Phylogenetic analysis of 17271 Indian SARS-CoV-2 genomes to identify temporal and spatial hotspot mutations17271 인도 SARS-CoV-2 게놈의 계통 발생 분석을 통해 시간 및 공간 핫스팟 돌연변이 식별Article Published on 2022-03-282022-09-11 Journal: PLoS ONE [Category] SARS, 변종, [키워드] affected aligned Analysis biological function Biological functions carried changes in Characteristics coding region coding regions country COVID Entropy evaluate evaluated followed by functional hotspot identify India MAFFT moderate Multiple sequence alignment Mutation mutations Nextstrain Non-synonymous Patient performed Phylogenetic analysis PolyPhen-2 Protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequence second wave sequence Sequence alignment sequences SNP SNPs stability vaccination virus strains [DOI] 10.1371/journal.pone.0265579 PMC 바로가기 [Article Type] Article
WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinomaArticle Published on 2022-03-092022-10-04 Journal: Cell Death Discovery [Category] 바이오마커, [키워드] Bile duct cancer Biological functions CCK-8 Cell Cholangiocarcinoma chromatin immunoprecipitation Clinical prognosis correlated detect Effect expressed expression expression pattern facilitate Hepatocellular carcinoma ICC IHC immunofluorescence immunohistochemistry intrahepatic investigated Mechanisms of disease Metastasis molecular mechanism MYC NDFIP1 Oncogenes overexpression Patient performed poor prognosis potential mechanisms potential therapeutic target predict progression proliferation promote promoter region Protein protein level reduce reported rescued reveal target tissue tissues Transwell tumor progression Ubiquitylation upregulated upregulation were used WWP1 [DOI] 10.1038/s41420-022-00882-0 PMC 바로가기 [Article Type] Article
Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection가용성 면역 체크포인트는 COVID-19 및 HIV 감염이 있는 과음 알코올 사용자의 조절이 잘 안 됩니다.Review Published on 2022-02-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] alcohol alcohol consumption alcohol-associated liver disease (ALD) antibacterial immunity antibodies Antiretroviral therapy ART balance binding biological function Biological functions biological significance Biomarker Biomarkers blockade blocking antibodies bloodstream Cancer circulating competition COVID-19 COVID-19 patient COVID-19 patients disease Diseases dysregulated dysregulation Effect Efficacy elevated Evidence exacerbate focus form Health healthy heavy alcohol user HIV HIV infection ICP Imbalance immune Immune cell immune cells immune checkpoint immune defense immune microenvironment immune regulation immune responses in vitro in vivo Infectious diseases Inflammation inhibitory Interaction malignant cell malignant cells membrane membrane-bound mRNA occur Pandemics pathophysiological condition pathophysiological conditions peripheral circulation plasma Plasma levels PLHIV protease public health reducing regulate Regulation Regulatory secretion self-tolerance severity of COVID-19 significantly soluble immune checkpoint stimulatory storm Surveillance Therapies Tumor user with HIV [DOI] 10.3389/fimmu.2022.833310 PMC 바로가기 [Article Type] Review
The Role of Selenium in Pathologies: An Updated ReviewReview Published on 2022-01-272022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] adverse effects Alzheimer’s disease Amino acid antioxidants Biological functions Cancer Cardiovascular disorders Clinical outcome Concentration COVID-19 diabetes Diseases Ebselen Fertility gender medicine GPx Hormones Infection Inflammation involved Mental Disorders modulating outcome over pathology prognostic reactive oxygen specy reduced risk Regulation reported required review role ROS SARS-CoV-2 Selenium TrxR variety [DOI] 10.3390/antiox11020251 PMC 바로가기 [Article Type] Review
A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics AnalysisCOVID-19/천식 동반 질환에 대한 루테올린의 약리학적 메커니즘 탐색을 위한 실용적인 전략: 시스템 약리학 및 생물정보학 분석 결과Immunology Published on 2022-01-072022-09-11 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activities Against AKT1 ALB Anti-inflammatory Antiviral approach Asthma binding binding activity Bioactivity Bioinformatics analysis biological activity Biological functions blood circulation Cancer Cell cell growth Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 Defense disease drug candidate Effect effective EGFR enrichment analysis ErbB evaluate Evidence experiments finding growth Health HIF-1 IL-6 immune regulation immune responses indicate indicated Inflammation Luteolin MAPK mechanism molecular docking analysis molecular mechanism oxidative stress pathway Patient PD-1 PD-L1 performed Pharmacology Physicochemical properties physicochemical property poor prognosis predicted Protein–protein interaction RAGE reducing Regulation Replication Research SARS-COV-2 infection Signaling Strategy suggested susceptibility System system pharmacology target targets TNF Toll-like receptor TP53 VEGFA virus [DOI] 10.3389/fimmu.2021.769011 PMC 바로가기 [Article Type] Immunology
NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cellsSARS-CoV-2의 NSP9는 숙주 세포에서 뉴클레오포린 62 역학 및 기능을 방해하여 핵 수송을 약화시킵니다Article Published on 2022-01-012022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 유전자 메커니즘, [키워드] association attenuate biological function Biological functions blocked cell fate cell line complexes contributed correlated cytoplasm Diseases ectopic Endoplasmic reticulum expression function host cell host cells modulation molecular molecular mechanism molecular mechanisms NF-κB NPC Nsp9 nuclear nuclear envelope nuclear pore Nucleoporin NUP62 over-expression overexpression p65 p65. Protein reduction regulate reported SARS-CoV-2 SARS-COV-2 infection subcellular subcellular distribution subunit These data TNF-α translocation Transport [DOI] 10.1016/j.bbrc.2021.11.046 PMC 바로가기 [Article Type] Article
Host Factor Interaction Networks Identified by Integrative Bioinformatics Analysis Reveals Therapeutic Implications in COPD Patients With COVID-19Pharmacology Published on 2021-12-232022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accumulating Analysis bioinformatics analyses Bioinformatics analysis Biological functions comorbid disease Comorbidities Comorbidity condition conducted COPD COVID-19 COVID-19 pandemic data sets database Dexamethasone drug effective interventions enrichment analysis evidence of Factor Factors Host host factor interaction networks Identified Interaction Intersection management mechanism molecular mechanism network network analysis nitric oxide Ontology Pathway enrichment analysis Perspective progesterone protein-protein interaction Respiratory disease signaling pathway Transcription [DOI] 10.3389/fphar.2021.718874 PMC 바로가기 [Article Type] Pharmacology
Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses박쥐와 인간 코로나바이러스 ORF8 단백질 Ig-유사 도메인의 결정 구조는 면역 반응의 다양성에 대한 통찰력을 제공합니다Immunology Published on 2021-12-172022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, 변종, [키워드] accessory protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assays bat biochemical biological function Biological functions CD14 Characteristics Combined conditions conformations coronavirus COVID-19 crystal crystal structure crystal structures Crystallography Disulfide Diversity domain Effect human coronavirus human peripheral blood immune immune responses in vitro insight Interaction interfere isoforms monocyte Monocytes Mutagenesis ORF8 ORF8 protein ORF8 proteins Peripheral blood Protein RaTG13 residue respiratory response responsible RNA genome SARS-CoV-2 severe acute respiratory syndrome Coronavirus Structure subsequent the epidemic variant Viral [DOI] 10.3389/fimmu.2021.807134 PMC 바로가기 [Article Type] Immunology
Cellular Deubiquitylating Enzyme: A Regulatory Factor of Antiviral Innate ImmunityMicrobiology Published on 2021-12-132022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome Antiviral antiviral response Biological functions cellular coronavirus deubiquitylating enzymes domain DUB enzyme Factor family immune evasion Inflammasome inflammasomes Innate innate immune response Innate immunity Interaction mechanism NLR NLRP3 pattern-recognition receptors protease Proteins PRRs receptor regulated Regulation SARS-CoV-2 substrate therapeutic viral infection virus [DOI] 10.3389/fmicb.2021.805223 PMC 바로가기 [Article Type] Microbiology
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cellsmicroRNA는 표적 세포로 거의 전달되지 않는 세포 외 소포의 작은 성분입니다.Research Article Published on 2021-12-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Alter analyzed applied approach Biological functions Blood cells carried Cell cell line cell lines cell types cell-to-cell communication cellular cellular membrane cellular membranes contribute defined document effector effectors Evidence EVs Exosome Exosomes experiments extracellular vesicle Extracellular vesicles fraction functional FUSE had no majority mammalian cells messenger RNAs microRNA MicroRNAs Microvesicles miRNA miRNAs mRNA mRNAs packaged purified Quantitative recipient regulate RNAs Sensitivity and specificity stability target target cell target cells target mRNA Transcriptome Vesicle vesicles Viral viral miRNAs [DOI] 10.1371/journal.pgen.1009951 PMC 바로가기 [Article Type] Research Article