The impact of COVID-19 non-pharmaceutical interventions on HIV care continuum in China: An interrupted time series analysisResearch article Published on 2022-12-012022-10-05 Journal: The Lancet Regional Health - Western Pacific [Category] 변종, [키워드] 95% CI affected Analysis Antiretroviral therapy ART Care CD4 count CD4 counts CD4+ T cell China collected continuum COVID-19 decrease diagnose diagnoses Diagnosis disease early stage effort evaluate expected finding foundation funding HIV hospital implementation increase in Infectious disease Interrupted time series analysis interval Intervention maintain majority male median time natural non-pharmaceutical interventions (NPIs) NPI NPIs occurred outcome outcomes Poisson Prophylaxis public health emergency reached Region Regression model Science study period time interval time intervals Transmission were recorded [DOI] 10.1016/j.lanwpc.2022.100569 [Article Type] Research article
Heterologous boosting with third dose of coronavirus disease recombinant subunit vaccine increases neutralizing antibodies and T cell immunity against different severe acute respiratory syndrome coronavirus 2 variants코로나바이러스 질병 재조합 소단위 백신의 세 번째 용량으로 이종 부스팅은 다양한 중증 급성 호흡기 증후군 코로나바이러스 2 변이체에 대한 중화 항체 및 T 세포 면역을 증가시킵니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-RBD IgG anti-S booster vaccination CD4+ T cell components composite pattern coronavirus coronavirus disease COVID-19 COVID-19 vaccinations COVID-19 vaccine dose effective epitope Epitopes evaluated Evidence help Heterologous heterologous boosting homologous Humoral immunity Immune escape Immunity immunization strategy immunological in some inactivated Inactivated vaccine increase magnitude NAb NAbs natural infection Neutralizing Neutralizing antibodies neutralizing antibody neutralizing capacity omicron pandemic prime-boost strategy produced RBD IgG respiratory subunit Subunit vaccine T cell T cell response T cells titre vaccination Vaccination strategies Vaccination strategy Vaccine Vaccine-induced immunity variant variants of concern waned [DOI] 10.1080/22221751.2022.2048969 PMC 바로가기 [Article Type] Article
Adaptive immunity to SARS-CoV-2 infection: A systematic reviewArticle Published on 2022-10-102022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome adaptive Adaptive immunity addressed Alpha Antigen article B cell Biomarker case-control study caused CD4+ T cell CD8+ CD8+ T lymphocytes Cell cell types Characteristics clinical benefits Cohort studies coronavirus coronavirus disease Course COVID-19 Critically ill Critically ill patient cross-sectional CXCL9 Cytokines database disease English Evidence experimental evidence follicular HLA-DR humoral Humoral immunity IL-10 IL-13 IL-15 IL-17 IL-1α IL-2 IL-21 IL-22 IL-23 IL-4 IL-5 IL-7 immune system Immunity immunological Immunological memory immunopathological in vitro assays individuals inflammatory mediator involved leukocyte Ligand lymphocyte marker mild case Necrosis poor prognosis predominant produced programmed cell death progression Protein Regulatory T cell responsible SARS-CoV-2 SARS-COV-2 infection SciELO secretion severity Spanish subpopulation systematic review T helper T helper cell T lymphocyte T-cell Response Tfh TGF-β Th1 Th17 Th2 the antibody the disease TNF-α Treg tumor growth Vaccine variable [DOI] 10.3389/fimmu.2022.1001198 PMC 바로가기
Enhanced immune responses following heterologous vaccination with self-amplifying RNA and mRNA COVID-19 vaccinesArticle Published on 2022-10-042022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation antibody Antibody Response Antibody titre antigen exposure baseline benefit binding BNT162b2 boost CD4+ T cell CD8+ Cellular immune response clinical trial Course COVID-19 Delta dose ELISA ELISPOT enhanced global public health glycoprotein Heterologous highest humoral immune memory immune response immunological increase in individual majority marker median mRNA mRNA COVID-19 vaccine mRNA vaccination mRNA vaccine naïve natural infection neutralising antibody titre omicron participant Participants PCR proportion question receiving recruited response RNA SARS-CoV-2 vaccine second dose seroconverted significantly higher subject the SARS-CoV-2 titre vaccination Vaccination strategy Vaccine variants were measured wildtype [DOI] 10.1371/journal.ppat.1010885 PMC 바로가기
NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responsesArticle Published on 2022-10-032022-11-15 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adaptive immunity CD4+ CD4+ T cell CD4+ T cells CD8+ T cell Cell Cellular immune response characteristic characterization circulating correlated COVID-19 demonstrated detectable dose Efficacy follicular full-length SARS-CoV-2 functional humoral immune responses IFN-γ immune immunization immunology individual induce magnitude Matrix-M NVX-CoV2373 Protective Protein response responses robust SARS-CoV-2-neutralizing antibody spike trimer subset T cells Th1 cell trials vaccinated individual vaccination Vaccine [DOI] 10.1172/JCI160898 PMC 바로가기
Protein vaccine NVX-CoV2373 elicits functional T cell immunityArticle Published on 2022-10-032022-11-15 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis Antibody Response association CD4+ CD4+ T cell CD8+ T cell Cell characterized circumvent dose Effect elicit elicited enrolled follicular functional humoral immune responses Immunity individual induce mRNA vaccine neutralizing antibody titers NVX-CoV2373 recognizing Region response robust SARS-CoV-2 antigen SARS-CoV-2 vaccine T cell T cell responses Trial Vaccine vaccine dose [DOI] 10.1172/JCI163614 PMC 바로가기
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificityArticle Published on 2022-10-032022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] airway analyzed antiviral immunity Breakthrough infection CD4+ T cell CD8+ COVID-19 COVID-19 vaccinee feature highlight Immunity immunological induce Infection nasal nasal mucosa persistence phenotype Primary infection Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 vaccination SARS-CoV-2-infected cell specificity suppress T cell T cell response vaccination vaccinee [DOI] 10.1084/jem.20220780 PMC 바로가기
IL-6 drives T cell death to participate in lymphopenia in COVID-19Research article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] activated T cells affecting analyzed caused CD4+ T cell change Course COVID-19 COVID-19 cytokine storm COVID-19 patients Critical death disease Disease progression early stage Hospitalization hospitalized COVID-19 patient ICU care IFN-γ IL-1β IL-6 Immune status induce infected patients Infection laboratory result lymphopenia maintain observation Patient patients patients with COVID-19 plasma concentration predict pyroptosis Randomly reduction reduction in Result SARS-CoV-2 selected severity supported T cell T cell lymphopenia T lymphocyte T-cell the disease TNF-α [DOI] 10.1016/j.intimp.2022.109132 [Article Type] Research article
Immunogenicity profiling and distinct immune response in liver transplant recipients vaccinated with SARS-CoV-2 inactivated vaccinesArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] anti-RBD antibody CD19 CD19+ CD3+ CD3+ CD19+ cell CD4+ cell CD4+ T cell Cell cells cellular immunity Clinical characteristics Concentration CXCL10 DNT effector memory enrolled groups humoral immune profiling immune response immune system immunogenicity immunotype inactivated Inactivated vaccine innate immune response liver liver transplant recipient Lymphocyte count monocyte NAb National Neutralizing Neutralizing antibodies neutralizing antibody plasma Population positive proportion provided recipient recipients reported responders responses SARS-CoV-2 SARS-CoV-2 inactivated vaccines severe adverse event single-cell T-cell three groups time TNF-alpha Type vaccination vaccination schedule were recorded [DOI] 10.3389/fimmu.2022.954177 PMC 바로가기
Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemicArticle Published on 2022-09-142022-11-15 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Antibody titers Antigen CD4 CD4+ T cell common cold common cold coronavirus common cold Coronaviruses comparable coronavirus Endemic Frequency immune immune memory immune response infection prevalence influence longitudinal analysis magnitude memory outcome pandemic performed RBD-specific IgG response reactivity repeated response responses SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection Steady state steady state. sustained T cells Vaccine development [DOI] 10.1016/j.chom.2022.07.012 PMC 바로가기