antagonists – Page 2 – Communicable Diseases Research

Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B 2 receptor antagonism

키닌 B 2 수용체 길항작용에 의한 기관지 상피의 SARS-CoV-2 복제의 조기 감소

Original Article

Published on 2022-03-052022-09-10
Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Up-regulated serum levels of soluble CD25 and soluble CD163 in pediatric patients with SARS-CoV-2

SARS-CoV-2 소아 환자에서 가용성 CD25 및 가용성 CD163의 상향 조절된 혈청 수준

Original Article

Published on 2022-03-022022-09-11
Journal: European journal of pediatrics [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] age antagonist antagonists CD163 children Control COVID-19 cytokine Cytokine storm diagnostic biomarker Diagnostic biomarkers disease severity ELISA healthy control help hemophagocytic lymphohistiocytosis HLH host response Inflammatory initial Level marker MIS-C monitoring outcome Patient patients with COVID-19 patients with SARS-CoV-2 Pediatric patient presenting pro-inflammatory receptor SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients sCD163 sCD25 serum Serum level severity significant decrease significantly higher soluble CD25 syndrome the disease the healthy therapeutic Treatment up-regulated were measured
[DOI] 10.1007/s00431-022-04398-8 PMC 바로가기 [Article Type] Original Article

Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features

COVID-19 치료용 면역조절제: 가능한 작용 기전 및 면역병리학적 특징

Review

Published on 2022-03-012022-09-11
Journal: Molecular and cellular biochemistry [Category] MERS, 진단, 치료기술, 치료제,

[키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme Anosmia antagonists applied ARDS blood vessel body aches cause clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 case COVID-19 patient COVID-19 patients COVID-19 treatment Critical critical patients cytokine Cytokine storm Cytokines demonstrated described drug drugs dry cough Endothelial cell endothelial cells excessive secretion feature Fever Health Organization immune system immunomodulatory immunopathology immunosuppressive agent Immunosuppressive agents incidence include Infection Inflammatory responses interleukin investigated lead Lungs mAbs mechanical ventilator mechanism mechanism of action medication membrane mitigate modulating monoclonal antibodies monoclonal antibody mortality rates new virus Novel coronavirus overproduction oxygen Oxygen therapy pandemic pathophysiology Patient patients penetrate Physicians pro-inflammatory factors receptor reduce mortality researchers respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway signaling pathways stimulate Support Symptom syndrome the disease therapeutic compound treat triggering virus World Health Organization Wuhan Wuhan, China
[DOI] 10.1007/s11010-021-04325-9 PMC 바로가기 [Article Type] Review

Elevated Cytokine Levels in Plasma of Patients with SARS-CoV-2 Do Not Contribute to Pulmonary Microvascular Endothelial Permeability

SARS-CoV-2 환자의 혈장에서 증가된 사이토카인 수준은 폐 미세혈관 내피 투과성에 기여하지 않습니다

Research Article

Published on 2022-02-162022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] accounted ACE-2 receptor ACE2 antibody acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection angiopoietin antagonists antiinflammatory cytokines appear approach ARDS barrier dysfunction C3a C5a cause Cell changes in circulating Combination complement complements factors consecutive patient Control controls coronavirus cytokine Cytokines death demonstrated determine disrupt Effect eight Elevation endothelial Endothelial cell endothelial injury endothelial permeability enrolled evaluated Evidence evidence of Frequency greater growth factor heat inactivation human lung in vitro infections inhibitors labile Level lung magnitude mechanism Microvascular damage morbidity morbidity and mortality multiorgan failure Neutralizing antibodies neutralizing antibody occur patients patients hospitalized patients with SARS-CoV-2 permeability plasma positive control predicted produced proinflammatory cytokines provide pulmonary receptor receptor antagonists respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 plasma selected severe acute respiratory syndrome Coronavirus severe complication severe complications Spike protein subsequent susceptible syndrome the SARS-CoV-2 thrombin TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variability Vascular vascular endothelial growth factor Vascular injury vascular permeability VEGF
[DOI] 10.1128/spectrum.01671-21 PMC 바로가기 [Article Type] Research Article

A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection

새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다

Immunology

Published on 2022-02-162022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] 2019-nCoV 2019-nCoV/USA-WA1/2020 ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration amplify Analysis androgen Androgen receptor angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animal animals antagonist antagonists bind caused CD4 Cell clinical development Clinical studies clinical study coronavirus COVID-19 Critical days post-infection decrease Defense domain dose-dependent DPI Efficacy enzyme examined expression glucocorticoid Glucocorticoid receptor golden hamster hamster Host host defense humans IL-6 indicated infiltration Inflammation inflammatory lung injury Inflammatory response Innate innate immune Innate immunity intranasally lack lung Lung histopathology Lung injury lung tissue Macrophage macrophages mechanism mechanism of action Model modulator molecular docking studies Molecular docking study novel oral administration outcome patients Phylogenetic analysis positive Predictive Prevent progression protease Protein PT150 receptor receptors reduce regulated Replication replication of SARS-CoV-2 required Research respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 severe acute respiratory syndrome Coronavirus shown strain surface protein T-cell T-cells TCID the cell therapeutic therapeutic efficacy Therapeutics tissue damage tissue injury TMPRSS2 transcriptional repressor transcriptionally transmembrane Treatment USA-WA1/2020 variants variants of SARS-CoV-2 Viral viral entry Viral load virus were infected
[DOI] 10.3389/fimmu.2022.811430 PMC 바로가기 [Article Type] Immunology

