antiviral therapies – Page 2 – Communicable Diseases Research

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

SARS-CoV-2 단백질에 대한 BioID 파생 근접 상호작용체

Article

Published on 2022-03-152022-09-11
Journal: Viruses
[Category] SARS, 신약개발, 유전자 메커니즘,

[키워드] Analysis antiviral therapies antivirals assist association BioID caused Cell cells cellular cellular pathway COVID-19 COVID-19 pandemic drug library enrichment analysis expressing Follow-up Functional enrichment analyses Health Host host cell host cells human lung identify Interaction interactome labeling lung cancer mechanism Novel coronavirus novel coronavirus SARS-CoV-2 Pathogenesis Protein Proteins proteome proteomic proximity labeling. reported responsible SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 proteins SARS-CoV-2 viral the SARS-CoV-2 TurboID understanding valuable resource Viral proteins was used website
[DOI] 10.3390/v14030611 PMC 바로가기 [Article Type] Article

Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2

SARS-CoV-2에 감염된 상피 조직 패치에 대한 항바이러스 타이밍, 효능 및 이질성 효과의 다중 스케일 모델

Article

Published on 2022-03-142022-09-11
Journal: Viruses
[Category] SARS, 치료제,

[키워드] Affect agent agent-based model Antiviral antiviral therapies antiviral therapy Cell cell-to-cell variability cellular cellular metabolism cellular uptake dosage dose Effect Efficacy epithelial Epithelial Tissue Frequency homogeneous include Infection likelihood lowest lung tissue metabolism metabolite Model mPBPK multiscale model outcome outcomes parameters patch permeability pharmacokinetic potency predict Remdesivir SARS-CoV-2 significantly Super-spreader tissue tissue model treat Treatment treatment initiation Treatment outcome Variability Variation viral infection viral infections virtual tissue simulation.
[DOI] 10.3390/v14030605 PMC 바로가기 [Article Type] Article

Differing pan-coronavirus antiviral potency of boceprevir and GC376 in vitro despite discordant molecular docking predictions

불일치 분자 도킹 예측에도 불구하고 Boceprevir 및 GC376의 상이한 범-코로나 바이러스 항 바이러스 효능

Brief Report

Published on 2022-02-162022-09-10
Journal: Archives of Virology
[Category] COVID19(2023년), Fulltext, SARS, 치료제,

Antiviral Targeting of Varicella Zoster Virus Replication and Neuronal Reactivation Using CRISPR/Cas9 Cleavage of the Duplicated Open Reading Frames 62/71

Article

Published on 2022-02-122023-05-24
Journal: Viruses
[Category] Fulltext, 두창, 수두, 홍역,

[키워드] AAV antiviral therapies CRISPR/Cas9 genome cleavage latency Reactivation Varicella zoster virus
[DOI] 10.3390/v14020378 PMC 바로가기 [Article Type] Article

Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values

리툭시 맙 치료 후 연장 된 SARS-COV-2 감염 : 정량적 바이러스 배양 및 사이클 임계 값과 관련된 치료 중재에 대한 임상 과정 및 반응

Case Reports

Published on 2022-02-052022-09-01
Journal: Antimicrobial Resistance and Infection Control
[Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antiviral therapies antiviral therapy approach B-cells clearance Clinical course Clinical parameters complex coronavirus correlated COVID-19 patient COVID-19 patients COVID-19 vaccination Cycle threshold value detection diagnostics highlight Immunocompromised patient Immunosuppressed Immunosuppression implication infection control Infection prevention maintenance nasopharyngeal swabs Oropharyngeal oropharyngeal or nasopharyngeal swabs parameters Patient PCR cycle Prevention and control Prolonged prolonged viral shedding Quantitative question raise recent respiratory reverse transcriptase risk factor RNA RT-PCR SARS-CoV-2 SARS-COV-2 infection Sequencing severe acute respiratory syndrome Coronavirus Steroids suggested supplementary material Therapeutic approach therapeutic intervention Therapeutics threshold vaccination Viral viral clearance viral culture viral shedding virus whole genome Whole genome sequencing
[DOI] 10.1186/s13756-022-01067-1 PMC 바로가기 [Article Type] Case Reports

Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells

목시덱틴과 이버멕틴은 Vero E6 세포에서 SARS-CoV-2 복제를 억제하지만 인간의 1차 기관지 상피 세포에서는 억제하지 않습니다

Article

Published on 2022-01-182022-09-11
Journal: Antimicrobial Agents and Chemotherapy
[Category] SARS, 치료제,

[키워드] ALI alleviate anti-parasitic Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral effect antiviral therapies bronchial caution Cell cell entry Concentration COVID-19 disease COVID-19 patient COVID-19 patients drug epithelial cells Evidence exhibited experiment following head Head-to-head comparison Health Organization High-dose Human humans in vitro in vitro model in vitro result in vivo Infection inhibit SARS-CoV-2 Interpretation Ivermectin limit Moxidectin moxidectin. performed regimen respiratory epithelial cells SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease shown switching therapy these compound these compounds treat Treatment triggered unlikely Vero Cell Vero cells Vero E6 VERO E6 cells virus World Health Organization
[DOI] 10.1128/AAC.01543-21 PMC 바로가기 [Article Type] Article

Plitidepsin as a successful rescue treatment for prolonged viral SARS-CoV-2 replication in a patient with previous anti-CD20 monoclonal antibody-mediated B cell depletion and chronic lymphocytic leukemia

이전에 항-CD20 단일클론 항체 매개 B 세포 고갈 및 만성 림프구성 백혈병이 있는 환자에서 장기간 바이러스 SARS-CoV-2 복제에 대한 성공적인 구조 치료제로서의 플리티뎁신

Case Reports

Published on 2022-01-102022-09-10
Journal: Journal of Hematology & Oncology
[Category] SARS, 바이오마커, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected anti-CD20 Anti-CD20 monoclonal antibody Antiviral antiviral drug antiviral therapies antiviral therapy B cell CD19 CD20 chronic lymphocytic leukemia compassionate use coronavirus coronavirus disease Course COVID-19 COVID-19 pneumonia deficiency develop hematological Hematological malignancies Host immune Immune deficiencies Immunosuppressed Infection leukemia Lymphocytic leukemia male monoclonal monoclonal antibodies Patient Plitidepsin Pneumonia Population Prolonged viral replication resolved respiratory SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 replication Severe COVID-19 pneumonia supplementary material Support toxicities treated Treatment treatment with anti-CD20 undetectable Viral Viral load
[DOI] 10.1186/s13045-021-01220-0 PMC 바로가기 [Article Type] Case Reports

Comparing Outcomes of Two Antiviral Therapy Combinations among COVID-19 Patients

Comparative Study

Published on 2022-01-072022-10-27
Journal: BioMed Research International
[Category] COVID-19,

Comparing Outcomes of Two Antiviral Therapy Combinations among COVID-19 Patients

Comparative Study

Published on 2022-01-072022-10-27
Journal: BioMed Research International
[Category] Coronavirus, COVID-19, SARS,

Comparing Outcomes of Two Antiviral Therapy Combinations among COVID-19 Patients

COVID-19 환자의 2 개의 항 바이러스 요법 조합의 결과 비교

Comparative Study

Published on 2022-01-072022-09-10
Journal: BioMed Research International
[Category] 치료제,