Randomized, placebo controlled, double blinded pilot superiority phase 2 trial to evaluate the effect of curcumin in moderate to severe asthmatics중등도 내지 중증 천식에서 커큐민의 효과를 평가하기위한 무작위, 위약 제어, 이중 블라인드 파일럿 우월성 2 단계 시험Study Protocol Published on 2021-08-172022-09-01 Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, SARS, 비임상, 임상, 진단, [키워드] adjunct adopted anorexia Anti-inflammatory anti-inflammatory properties Anti-oxidant approved Arthritis Asthma baseline benefit blinded Blood breath by mouth can be used change clinic visit Clinic visits contribute control test COVID-19 COVID-19 pandemic Curcumin derivative determine Enzymes eosinophil Eosinophil count evaluate the effect finding Follow-up FVC IgE Inflammatory Inflammatory marker inflammatory markers institutional review board Intervention Lung diseases Lung inflammation matching placebo medical condition mice moderate Moderate asthma moderate to severe mouth pathway Patient patients with moderate Phase 2 phase 2 trial Placebo predicted Randomized receiving reducing reduction in screening visit Severe asthma shown Study design study period Study protocol therapeutic effect therapeutic effects therapy treat Treatment Trial registration university USA [DOI] 10.1186/s12890-021-01619-y PMC 바로가기 [Article Type] Study Protocol
Tofacitinib as an Adjunct Immunomodulator for Treatment of a Patient with Severe COVID-19: A Case ReportCase Report Published on 2021-06-302022-10-30 Journal: JNMA: Journal of the Nepal Medical Association [Category] Coronavirus, SARS, [키워드] dexamethasone immunomodulation addition adjunct coronavirus disease COVID-19 Dexamethasone immunomodulator IMPROVE janus Kinase inhibitor outcome Patient patients progressive respiratory failure proportion report Respiratory Support Serum inflammatory biomarkers shown steroid supportive care Tofacitinib use of corticosteroid use of steroids worsening [DOI] 10.31729/jnma.6680 PMC 바로가기 [Article Type] Case Report
Can Resveratrol-Inhaled Formulations Be Considered Potential Adjunct Treatments for COVID-19?레스베라트롤 흡입 제형이 COVID-19에 대한 잠재적인 보조 치료제로 간주될 수 있습니까?Review Published on 2021-05-192022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjunct administration airways Anti-inflammatory Antiviral antiviral activities antiviral activity antiviral drug Asymptomatic Bioavailability Can caused Cell culture Characteristics characterized Clinical practice Compound Concentration coronavirus COVID-19 COVID-19 severity cytokine Cytokine storm disease downregulate effective epithelial epithelial cell evaluated excessive inflammatory response experimental models Formulation global healthcare IMPROVE Infection Inhaled inhaled formulations inhibit SARS-CoV-2 involved leads mechanism Mild molecule monoclonal antibodies oral administration outcomes pandemic Patient pharmacokinetic Pneumonia polyphenol Potential Replication respiratory Respiratory failure respiratory tract illness resveratrol Safe SARS-CoV-2 SARS-CoV-2 replication severe viral pneumonia shown Treatment upper respiratory tract Viral Viral pneumonia viral replication [DOI] 10.3389/fimmu.2021.670955 PMC 바로가기 [Article Type] Review
Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19Medicine Published on 2021-05-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome adjunct Anti-inflammatory approach attenuate cause clinical trial clinical trials Complication coronavirus coronavirus disease Corticosteroids COVID-19 COVID-19 patient Cytokine storm death rate described effective effective drugs effort evaluated excessive inflammation experimental model help immunological Inflammation Inflammatory inflammatory disease inhibitor Intravenous immunoglobulin investigated management modulating nerve nerve stimulation neuromodulation non-drug therapy organ outcome pathophysiology pathway Patient Potential Preliminary data programmed cell death Protein reduce reducing Research SARS-CoV-2 Sepsis the cytokine storm therapeutic therapeutic strategy therapy Tocilizumab Topic Treatment Trial Vagus Vagus nerve stimulation [DOI] 10.3389/fmed.2021.625836 PMC 바로가기 [Article Type] Medicine
Ozone therapy in COVID-19: A narrative reviewCOVID-19의 오존 요법: 내러티브 검토Review Published on 2021-01-022022-09-11 Journal: Virus research [Category] 치료제, [키워드] Acute coronary syndrome acute coronary syndromes adjunct administration alternative Antiviral antiviral activity antiviral drug antiviral drugs applicability article Autohaemotherapy Blood Combination Combined combined treatment COVID-19 COVID-19 treatment cytokine Cytokines database demonstrated Diseases enhancer Evidence gamma interferon hospital identify immune Immunity immunological inactivation Inflammation interferon interferons intravenous Italian lung damage methodology modulation monotherapy oxygen Ozone Ozone therapy Patient patients with COVID-19 Pneumonia protocols pulmonary pulmonary diseases reduction in reperfusion SARS-CoV-2 pneumonia selected Society standard treatment systemic therapeutic therapy Treatment Viral viral replication viruses website were used [DOI] 10.1016/j.virusres.2020.198207 PMC 바로가기 [Article Type] Review