Montelukast Inhibits Platelet Activation Induced by Plasma From COVID-19 Patients

Pharmacology

Published on 2022-02-082022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory distress addition Affect aggregates antagonists anti-inflammatory properties arachidonic acid Asthma auxiliary Bronchoalveolar lavage cardiovascular diseases characteristic characterized circulating COVID-19 COVID-19 patient COVID-19 patients disease Efficacy elevated endothelial cell damage expression feature implicated induced Inflammation inhibit inhibiting involved leukotriene leukotriene antagonists leukotrienes lipid mediator LTC metabolism Microvesicles Montelukast P-selectin plasma platelet activation pro-inflammatory protective role receptor reducing resulting severe COVID-19 patient suggested syndrome thrombotic tissue Tissue Factor treatment for COVID-19 widespread
[DOI] 10.3389/fphar.2022.784214 PMC 바로가기 [Article Type] Pharmacology

Chronic Lymphocytic Leukemia in the SARS-CoV-2 Pandemic

SARS-CoV-2 유행병의 만성 림프구성 백혈병

Review

Published on 2022-02-012022-09-12
Journal: Current oncology reports [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] antagonists anti-CD20 anti-SARS-CoV-2 anti-SARS-CoV-2 immune responses antibody BTK BTK inhibitors cancers Case fatality rate caused CFR CFRs chronic chronic lymphocytic leukemia Clinical course CLL CLL patient CLL patients Comorbidity contribute controls COVID-19 COVID-19 incidence COVID-19 vaccine decrease deficiency Efficacy elevated form General population greater healthy Hospitalization immune immune response immune system Immunosuppression IMPROVE incidence Infection leukemia lymphoproliferative disease malignancies malignancy monoclonal antibodies older patients outbreak outcome Oxygen therapy pandemic Patient patients with comorbidity Prevalence recent reduced reported response risk of death SARS-CoV-2 SARS-CoV-2 positivity severe infections significantly significantly higher Spike-specific antibody the disease the median the SARS-CoV-2 therapy Treatment vaccination Vaccine Vaccines
[DOI] 10.1007/s11912-022-01198-z PMC 바로가기 [Article Type] Review

Pulmonary artery targeted therapy in treatment of COVID-19 related ARDS. Literature review

Review article

Published on 2022-02-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 치료법, 치료제,

[키워드] acute respiratory distress antagonists antiviral property Apoptosis appear ARDS Blood blood pressure bosentan Combination COVID-19 COVID-19 associated ARDS database decrease Deterioration drug Endothelin Endothelin receptor antagonists Epoprostenol Google Scholar help IMPROVE Infection inhibit inhibitors investigated literature lung Lung epithelial cells lung lesion Meta-analysis oedema Oxygenation PAH Patient PDE-5 inhibitors prostacyclin pulmonary arterial hypertension pulmonary artery Randomized controlled trials receptor reduce Respiratory function Result Riociguat Severe case severe SARS-CoV-2 syndrome synergism targeted therapy therapy Treatment ventilation/perfusion
[DOI] 10.1016/j.biopha.2021.112592 [Article Type] Review article

Interrelationship between 2019-nCov receptor DPP4 and diabetes mellitus targets based on protein interaction network

단백질 상호 작용 네트워크를 기반으로 2019-NCOV 수용체 DPP4와 당뇨병 대상 간의 상호 관계

Article

Published on 2022-01-072022-08-31
Journal: Scientific Reports [Category] 바이오마커,

[키워드] added Affect ALB Analysis analyzed antagonists ApoB carried Cluster cluster analysis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection cross database diabete diabetes Diabetes Mellitus Dipeptidyl peptidase-4 DPP4 Drug development Epidemiology Final final analysis functional GeneCard Genome genomes glucagon glucagon signaling pathway high mortality highest human coronavirus IL-6 IL-6 antagonist IL6 inhibitor initial INS insulin Interaction involved KEGG Kyoto LEP management module Ontology Outcomes research Pathway analysis patients patients with diabete patients with diabetes Protein receptor Receptor binding reduce risk of death secretion selected Signaling significantly higher STRING target targets was obtained with COVID-19
[DOI] 10.1038/s41598-021-03912-6 PMC 바로가기 [Article Type] Article

Elevated resting heart rate as independent in-hospital prognostic marker in COVID-19

COVID-19에서 독립적인 병원 내 예후 마커로서의 안정시 심박수 상승

Article

Published on 2022-01-012022-09-11
Journal: Cardiology journal [Category] SARS, 치료기술,