Immunoinformatics and Molecular Docking Studies Predicted Potential Multiepitope-Based Peptide Vaccine and Novel Compounds against Novel SARS-CoV-2 through Virtual ScreeningResearch Article Published on 2021-02-262022-10-27 Journal: BioMed Research International [Category] [키워드] Analysis analyzed antigenic epitope antigenic site approach attack authority B-cell epitope binding affinity binding domain binding energy binding interaction Compound conserved coronavirus coronavirus protein coronavirus vaccine CoVs CTL epitope cytotoxic death disease docked complex docking complex drug drug target epitope exhibited exhibiting food Genome HLA Human immunoinformatics inhibit investigated linker mammal MERS-CoV MHC-I molecular docking multiepitope vaccine Multiple new strain novel pathogenic virus peptide peptide vaccine peptide-based vaccine Potential predict predicted Protein Replication reported Result RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus Screening selected sequence specific treatment spike target the SARS-CoV-2 virus unique variety was performed was used [DOI] 10.1155/2021/1596834 PMC 바로가기 [Article Type] Research Article
Immunoinformatics and Molecular Docking Studies Predicted Potential Multiepitope-Based Peptide Vaccine and Novel Compounds against Novel SARS-CoV-2 through Virtual ScreeningResearch Article Published on 2021-02-262022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] Analysis analyzed antigenic epitope antigenic site approach attack authority B-cell epitope binding affinity binding domain binding energy binding interaction Compound conserved coronavirus coronavirus protein coronavirus vaccine CoVs CTL epitope cytotoxic death disease docked complex docking complex drug drug target epitope exhibited exhibiting food Genome HLA Human immunoinformatics inhibit investigated linker mammal MERS-CoV MHC-I molecular docking multiepitope vaccine Multiple new strain novel pathogenic virus peptide peptide vaccine peptide-based vaccine Potential predict predicted Protein Replication reported Result RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus Screening selected sequence specific treatment spike target the SARS-CoV-2 virus unique variety was performed was used [DOI] 10.1155/2021/1596834 PMC 바로가기 [Article Type] Research Article
Covid-19, heat shock proteins, and autoimmune bullous diseases: a potential link deserving further attentionComment Published on 2021-01-012022-10-04 Journal: Cell stress & chaperones [Category] SARS, 신약개발, [키워드] acting acute respiratory distress Anti-inflammatory antigenic epitope Autoimmune Autoimmune disease autoimmune disorder Autoimmunity blistering bullous COVID-19 cytokine described disease Evidence heat heat shock protein heat shock proteins human proteins mechanism molecular pathophysiological pathophysiology patients reported SARS-CoV-2 Shock syndrome Treatment virus [DOI] 10.1007/s12192-020-01180-3 PMC 바로가기 [Article Type] Comment
T and B cell Epitope analysis of SARS‐CoV‐2 S protein based on immunoinformatics and experimental researchOriginal Article Published on 2020-12-152022-10-29 Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] Analysis Antigen antigenic epitope antigenicity antigens antiviral therapy B cell B cell epitopes can be used caused complex conserved COVID‐19 develop docking effective Fatality rate highest HLA identify immunoinformatics induce Interaction isolate lack leucocyte Molecular dynamics simulation morbidity and mortality Novel coronavirus pandemic peptide peptide epitope predicted Prevent Research S protein SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 selected T and B cell epitopes T cell T cell epitope T cell epitopes T cell immune response T cell response target Vaccine Vaccine design [DOI] 10.1111/jcmm.16200 PMC 바로가기 [Article Type] Original Article