Vitamin D3 as Potential Treatment Adjuncts for COVID-19Review Published on 2020-11-142022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] “cytokine storm” Activation Acute respiratory infection acute respiratory syndrome Adaptive immune response adjunct ARDS cause characterized clinical trial coronavirus COVID-19 Critical distress drug dysregulation effort Health Host immune response IL-1 IL-6 immune activation immunomodulation immunomodulatory Infection Infectious disease inflammatory process Innate immunity mechanism Meta-analysis observational study pandemic Potential prevention promote Protective receptor risk SARS-CoV2 SARS-CoV2 immunopathology SARS-CoV2 infection significant increase supported syndrome systemic hyperinflammation therapy Vaccine VDR viral infection Vitamin D Vitamin D receptor Vitamin D supplementation Vitamin D3 [DOI] 10.3390/nu12113512 PMC 바로가기 [Article Type] Review
Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese PatientsNutrition Published on 2020-10-222022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] acute respiratory syndrome adjunct boost caused China clinical clinical impact clinical trial Comorbidity coronavirus COVID-19 Cytokines disease effective global pandemic Health host immunity Impact Inflammation Intervention management Micronutrient micronutrients nutrient nutrition obese patients Potential reducing SARS-CoV-2 severity of symptom Standard therapy supportive care therapy Treatment viral infections [DOI] 10.3389/fnut.2020.580504 PMC 바로가기 [Article Type] Nutrition
Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19?호흡기 플루오로퀴놀론, 레보플록사신 및 목시플록사신이 COVID-19의 보조 치료제로 유용할 수 있습니까?Article Published on 2020-10-012022-09-11 Journal: Archives of medical research [Category] SARS, 신약개발, 치료제, [키워드] adjunct adjuncts anti-inflammatory drug Anti-inflammatory drugs Antibiotics antimicrobial agents antiretroviral drug Antiviral antiviral action antiviral activity attenuation binding broad spectrum characterized Chloroquine ciprofloxacin CMV community-acquired pneumonia comparable Concentration COVID-19 COVID-19 pandemic Cytokines derivative effective therapy exhibiting Fluoroquinolone HCV HIV HSV-1 immunomodulatory immunomodulatory properties in silico Infection Inflammatory response inhibit SARS-CoV-2 levofloxacin Lungs management moxifloxacin nelfinavir papovavirus pharmacokinetic Pneumonia pro-inflammatory cytokines prodrome protease Protease inhibitor quinoline Replication researcher respiratory respiratory infections safety profile SARS-CoV-2 SARS-CoV-2 replication shown therapeutic agent therapeutic agents treat Treatment vaccinia virus [DOI] 10.1016/j.arcmed.2020.06.004 PMC 바로가기 [Article Type] Article
COVID-19 Airway Management Isolation ChamberCOVID-19 기도 관리 격리 챔버Multicenter Study Published on 2020-07-142022-09-10 Journal: Otolaryngology--Head and Neck Surgery [Category] MERS, SARS, 치료기술, [키워드] adjunct aerosolization airborne airway management appear applicability barrier Care center chamber collected coronavirus COVID-19 determine Efficacy Health Health care Health care worker health care workers IMPROVE limit Measures objective outcomes pandemic Particle Particles Particulate Patient Patient care Personal protective equipment Result Safety measures setting significantly smoke tested time interval time intervals [DOI] 10.1177/0194599820942500 PMC 바로가기 [Article Type] Multicenter Study
Implementation of a modified drive-through sampling strategy for SARS-CoV-2-the Nigerian experienceSARS-CoV-2-나이지리아 경험에 대한 수정된 드라이브 스루 샘플링 전략 구현Research Published on 2020-07-092022-09-01 Journal: The Pan African Medical Journal [Category] MERS, SARS, 진단, [키워드] adjunct average best conducted coronavirus disease COVID-19 dependent on drive drive-through testing effective eligibility eligible Health health workers Internet measure MOST participant PROTECT Quantitative Registered Safe Safety measures sample collection SARS–CoV-2 scientist Spread statistically significant uptake virus walk-in was collected website were recorded while [DOI] 10.11604/pamj.supp.2020.35.2.24319 PMC 바로가기 [Article Type] Research