Medicine and Health Sciences – Page 2 – Communicable Diseases Research

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다

Research Article

Published on 2021-01-192022-08-13
Journal: PLoS Pathogens
[Category] COVID-19, Medicine and Health Sciences,

Antibody response to SARS-CoV-2 infection in humans: A systematic review

인간의 SARS-CoV-2 감염에 대한 항체 반응: 체계적인 검토

Research Article

Published on 2020-12-312022-08-13
Journal: PLoS ONE
[Category] Medicine and Health Sciences, MERS, SARS, 진단, 치료기술,

[키워드] Abstract acute phase acute respiratory syndrome antibody Antibody Response Antibody responses appraisal article assessment Asymptomatic asymptomatic infection carried characterising Characteristics clinically cohort study Comprehensive Consensus convalescent plasma Coronaviridae COVID-19 declining demographic characteristics described detectable determinant disease disease control disease onset disease severity eight evaluated Evidence evidenced finding FIVE heterogeneity hospitalised patient Hospitalised patients humoral immune response IgG IgM Immunity implication in vivo initial less limitation literature methodological limitations Mild MOST Neutralising Antibodies neutralising antibody neutralising antibody titre outcome pathogen peaked peaking post-symptom onset Progress protective immunity Public Quality reported researchers respiratory Result SARS-CoV-2 SARS-COV-2 infection screened Serological assay Seven Severe acute respiratory syndrome Specific statistical analysis Study participants symptom onset synthesised systematic review the antibody response the patient Therapeutics title titre titres Vaccines
[DOI] 10.1371/journal.pone.0244126 PMC 바로가기 [Article Type] Research Article

Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China

코로나19 백신 수요와 망설임 이해: 중국 전국 온라인 설문조사

Research Article

Published on 2020-12-172022-08-13
Journal: PLoS Neglected Tropical Diseases
[Category] COVID-19, Medicine and Health Sciences,

[키워드] 95% CI acceptance adverse event benefit China Complete conducted confidence coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cross-sectional decrease Efficacy ENhance expressed Factors followed by Guidance HBM Health health belief Health Belief Model Health promotion Hesitancy highest IMPROVE income indicate Intention interquartile range Intervention investigated IQR majority median Perceived Perceived benefits Perception predictor preference produced proportion receive reduce reported response Result the vaccine understanding utility vaccinate vaccination vaccination intention Vaccine was determined was used
[DOI] 10.1371/journal.pntd.0008961 PMC 바로가기 [Article Type] Research Article

Practical considerations for measuring the effective reproductive number, R t

유효 생식 수, R t 측정을 위한 실제 고려 사항

Perspective

Published on 2020-12-102022-08-13
Journal: PLoS Computational Biology
[Category] Medicine and Health Sciences, MERS, SARS, 치료기술,

[키워드] analysis approach approach assumption Author available data best can be used caution changes in contributed coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical different time point different time points disease transmission distribution effective Effectiveness Epidemic estimate estimation example growth highlight implication individual Infection infections Interpretation Intervention less mitigate moment new infections observation observations open problems pandemic parameter Policy problem public health real time recommendations reconstruction reproductive resulting retrospective Spread the timing Transmission
[DOI] 10.1371/journal.pcbi.1008409 PMC 바로가기 [Article Type] Perspective

False-negative results of initial RT-PCR assays for COVID-19: A systematic review

COVID-19에 대한 초기 RT-PCR 분석의 위음성 결과: 체계적인 검토

Research Article

Published on 2020-12-102022-08-13
Journal: PLoS ONE
[Category] Medicine and Health Sciences, MERS, SARS, 진단,

[키워드] access acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected applicability approach assessment calculated certainty certainty of evidence Chain Reaction collected collected data confirmed cases coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient database defined Diagnostic accuracy eligibility criteria EPPI-Centre Evidence false false-negative False-negative result heterogeneity implication Infection information initial Isolation LILACS logistic regression model management Open Access OSF Patient polymerase chain reaction positive result proportion QUADAS-2 Quality repeated respiratory Result Reverse transcription-polymerase chain reaction risk of bia Risk of bias risk of transmission risks of bia RT-PCR RT-PCR assay SARS-CoV-2 SARS-COV-2 infection screened searched selected several limitations severe acute respiratory syndrome Coronavirus subsequent suspicion systematic review test results
[DOI] 10.1371/journal.pone.0242958 PMC 바로가기 [Article Type] Research Article

Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients

COVID-19로 인해 입원한 환자의 사망 및 중증 질환의 유병률 및 예측인자: 77건의 연구 및 38,000명의 환자에 대한 포괄적인 체계적 검토 및 메타 분석

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS ONE
[Category] COVID-19, Medicine and Health Sciences, MERS, SARS,

