Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral ClearanceArticle Published on 2022-09-022022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] antibody B cell basophils CD4 T cells CD4+ CD4+ T cell CD4+ T cells cellular component correlated count COVID-19 Critical cytokine profile Delayed determinant disease deterioration help hospitalised patient Humoral response IL-9 immune activation immune parameter less longitudinal design magnitude MIF moderate Monocytes naïve naïve CD4+ T cell neutralising Neutralising Antibodies Neutrophils pro-inflammatory risk stratification SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease T cell Th2 the timing tissue damage viral clearance [DOI] 10.3390/cells11172743 PMC 바로가기
Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV: A cross-sectional studyHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 단면 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antiretroviral therapy appear ART CD4+ T cell CD4+ T cells CD4+ T-cell chemiluminescence Chinese control group COVID-19 COVID-19 vaccine cross-sectional delta variant Delta variants detect Efficacy and safety enzyme enzyme immunoassay healthy individual Human immunodeficiency virus IgG IgM antibodies IgM antibody immunoassay immunodeficiency immunogenicity inactivated indicated individual Mild multivariable analysis NAb Neutralizing neutralizing antibody Odds ratio PLWH proportion Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific IgG self-limiting seropositive Seropositivity serum IgG serum levels Side effect Side effects significantly higher T cells titers vaccination was used wild-type SARS-CoV-2 with HIV [DOI] 10.1002/jmv.27872 PMC 바로가기 [Article Type] Article
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity주산기 인간 면역결핍 바이러스에 감염된 청소년 및 젊은 성인은 뚜렷한 BNT162b2 메신저 RNA 코로나바이러스 질병 2019 백신 면역원성을 나타냅니다.Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adolescent anti-SARS-CoV-2 humoral antibody Antigen Antigen-specific T cells Antiretroviral therapy ART baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine CD4+ T cell CD4+ T-cell CD40L Cellular responses characterized Cluster collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated dose Efficacy eligibility evaluated expand feature Follow-up group HCs healthy control HIV HIV-infected patient HIV-infected patients Human Human immunodeficiency virus humoral immune response Immunity immunization immunodeficiency virus immunogenicity involved messenger Messenger RNA molecules mononuclear cell mononuclear cells mounted mRNA of BNT162b2 Olink perinatally HIV-infected patients. Peripheral blood Peripheral blood mononuclear cells plasma samples Population populations profile protein level protein levels proteomic proximity extension assay Regulation respiratory response responses RNA RNA coronavirus Safety Sample SARS-CoV-2 SARS-CoV-2 antibody second dose severe acute respiratory syndrome Coronavirus study groups T cell T cells vaccination Vaccine Vulnerable populations were assessed [DOI] 10.1093/cid/ciac408 PMC 바로가기 [Article Type] Article
Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall ResponseSARS-CoV-2 감염 및 백신 회수 반응 이후 중간 기억 B 세포의 지속적인 유지Article Published on 2022-08-102022-09-12 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed antibodies antibody Antigen B cell B cell response booster CD21 CD27 CD4 CD4+ CD4+ T cell Cell correlated COVID-19 demonstrated determine elicited help highlight immune response Immunity immunization individual level infected individual Infection intermediate Kinetics Longevity longitudinal maintain maintenance memory B memory B cell memory B cells neutralization Neutralizing antibodies neutralizing antibody Pandemics persistence persistent phenotype Postinfection Protective Protein recall receptor recovered respond response SARS-CoV-2 SARS-COV-2 infection secreted significantly spike T cells the SARS-CoV-2 triggered vaccination [DOI] 10.1128/jvi.00760-22 PMC 바로가기 [Article Type] Article
T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patientsResearch article Published on 2022-08-012022-10-05 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Admission Analysis B cell CD4+ T cell circulating Course COVID-19 creatinine Critical Critical disease decrease disease elevated higher risk Hospitalized hospitalized COVID-19 patient identify IL-6 immune response increased risk Infection marker men no significant difference Older Patient patients hospitalized percentage plasma predict progressed progression Result risk SARS CoV2 subset T cell T-cell Th17 cell Th17 cells therapy These data Tocilizumab two group women worsening [DOI] 10.1016/j.ejim.2022.06.001 [Article Type] Research article
