Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV ‐2 infected cells and their response to antiviral therapySARS-CoV-2 감염 세포에서 소포체 스트레스와 NF-kB 활성화와 항바이러스 치료에 대한 반응Special Issue Published on 2021-08-132022-09-10 Journal: Iubmb Life [Category] MERS, SARS, 치료제, [키워드] Activation antiviral therapy c‐Jun caspase Cell cell interaction cells cellular cellular processe cellular stress response change characterized COVID‐19 cytopathic Endoplasmic reticulum expression host cell hpi identify inducer infected cell infection process Inflammation Inflammatory inhibition Interaction investigated MAPK MAPK signaling molecular nelfinavir NF‐kB occur Pathogenesis pathway Protease inhibitor Protein protein expression Remdesivir SARS‐CoV‐2 infection SARS‐CoV‐2 Signal transduction Signaling stimulate Stress stress response therapy transcriptional regulation unfolded protein response UPR VERO‐E6 cells Viral viral infection viral replication virus [DOI] 10.1002/iub.2537 PMC 바로가기 [Article Type] Special Issue
Long and short non-coding RNA and radiation response: a reviewReview article Published on 2021-07-012022-10-05 Journal: Translational research : the journal of laboratory [Category] 비임상, [키워드] alteration anti-sense oligonucleotides arising ASOanti-sense oligonucleotides binding biofluids Biomarker CADcoronary artery disease Cancer Cell cellular processe cellular stress response changes in circRNAcircular RNA circular RNA Coronary artery disease DCAdicentric chromosome assay diabete diagnostic dicentric chromosome assay disease Disease progression DNA Effect EMTepithelial-to-mesenchymal transition epithelial-to-mesenchymal transition evaluate examined expression level expression profile form Future gray (unit) Gygray (unit) interactions introduced invasive ionizing radiation IRionizing radiation lncRNA lncRNAlong noncoding RNA Long long noncoding RNA Messenger RNA microRNA miRNA miRNAmicroRNA modulate modulation mRNA mRNAMessenger RNA mRNAs ncRNA ncRNAnoncoding RNA ncRNAs non-coding RNA Non-small cell lung cancer noncoding RNA NSCLCnon-small cell lung cancer oxidative stress PBMCperipheral blood mononuclear cells Peripheral blood mononuclear cells piRNApiwi-interacting RNA piwi-interacting RNA prognostic biomarker Proteins Radiation radiation exposure Radiotherapy reactive oxygen species regulate reported Research RNA RNA expression RNA interference RNAiRNA interference ROSreactive oxygen species serum short hairpin RNA shown shRNAshort hairpin RNA siRNAsmall interfering RNA Small interfering RNA small nuclear RNA small nucleolar RNA snoRNAsmall nucleolar RNA snRNAsmall nuclear RNA stability Stress TBItotal body irradiation therapeutic use thought total body irradiation transfer RNA tRNAtransfer RNA untranslated region UTRuntranslated region [DOI] 10.1016/j.trsl.2021.02.005 [Article Type] Review article
Heparan Sulfate Proteoglycans in Viral Infection and Treatment: A Special Focus on SARS-CoV-2바이러스 감염 및 치료에서 헤파란 황산염 프로테오글리칸: SARS-CoV-2에 대한 특별 초점Review Published on 2021-06-182022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 진단, [키워드] Activation assist attachment Bacterial biosynthetic cellular processe cellular processes chemokines complex composed core protein Cytokines downstream Effects Enzymes expression Extracellular matrix focus functional functions generate glycoprotein Glycoproteins Growth factors heparan sulfate heparan sulfate proteoglycans host cell host cells human diseases Infection Interaction internalization involved knowledge life cycle ligands matrix proteins molecular mechanism molecular mechanisms Pathogenesis pathogenesis of SARS-CoV-2 Pathogens plethora Protein Proteins Proteoglycan proteoglycans receptor Regulatory SARS-CoV-2 SARS-COV-2 infection Signaling Spread sulfate target therapeutic strategy therapy tissue tissues translate variety Viral viral pathogens virus virus viruses [DOI] 10.3390/ijms22126574 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 ExpressionPharmacology Published on 2021-04-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Activation Cell cellular processe Chloroquine chroloquine comprehensive analysis COVID-19 COVID-19 infection data set downregulate DUSP1 DUSP5 expression Gene Expression Genes help human airway epithelial immune Immune cell infected with SARS-CoV-2 lower expression lowest MAPK mechanism mitogen-activated protein kinase NF-κB NF-κB signaling NFkB NFκB non-steroidal anti-inflammatory drug other coronavirus pathway Pathways phosphatase Proinflammatory cytokine Protein reduction regulate regulatory pathway SARS-CoV-2 the SARS-CoV-2 TNF-α transcript Treatment [DOI] 10.3389/fphar.2021.631879 PMC 바로가기 [Article Type] Pharmacology
Circular RNA–MicroRNA–MRNA interaction predictions in SARS-CoV-2 infectionSARS-CoV-2 감염에서 원형 RNA-MicroRNA-MRNA 상호작용 예측Article Published on 2021-03-172022-09-10 Journal: Journal of Integrative Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral cellular processe circRNA Circular coronavirus defined differential expression expressed feature Gene regulation hairpins higher eukaryotes host–pathogen interactions human miRNA human miRNAs identify Infection Interaction investigated involved machine learning mechanism microRNA MicroRNAs miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs organism predict Regulation respiratory RNA SARS-CoV-2 SARS-COV-2 infection secondary structures severe acute respiratory syndrome Coronavirus shown Viral viral mRNA viral mRNAs virus viruses [DOI] 10.1515/jib-2020-0047 PMC 바로가기 [Article Type] Article
