Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases전신 염증성 질환이 있는 면역 저하 환자에서 알파 및 델타 변이체에 대한 BNT162b2 백신의 면역원성Article Published on 2022-05-012022-09-11 Journal: Annals of the rheumatic diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] abrogated Alpha alpha and delta variants analysed anti-spike antibodies anti-spike antibody anti-Spike IgG B-cell B.1.617.2 BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections Control controls COVID-19 Delta delta variant Delta variants dose effort Endpoint evaluate exhibiting healthcare humoral Humoral response Immune escape immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunogenicity impairing IMPROVE individual infected with SARS-CoV-2 Inflammatory diseases Kinetics methotrexate mounted neutralisation neutralising Neutralising activity of BNT162b2 Other Patient primary endpoints Prospective raise regimen responses rituximab SARS-CoV-2 secondary Secondary endpoints sera Seroconversion Specific T-cell response strain Strains Support systemic inflammatory disease systemic inflammatory diseases T-cell T-cell Response T-cell responses therapeutic treated vaccination Vaccine Viral viral fitness [DOI] 10.1136/annrheumdis-2021-221508 PMC 바로가기 [Article Type] Article
Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain스파이크 수용체 결합 도메인의 특정 에피토프를 표적으로 하는 단일클론항체에 의한 SARS-CoV-2 감염의 중화 또는 증강Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody-dependent enhancement binding binding epitope caused cellular contrary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity Delta demonstrated dose-dependent manner ELISA epitope Epitopes Epsilon exhibited exhibiting experiment Gamma HEK293T cells Infection lentivirus MERS-CoV monoclonal antibodies monoclonal antibody mouse monoclonal antibody NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody Prophylactic Protein pseudotyped RBD receptor Receptor binding domain Receptor-binding domain reduction Region reported residue residues respiratory S protein S proteins SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike Spike receptor binding domain Spike receptor binding domain. spike receptor-binding domain the RBD the receptor-binding domain the S protein Therapeutic treatment variant variants of SARS-CoV-2 wild-type [DOI] 10.1016/j.antiviral.2022.105290 PMC 바로가기 [Article Type] Article
An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages조작된 나노 리포솜 인간 ACE2 미끼는 쥐와 인간 대식세포 모두에서 SARS-CoV-2 스파이크 단백질 유도 염증을 중화합니다Article Published on 2022-03-062022-09-11 Journal: Theranostics [Category] SARS, 유전자 메커니즘, [키워드] abrogate abrogated ACE2 activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding biotinylated canonical CCL-2 chemokines competitive inhibitor complex coronavirus CXCL-10 cytokine D614G deficiency DEGs demonstrated differentially expressed gene Effect enzyme expressing expression fusion generate glycoprotein hACE2 human ACE2 human host cells human macrophage human macrophages IKKβ IKKβ/NF-κB signaling IL-1β IL-6 Immune cell immune cells in vitro in vivo Infection Inflammation Inflammatory response Inflammatory responses inhibit SARS-CoV-2 inhibitor internalization Intravenous injection IκB lentivirus Liposome Liposome-Human ACE2 Macrophage macrophages mechanism mice molecular murine myeloid-specific IKKβ knockout. neutralize NF-κB NF-κB activation NF-κB signaling Protein rationale receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 spike glycoprotein severe acute respiratory syndrome Coronavirus Signaling spike spike glycoprotein Spike protein stimulated Therapeutic approach tissue inflammation TNFα Treatment was used wild type [DOI] 10.7150/thno.66831 PMC 바로가기 [Article Type] Article
Humoral serological response to the BNT162b2 vaccine is abrogated in lymphoma patients within the first 12 months following treatment with anti-CD2O antibodiesBNT162b2 백신에 대한 체액 혈청학적 반응은 항-CD2O 항체 치료 후 첫 12개월 이내에 림프종 환자에서 폐지됩니다.Article Published on 2022-03-012022-09-12 Journal: Haematologica [Category] MERS, SARS, 진단, [키워드] Abbott abrogated administration Analysis anti-CD20 antibody blood sample BNT162b2 vaccine CD20 COVID-19 cross-sectional Cutoff develop dose enrolled Factor generate humoral identify IgG Immunity injection lymphoma monoclonal antibodies monoclonal antibody morbidity and mortality of BNT162b2 Patient patients Pfizer positive response predictors second dose serological response the SARS-CoV-2 therapy treated Treatment vaccination schedule Vaccine vaccine dose were measured while [DOI] 10.3324/haematol.2021.279216 PMC 바로가기 [Article Type] Article
Imaging of innate immunity activation in vivo with a redox-tuned PET reporter Research Published on 2022-02-212022-10-05 Journal: Nature biotechnology [Category] 바이오마커, [키워드] abrogated activated Activation Arthritis bind blocked by product caused Cell cells cellular contact dermatitis effector molecule Enzymes foci H2O2 HL-60 human cell imaging in vivo Inflammatory inhibitor Innate immunity less MPO murine model myeloperoxidase NADPH NOX2 oxidized pet PET/CT phorbol ester PMA Protein reactive nitrogen specy reactive oxygen specy reporter robust Shock signaling molecules tomography [DOI] 10.1038/s41587-021-01169-y [Article Type] Research