Identification B and T-Cell epitopes and functional exposed amino acids of S protein as a potential vaccine candidate against SARS-CoV-2/COVID-19SARS-CoV-2/COVID-19에 대한 잠재적 백신 후보로서 B 및 T-Cell 에피토프 및 S 단백질의 기능적 노출 아미노산 식별Article Published on 2020-11-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 신약개발, [키워드] Amino acid amino acids antigenic epitope Antiviral strategies B cell epitope B cell epitopes bioinformatics Cancer cardiovascular disease caused chronic respiratory disease combating Combination coronavirus coronavirus disease COVID-19 COVID-19 virus develop diabetes disease disease spread effective epitope Epitopes eradication functional Genome human cell identification Infection Infectious disease Mild mild to moderate moderate MOST novel vaccines peptide peptides positive-sense positive-sense RNA viruses problem Protein receptor recombinant vaccine respiratory Respiratory disease Respiratory illness RNA virus RNA viruses S protein SARS-CoV-2/COVID-19 selected single-stranded spike Spike protein surface protein T and B cell epitopes prediction T cell T cell epitopes Treatment treatments for COVID-19 Vaccine vaccine candidate Vaccine design viruses [DOI] 10.1016/j.micpath.2020.104459 PMC 바로가기 [Article Type] Article
Determine the Potential Epitope Based Peptide Vaccine Against Novel SARS-CoV-2 Targeting Structural Proteins Using Immunoinformatics ApproachesMolecular Biosciences Published on 2020-10-152022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Against Analysis analyzed antigenic epitope antigenic site approach B-cell epitope binding binding affinity caused China corona virus disease 2019 coronavirus CoV COVID-19 CoVs CTL cytotoxic diagnosed disease docking complex effective envelope epitope high mortality rate HLA Human immunoinformatics introduced mammal MHC-I new strain novel pathogenic virus peptide Peptide vaccines positive Potential predict predicted Replication RNA genome RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus spike structural protein targeting unique Vaccine variety Wuhan [DOI] 10.3389/fmolb.2020.00227 PMC 바로가기 [Article Type] Molecular Biosciences
Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2, the etiologic agent of COVID-19 pandemic: an in silico approachBioinformatics Published on 2020-07-272022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome antigenic epitope applied approach average B-cell epitope binding bioinformatics candidate vaccine chimeric Chimeric Peptide Vaccine codon optimization coronavirus coronavirus disease Coverage COVID-19 Cytokines demonstrated docking E protein Ethnic groups expression IFN-γ IgG1 IgG2 IgM IL-2 Immune receptor immune response in silico Approach International mRNA Muti-epitope pandemic peptide predicted proliferation Proteins public health emergency SARS-CoV-2 secondary structure T-cell T-cell epitope T-helper cell TLR3 TLR4 Vaccine vaccine candidate Vaccine design WHO World Health Organization [DOI] 10.7717/peerj.9572 PMC 바로가기 [Article Type] Bioinformatics
Does Early Childhood Vaccination Protect Against COVID-19?Molecular Biosciences Published on 2020-06-052022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Adults Against Amino acid Analysis antigenic epitope caused children coronavirus disease COVID-19 Diseases experimental analysis glycoprotein homologous hospitalized COVID-19 patients humans Humoral immunity Hypothesis Immunity less measles MMR mumps neutralizing antibody pandemic provide required Respiratory system rubella rubella virus SARS-CoV-2 sequence sequence homology spike susceptible target the disease the SARS-CoV-2 vaccination Vaccine virus [DOI] 10.3389/fmolb.2020.00120 PMC 바로가기 [Article Type] Molecular Biosciences
Epitope‐based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics studyResearch Published on 2019-11-082022-10-30 Journal: Journal of Translational Medicine [Category] Coronavirus, [키워드] allele Analysis Antigen antigenic epitope antigenicity Antiviral strategies B-cell epitopes binding combating computational approach Computational approaches conserved country docking effective epitope highest highly antigenic HLA HLA-B7 allele Host identify immunogenic Infection Infection prevention Interaction isolate Isolation kidney infection leukocyte linear B-cell epitope lung MERS-CoV MHC Middle East peptide positive predicted receptors respiratory Result RNA virus S protein S protein epitope Saudi Arabia single-stranded South Korea Spike protein T cell epitope T-and B-cell epitopes T-cell epitopes Vaccine Vaccine design [DOI] 10.1186/s12967-019-2116-8 PMC 바로가기 [Article Type] Research
The antigenic property of the H5N1 avian influenza viruses isolated in central ChinaResearch Published on 2012-08-062023-05-31 Journal: Virology Journal [Category] Fulltext, [키워드] antigenic drift antigenic epitope Avian influenza virus [DOI] 10.1186/1743-422X-9-148 PMC 바로가기 [Article Type] Research