Neurovascular injury with complement activation and inflammation in COVID-19COVID-19에서 보체 활성화 및 염증으로 인한 신경 혈관 손상Article Published on 2022-07-292022-09-12 Journal: Brain : a journal of neurology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accompanied Activation acute respiratory syndrome adherent aggregate aggregation Analysis astrogliosis autopsy study B cell Brain CD4+ T cell CD8+ T cells cellular change changes in characterized classical complement complement deposition Complement pathway complexes coronavirus coronavirus disease COVID-19 cytotoxicity determine died Endothelial cell First wave hindbrain humoral immune response immune complex immunohistochemistry Infection Inflammation Injury Macrophage mechanism microthrombi Neuroinflammation neurological manifestation neuronal Neurovascular neurovascular injury. nodule pandemic pathological change pathology pathophysiological mechanisms Patient patients died performed perivascular Platelet Platelets Post-mortem predominant Quantitative regions SARS-CoV-2 Serum protein short duration Vascular Vascular damage vascular leakage widespread [DOI] 10.1093/brain/awac151 PMC 바로가기 [Article Type] Article
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 Research Published on 2022-07-282022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, 치료법, [키워드] acute infection acute respiratory distress Amino acid Analysis Applying ARDS carbon source CD4+ T cell CD4+ T cells COVID-19 Glycolysis highlight host adaptation immune response Impaired individual induce infected with SARS-CoV-2 infections influence interferon-γ ketogenic metabolism mice Mortality oxidative phosphorylation Patient promote provide Pulmonary infection pulmonary viral reducing severe COVID-19 severe respiratory infections skewed survival syndrome T cell T cell dysfunction T cell response [DOI] 10.1038/s41586-022-05128-8 [Article Type] Research
Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant어린이의 조상 SARS-CoV-2에 대한 특정 CD4+ T 세포 반응은 나이가 들어감에 따라 증가하고 베타 변이체에 대한 교차 반응성을 나타냅니다Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accompanied Activation activation induced marker (AIM) activation-induced marker activation-induced markers age ancestral Antiviral average Beta Beta variant beta variants Blood CD4+ CD4+ T cell children Control convalescent coronavirus COVID-19 cross-reactivity Cytokines cytometric disease course Effective vaccines Flow global health granzyme granzyme B HCoV Health human coronavirus human coronavirus (HCoV) IFN-γ immune response increase Infection infection rate infection rates marker Mild mononuclear cell PBMC pediatric peptide peripheral Peripheral blood Peripheral blood mononuclear cells reduced reduction response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant secreted cytokine secretion seronegative show social distancing measures Specific stimulated T cell T cell responses T cells the SARS-CoV-2 vaccination variant variant of concern (VOC) viral variant VoC was reduced were used [DOI] 10.3389/fimmu.2022.867577 PMC 바로가기 [Article Type] Article
The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T CellsReview Published on 2022-07-142023-07-10 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), [키워드] CD4+ T cell COVID-19 follicular helper T cell. SARS-CoV-2 viral infection [DOI] 10.3389/fcimb.2022.953022 PMC 바로가기 [Article Type] Review
Targeting TFH cells in human diseases and vaccination: rationale and practice Reviews Published on 2022-07-112022-10-05 Journal: Nature Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] allergens antibody antibody affinity Antigen approach Autoantigens B cell B cells boost CD4+ T cell Cell cytokine disease disease pathogenesis Efficacy facilitate human disease Humoral immunity Infection knowledge lymphomagenesis maturation mechanisms memory pathogen clearance pathogenic protective antibody response receptor regulate Regulation reservoirs response Support survival T cell targeting TCR therapy Vaccine [DOI] 10.1038/s41590-022-01253-8 [Article Type] Reviews