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19Research Article Published on 2022-01-102022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] abrogated Anti-inflammatory therapy anti-inflammatory treatment autocrine Bacterial Bacterial infection bacterial superinfection bacterial superinfections caused CD11b CD163 CD66b CD86 Cell cellular characterized classical Clusters complicate Course COVID-19 COVID-19 patient COVID-19 patients Critically ill CRP CXCR1 CXCR2 CXCR4 cytokine cytokine levels cytokine signaling Dexamethasone disease severity driven by dysregulated dysregulation elevated Ex vivo exacerbate exhibited expression function functional HLA-DR host response host-response hypercytokinemia Hyperinflammatory ICU IFN-γ IL-4 IL-6 level Immune cell immune cells immune response IMPROVE increased mortality induce Inflammatory marker inflammatory mediator Inflammatory mediators innate immune function Innate immunity low expression monocyte Monocytes MPO myeloid cell NET neutrophil paracrine paralysis patients phenotype phenotypic plasma provide receiving reduced reduction reduction in reflected response ROS production SARS-CoV-2 SARS-CoV-2 pathogenesis subsequent suppressed surface receptor Symptom synergistic systemic inflammation the disease TNF-α treated utility [DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article
Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2SARS-COV-2에 대한 항 -RBD 인간 단일 클론 항체의 구조 및 치료 가능성Research Paper Published on 2022-01-012022-09-01 Journal: Theranostics [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] In vitro and in vivo function abrogated ACE2 Analysis anti-RBD Anti-RBD antibody anti-receptor-binding domain antibodies antibody antibody cocktail Antibody-antigen complex attenuate B.1.1.7 B.1.351 B.1.617.2 binding cocktail convalescent patient Convalescent patients COVID-19 Cryo-electron microscopy Crystallography curtail dissect effective Efficacy electron microscopy epitope Epitopes evaluate feature Formulation hamster hamsters Hospitalization Human monoclonal antibody in vitro in vivo Infection leads lung viral load mechanism mechanism of action monoclonal antibodies monoclonal antibody Mutation neutralization Neutralizing neutralizing monoclonal antibodies non-overlapping epitope non-overlapping epitopes patients with SARS-CoV-2 Prevent Prophylactic pulmonary inflammation RBD Receptor-binding domain epitope reduce reported residue reveal SARS-CoV-2 SARS-COV-2 infection shown somatic mutations Structural analysis Structure structure-function subsequent Support the RBD therapeutic therapeutic potential unique variable region variant variants variants of concern Viral viral RBD viral shedding virus weight loss wild type [DOI] 10.7150/thno.65563 PMC 바로가기 [Article Type] Research Paper
Adverse Outcome in COVID-19 Is Associated With an Aggravating Hypo-Responsive Platelet PhenotypeCardiovascular Medicine Published on 2021-12-102022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] abrogated Adverse aggravate aggregate aggregation association Complication component Coronavirus disease 2019 COVID-19 COVID-19 patient degranulation disease Disease progression dysregulation healthy donor Hospitalization immune response immunoregulation increase in Infection Inflammation less outcome Patient phenotype plasma Plasma marker Platelet platelet activation platelet activation and reactivity platelet dysfunction platelet-leukocyte interaction reactivity response responses responsible while [DOI] 10.3389/fcvm.2021.795624 PMC 바로가기 [Article Type] Cardiovascular Medicine
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathwayResearch Article Published on 2021-12-062022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] abrogated activate Activation administration CCL2 chemokines co-cultured COVID-19 CXCL1 CXCL2 Cytokine storm elicited epithelial cell expressing S protein Extracellular Hyperinflammatory IFN IL-1β IL-6 induce Inflammation Inflammatory cytokine inflammatory function Inflammatory response investigated lung epithelial cell Macrophage macrophages mechanism membrane mice mouse macrophages NF-κB pathway nucleocapsid pathogenesis of COVID-19 potential therapeutic target produced Protein Proteins S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Spike protein stimulated structural protein the cytokine storm These data TLR1 TLR2 TLR6 TNF-α TNFα Trigger viruses wild-type [DOI] 10.7554/eLife.68563 PMC 바로가기 [Article Type] Research Article
A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infectionArticle Published on 2021-11-302022-10-04 Journal: NPJ Vaccines [Category] 치료기술, [키워드] abrogated addition antibody B.1.1.7 B.1.351 BCG Blood Cell circulating correlated COVID-19 COVID-19 vaccine cytokine release detectable disease effective Experimental models of disease follicular heterologous vaccine Immunity immunostimulatory Inflammation K18-hACE2 mice Local lung Lymph node mice NAbs plasma B cell promoted PROTECT protective immunity Protein vaccines provide regimen responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralising antibody SARS-CoV-2 spike antigen SARS-CoV-2 variant SARS-CoV-2 variants single dose T cells trimeric tuberculosis vaccine vaccination Vaccine virus Virus-specific IgG [DOI] 10.1038/s41541-021-00406-4 PMC 바로가기 [Article Type] Article