In Silico , In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell FusionSARS-CoV-2 스파이크/인간 ACE2 복합체, 바이러스 진입 및 세포 융합 모니터링을 위한 In Silico, In Vitro 및 In Cellulo 모델Article Published on 2021-02-252022-09-10 Journal: Viruses [Category] MERS, 변종, 치료기술, 치료제, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral agent Antiviral agents approach approaches assays association binding biochemical BLI Cell Cell fusion cell line cell surface cellular cellular processe cellular processes Clinical research complex Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 detect determine etiologic agent expressing flow cytometry fusion help house in silico in vitro Infection Interaction kinetic Lentiviral vector Model modulation MONITOR monitoring pandemic parameter pseudotyped Replication Research respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Spike Protein S Spike/ACE2 complex the cell the SARS-CoV-2 therapeutic target transduction assay variant Viral viral entry viral spike protein viral spike protein S virus virus entry [DOI] 10.3390/v13030365 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 infection remodels the host protein thermal stability landscapeSARS-CoV-2 감염은 숙주 단백질 열 안정성 풍경을 개조합니다Article Published on 2021-02-162022-09-10 Journal: Molecular Systems Biology [Category] MERS, 치료제, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alteration aryl hydrocarbon hydroxylase biosafety Cell cell cycle cellular cellular processe cellular processes change changes in condition coronavirus displaying effective framework global change handling Health heat shock chaperone Host host protein host proteins human pathogen imperative Infection Interaction Microbiology, Virology & Host Pathogen Interaction microtubule molecular Pathogens Protein proteome provide Regulation Replication respiratory rhapontigenin RNA splicing SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus stability suppressed tanespimycin targets therapy thermal thermal stability Vaccine [DOI] 10.15252/msb.202010188 PMC 바로가기 [Article Type] Article
Impact of obesity and SARS-CoV-2 infection: implications for host defence – a living reviewShort Communication Published on 2021-01-212022-10-29 Journal: Oxford Open Immunology [Category] COVID-19, [키워드] acute respiratory syndrome alteration baseline cellular processe chronic inflammation Chronic low-grade inflammation coronavirus COVID-19 disease healthy Host IAV immune Immune cell immune response Impact implication individuals Infection Inflammation Influenza lipid metabolism metabolism obese patient obesity pandemic pathophysiology promote Respiratory virus infection SARS-CoV-2 severe coronavirus disease severe SARS-CoV-2 therapy Vaccine design viral propagation virus virus [DOI] 10.1093/oxfimm/iqab001 PMC 바로가기 [Article Type] Short Communication
Mapping the SARS-CoV-2–Host Protein–Protein Interactome by Affinity Purification Mass Spectrometry and Proximity-Dependent Biotin Labeling: A Rational and Straightforward Route to Discover Host-Directed Anti-SARS-CoV-2 TherapeuticsSARS-CoV-2–숙주 단백질–단백질 상호작용체 매핑(Affinity Purification Mass Spectrometry 및 Proximity-Dependent Biotin Labeling: Host-Directed Anti-SARS-CoV-2 치료제 발견을 위한 합리적이고 간단한 경로)Review Published on 2021-01-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advent affinity Affinity purification affinity-purification mass spectrometry Antiviral approach approved drug cellular cellular processe cellular processes coronavirus coronavirus disease COVID-19 Drug discovery Drug repurposing effective emerging experiment Follow-up Generation help high resolution Host host cell host cells host protein identify Interaction interactome life cycle mapping mass mass spectrometry mirage offer outbreak PPI protein interactions protein–protein interactions protein–protein interaction proteomics proximity-dependent biotin labeling (BioID) reduce regulated respiratory route SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spectrometry target targets therapeutic option therapeutic targets Therapeutics Viral viral life cycle virus virus entry virus–host interaction virus–host interactions [DOI] 10.3390/ijms22020532 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host DefensesSARS-CoV-2는 호스트 방어를 억제하기 위해 스플라이싱, 번역 및 단백질 트래피킹을 방해합니다.Article Published on 2020-11-252022-09-11 Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bind cause cell membrane cellular cellular processe coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt Disruption domain engage function Host host defenses Infection Interaction interfere interferon interferon response leads molecular basis mRNA mRNA splicing mRNA translation nsp1 nsp16 NSP8 Nsp9 Protein protein trafficking protein translation respiratory Respiratory disease ribosomal RNA ribosome RNA RNA-protein interactions RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 snRNA splicing suppress the cell the interferon translation Viral viral infection [DOI] 10.1016/j.cell.2020.10.004 PMC 바로가기 [Article Type] Article