[키워드] 95% CI adjusted adverse outcome adverse outcomes analyzed association China Chronic kidney disease chronic liver disease CKD CLD Comorbidities confidence interval COPD COVID-19 COVID-19 patient death determine diabete diabetes died disease Disease progression Europe fatality Health health screening heart disease heterogeneity Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients hypertension Inclusion inclusion criteria individual Infection Kidney disease male males Meta-analysis morbidity morbidity and mortality objective observational studies observational study Patient patients hospitalized predictor Prevalence Public reduce Relative risk Result risk risk factor Risk factors searched severe disease smoking susceptibility susceptibility to infection systematic review Web of Science
[DOI] 10.1371/journal.pone.0243191 PMC 바로가기 [Article Type] Research Article

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

SARS-CoV-2 뉴클레오캡시드 인단백질에 의한 RNA 인식의 구조적 기초

Research Article

Published on 2020-12-022022-08-13
Journal: PLoS Pathogens
[Category] Medicine and Health Sciences, MERS, SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral strategy arginine atomic atomic models Author bind binding binding site C-terminal causative agent characterized complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease dimeric domain double-stranded RNA ENCODE envelope full length Genome Interaction intrinsically involved Like lysines membrane N protein N proteins N-terminal N-terminal domain new SARS-CoV-2 NMR NMR spectroscopy nonstructural proteins nucleocapsid other coronaviruses pandemic Proteins provided respiratory ribonucleoprotein RNA RNA genome RNA virus SARS-CoV-2 SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-stranded single-stranded positive-sense spike structural protein structural proteins subsequent supported the N protein the SARS-CoV-2 the SARS-CoV-2 virus Viral viral genome viral membrane virion virion assembly
[DOI] 10.1371/journal.ppat.1009100 PMC 바로가기 [Article Type] Research Article

Stability of SARS-CoV-2 phylogenies

SARS-CoV-2 계통발생의 안정성

Research Article

Published on 2020-11-182022-08-13
Journal: PLoS Genetics
[Category] COVID-19, Medicine and Health Sciences, SARS,

[키워드] Affect building clade collected Community comparison Comparisons develop discourse effort Evolutionary inference evolutionary inferences evolutionary relationship evolutionary relationships excess facilitate feature genome sequence Genome sequences groups Host host viral genome editing identified variant Inclusion lab local lineage tracing molecular molecular and bioinformatic techniques mutations natural selection phylogenetic inference phylogenies Phylogeny primer binding site primer binding sites problematic variant problematic variants processing produced protein-coding sequence protein-coding sequences provided real-time genetic tracing Recombination recurrent mutation reported SARS-CoV-2 evolution SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 pandemic SARS-CoV-2 phylogenies SARS-CoV-2 phylogeny Scientific community screened sequence Sequencing sequencing error stable clade structure systematic errors the SARS-CoV-2 These data toolkit variant variants variety Viral viral genome viral lineages viral recombination viral sample viral samples Visualization
[DOI] 10.1371/journal.pgen.1009175 PMC 바로가기 [Article Type] Research Article

Superspreading events in the transmission dynamics of SARS-CoV-2: Opportunities for interventions and control

SARS-CoV-2의 전파 역학에서 슈퍼전파 사건: 개입 및 통제의 기회

Essay

Published on 2020-11-122022-08-13
Journal: PLoS Biology
[Category] COVID-19, Medicine and Health Sciences, SARS,

[키워드] acute respiratory syndrome coronavirus basic reproduction number can not Care coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic cruise ships disease empirical evidence Essay etiological agent event Evidence feature globe individuals infecting Influenza influenza) Intervention killing less long tail Long-term care occurred onward transmission opportunity outbreak pandemic Pathogens plants Prevalence recommendation respiratory SARS-CoV-2 Secondary infection secondary infections Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread superspreading event superspreading events targeted intervention targeted interventions Transmissibility Transmission Transmission dynamics virus
[DOI] 10.1371/journal.pbio.3000897 PMC 바로가기 [Article Type] Essay

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

COVID-19에 대한 질병 징후 및 약물 용도 변경에 대한 조사 및 인구 기반 검증에 대한 네트워크 의학 접근 방식

Observational Study

Published on 2020-11-062022-08-13
Journal: PLoS Biology
[Category] Medicine and Health Sciences, 신약개발, 유전자 메커니즘, 임상,

[키워드] 95% CI ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADRB2 African American African Americans age analysis angiotensin Angiotensin II angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors approach approved Asthma asthma patient asthma patients blocker candidate caused Chain Reaction co-expression Comorbidity Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Crohn disease database disease disease manifestation elevated Enterocyte host protein identify ileal increase individual Inflammatory Inflammatory bowel disease IRAK3 Laboratory Laboratory test likelihood Manifestations mechanism Medical conditions melatonin metabolomics methodology molecular morbidity morbidity and mortality network observation observational study Odds ratio pandemic Pathogenesis Patient platform positive positive test result potential treatments Propensity score protein interactions protein–protein interactions proteome proteomics receptor Receptor Blockers reduced respiratory risk SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Sex significantly single-cell Single-cell RNA sequencing smoking test result therapy tissue tissues TMPRSS2 Transcriptome transcriptomics Treatment treatment of COVID-19 widespread with COVID-19
[DOI] 10.1371/journal.pbio.3000970 PMC 바로가기 [Article Type] Observational Study