination coronavirus coronavirus disease Coronavirus-2 coughing CoV COVID-19 COVID-19 patient Denmark determine differential diagnosis discharge disease severity effective environmental health epidemiological Epidemiology epitope Evidence facilitate fecal ferret highlight homologous Human humans immunological IMPROVE infect infected with COVID-19 Infection Infection transmission information Interaction knowledge management measure moderate Neutralizing antibodies occur one health outcome pandemic people with COVID-19 positive progressed public health RaTG13 recognize recommendation related viruses reported respiratory responsible risk role SARS-CoV-2 SARS-COV-2 infection SARS-like coronaviruses sensitivity simple Spread spread to strain susceptible symptomatic tested the disease Transmission variant variants virulence virus viruses were infected wild animals Wuhan, China zoonosis zoonotic [DOI] 10.3390/ani11010016 PMC 바로가기 [Article Type] Commentary
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertensionArticle Published on 2020-12-222022-10-04 Journal: Cell Discovery [Category] 바이오마커, 변종, 신약개발, 임상, 치료제, [키워드] acute respiratory syndrome administration angiotensin-converting enzyme inhibitor anti-SARS-CoV-2 antihypertensive drugs antiviral drug blocker blockers calcium channel caused CCBs Cell Biology Chloroquine clinical investigation clinics Comorbidity coronavirus coronavirus disease country COVID-19 COVID-19 patient COVID-19 patients effective Efficacy elevated event Fatality rate global public health hospitalized COVID-19 patient hypertension IMPROVE in vitro inhibited Mechanisms of disease Mortality outcome receptor reduced Replication retrospective SARS-CoV-2 Severe infection significantly spread to the disease therapy treat [DOI] 10.1038/s41421-020-00235-0 PMC 바로가기 [Article Type] Article
SARS CoV-2 Organotropism Associated Pathogenic Relationship of Gut-Brain Axis and IllnessMolecular Biosciences Published on 2020-12-222022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] abdomen ACE2 receptor Acute cardiac injury Acute kidney injury acute respiratory distress axis Characteristics chest pain China clinical manifestation coronavirus country CoV COVID-19 COVID-19 infection COVID-19 virus Cytokine storm death diarrhea disorder Dysbiosis emesis evaluate Exanthema extra-pulmonary organ fatigue Fever gastrointestinal tract Gut-brain axis hemoptysis illness infected with COVID-19 Infection Interaction involved laboratory-confirmed loss of appetite mechanism MERS microbiota Middle East myalgia nausea nervous system neurological occur outbreak Pain pandemic Patient Pneumonia potential mechanism Prophylactic relationship reported respiratory respiratory tract responsible rhinorrhea SARS CoV-2 SARS-CoV-2 severe cases Shock shown sore throat spread to stroke Symptom syndrome Treatment strategies virus WHO [DOI] 10.3389/fmolb.2020.606779 PMC 바로가기 [Article Type] Molecular Biosciences
Early Psychiatric Impact of COVID-19 Pandemic on the General Population and Healthcare Workers in Italy: A Preliminary StudyPsychiatry Published on 2020-12-222022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] affected age Anxiety asked Complete Contact country COVID-19 COVID-19 pandemic COVID-19 patients DASS-21 Depression develop distress Gender General population healthcare healthcare worker Healthcare workers IES-R Impact index intrusion inventory Italian Italy lombardy outbreak pandemic participant Patient Pittsburgh Population predicted Prevalence Psychiatric psychological support PTSD Quality Responder risk SARS-CoV-2 Sleep spread to Stress Symptom with COVID-19 women worker [DOI] 10.3389/fpsyt.2020.561345 PMC 바로가기 [Article Type] Psychiatry
Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2Pharmacology Published on 2020-12-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] (+)-catechin 4 293T cells ACE2 ACE2 mRNA addition adverse effects Caco-2 cell candidate Compound coronavirus disease cytotoxicity decrease expression Glycyrrhiza uralensis HepG2 cells in vitro in vivo inhibit inhibiting investigated kidney tissue lung occurred Potential Prophylaxis protein expression SARS-CoV-2 SARS-COV-2 infection Simultaneous spread to Taiwan Temple theaflavin theaflavin 3-gallate Tian TMPRSS TMPRSS2 TMPRSS2 expression TMPRSS2 expression level TMPRSS2 protein Treatment Wuhan [DOI] 10.3389/fphar.2020.584158 PMC 바로가기 [Article Type] Pharmacology
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates2개의 RNA 기반 Covid-19 백신 후보의 안전성 및 면역원성Clinical Trial Published on 2020-12-172022-09-12 Journal: The New England Journal of Medicine [Category] MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome added Adults age assigned BNT162b1 BNT162b2 candidate conducted convalescent serum coronavirus coronavirus disease defined disease dose dose-dependent dose-escalation doses Efficacy elicited ENCODE full-length geometric mean titer geometric mean titers Germany group healthy immunogenicity immunogenicity data incidence Infection Interim Local Multiple nucleoside-modified RNA observer-blinded of BNT162b2 Older participant Participants phase 1 trial Placebo placebo-controlled prefusion conformation Primary outcome randomization Randomly receive reported resulting Safety SARS-CoV-2 secondary outcome secreted severity spread to Support systemic reaction The United States the vaccine Trial Vaccine vaccine candidate vaccine dose [DOI] 10.1056/NEJMoa2027906 PMC 바로가기 [Article Type] Clinical Trial