The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish [DOI] 10.3390/ijms231710130 PMC 바로가기
Impact of the COVID-19 pandemic on hepatitis B and C elimination: An EASL surveyResearch article Published on 2022-09-012022-10-05 Journal: JHEP Reports [Category] 치료기술, [키워드] Antiviral treatment Care cascade Clinical Center clinical centers clinical unit collected comparable conducted country COVID-19 COVID-19 pandemic diagnose Diagnosis effort European evaluate expected expressed Factors Frame HBsAg HBV HBV DNA HCV Hepatitis hepatitis B Hepatitis B virus hepatitis C virus Impact limitation liver maintain measure pandemic public health questionnaire reduction representing Result RNA target targets the WHO transferred Treatment Viral hepatitis WHO WHO elimination targets World Health Organization [DOI] 10.1016/j.jhepr.2022.100531 [Article Type] Research article
Immunosuppressed non-responders to two doses of mRNA SARS-CoV-2 vaccines achieve an immune response comparable to those of immunocompetent individuals after a third doseArticle Published on 2022-09-012022-11-15 Journal: Hormones (Athens, Greece) [Category] COVID19(2023년), SARS, 진단, [키워드] anti-CD20 antibody response against Antibody titer appear Autoimmune disorders cancers cascade cell-mediated immune comparable disease dose elevated Glucocorticoids Hematological malignancies immune response Immunocompromised Immunosuppressed Immunosuppression individual induce inhibitor methotrexate MMF monoclonal antibody MOST mRNA mRNA SARS-CoV-2 vaccines. neutralizing antibody non-responder Patient proportion Protein Rapamycin recipient S protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Signaling solid cancers solid organ transplant suggested the SARS-CoV-2 the SARS-CoV-2 virus third dose transplantation Treatment Vaccine Vaccines variety while [DOI] 10.1007/s42000-022-00365-y PMC 바로가기
Novel aspects of sepsis pathophysiology: NETs, plasma glycoproteins, endotheliopathy and COVID-19Review article Published on 2022-09-012022-10-05 Journal: Journal of pharmacological sciences [Category] 바이오마커, [키워드] accumulating acute phase addition ARDS Blood cells cascade caused Coagulation complex COVID-19 defined develop drug dysregulated effective therapy endotheliopathy Evidence functional glycoprotein Health Health Organization Histidine-rich glycoprotein (HRG) host response HRG Infection life-threatening multifactorial NET NETs Neutrophil extracellular trap neutrophil extracellular traps (NETs) novel organ dysfunction organs pathophysiology plasma plasma protein problem Protein Proteins Regulation Sepsis targets vascular endothelial cell [DOI] 10.1016/j.jphs.2022.06.001 [Article Type] Review article
Novel covalent and non-covalent complex-based pharmacophore models of SARS-CoV-2 main protease (M pro) elucidated by microsecond MD simulations마이크로초 MD 시뮬레이션으로 밝혀진 SARS-CoV-2 주요 프로테아제(M pro)의 새로운 공유 및 비공유 복합 기반 약전 모델Article Published on 2022-08-182022-09-11 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] active site Analysis AUC values cascade category caused complex conformational changes COVID-19 treatment develop Diagnosis docking drug target effective effort exhibited highest in silico inhibitor inhibitors Interaction knowledge M pro MD simulation MM/PBSA molecular molecular dynamics molecular dynamics simulations novel pandemic pocket Protein protein-ligand protocol reported residue SARS-CoV-2 SARS-CoV-2 main protease the SARS-CoV-2 therapeutic agent Treatment strategies Virtual screening [DOI] 10.1038/s41598-022-17204-0 PMC 바로가기 [Article Type] Article
Connecting the dots between inflammatory cascades of obesity and COVID-19 in light of mortal consequences-a review치명적인 결과에 비추어 비만의 염증성 폭포와 COVID-19 사이의 점 연결 - 리뷰Review Published on 2022-08-012022-09-12 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 adipocyte adverse effects age angiotensin-converting enzyme 2 BMI body mass index cardiometabolic cascade children Coagulation combating complications consequence coronavirus disease correlation country COVID-19 Cytokine storm D-dimer determinant endothelial Epidemics Factors fatal disease greater immunological implicated individual individuals Inflammatory inflammatory cascade inflammatory parameters inflammatory pathology intensive care less Major molecular obese obesity organization pathology pathophysiological PBM pharmacological treatment RAAS reported resource risk Stress suggested therapeutic options therapy Treatment triggering vessel WAT. [DOI] 10.1007/s11356-022-21461-x PMC 바로가기 [Article Type] Review
Harnessing Natural Products by a Pharmacophore-Oriented Semisynthesis Approach for the Discovery of Potential Anti-SARS-CoV-2 Agents잠재적인 Anti-SARS-CoV-2 제제의 발견을 위한 약동학 지향 반합성 접근법에 의한 천연물 활용Article Published on 2022-07-112022-09-11 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 치료제, [키워드] agent anti-SARS-CoV-2 Anti-SARS-CoV-2 Agents antiviral activity applied approach assembly cascade Cell complex structure creation Domino Reactions EpiC HPA inhibited mechanism natural natural products oridonin pharmacophore Potential product Rearrangement Remdesivir SARS-CoV-2 replication Semisynthesis suggested unique Wolff Wolff Rearrangement. [DOI] 10.1002/anie.202201684 PMC 바로가기 [Article Type] Article
Drug-Target Network Study Reveals the Core Target-Protein Interactions of Various COVID-19 TreatmentsArticle Published on 2022-07-062022-10-04 Journal: Genes [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis Bronchoalveolar lavage fluid cascade caused Cell cell membrane conducted core coronavirus disease COVID-19 COVID-19 symptom CTD curated database death rate Diseases downstream cellular signaling drug Drug discovery drug treatment drug-target drug-target network drugs effort function Genes Human interconnected genes involved knowledge lung Macrophage medications mitigate network Numerous overlapped overlapping pandemic pharmacological target PPI protein-protein interaction receptors reduce risk SARS-CoV-2 virus severe COVID-19 significantly single-cell Symptom T cell target gene text mining [DOI] 10.3390/genes13071210 PMC 바로가기 [Article Type] Article
Making cough count in tuberculosis care Reviews Published on 2022-07-062022-10-05 Journal: Communications Medicine [Category] 진단, [키워드] Acoustic Biomarker Care cascade Clinical management condition cough detect disease Epidemiology Health IMPROVE increasingly Making management outcome Patient public health respiratory diseases Stage Support Tuberculosis while [DOI] 10.1038/s43856-022-00149-w [Article Type] Reviews