In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic CoronavirusesReview Article Published on 2021-06-212022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] binding cell entry cell line cell receptor cellular protease CoV CoVs ENCODE family Coronaviridae Genome host cell in vitro model information inhibiting knowledge membranes methodology Model offer Pathogenesis positive-sense Protein RNA virus RNA viruses structural proteins the S protein the Spike therapeutic approaches therapeutic intervention tropism viral tropism [DOI] 10.1155/2021/8856018 PMC 바로가기 [Article Type] Review Article
The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway EpitheliaResearch Article Published on 2021-05-112022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Air-liquid interface Amino acid cellular protease coronavirus Culture Deletion Donor Dynamics epithelia Evidence FCS furin cleavage site HAE healthy Human human airway epithelia human airways Infection Lung disease maintain mutated patients primary human airway processed released retained S1 and S2 S1/S2 boundary SARS-CoV-2 selective Site stability subunit transcript Transcriptome unique upstream Vero Vero cells viral genome viral transcriptome virion while [DOI] 10.1128/mBio.01006-21 PMC 바로가기 [Article Type] Research Article
High expression of SARS-CoV-2 entry factors in human conjunctival goblet cells인간 결막 잔 세포에서 SARS-CoV-2 진입 인자의 높은 발현Review Published on 2021-04-012022-09-11 Journal: Experimental eye research [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 auxiliary cell type cell types cellular protease co-expressed conjunctival Conjunctival goblet cell COVID-19 expression of SARS-CoV-2 Factor goblet Goblet cell goblet cells help Immunity involved molecular mechanism priming protease receptor SARS-CoV-2 cell SARS-COV-2 infection SARS‐CoV‐2 Sequencing Serine serine 2 shown single-cell TMPRSS2 TMPRSS2. transmembrane transmembrane protease serine 2 virus entry was performed [DOI] 10.1016/j.exer.2021.108501 PMC 바로가기 [Article Type] Review
Prostate adenocarcinoma and COVID‐19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS‐CoV‐2전립선 선암종 및 COVID-19: SARS-CoV-2에 대한 감수성에서 TMPRSS2 발현의 가능한 영향Original Article Published on 2021-02-202022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] TMPRSS2 gene androgen Cancer cancer cell cancer patient Cancer patients carcinoma cellular protease Clinical severity Colon conducted COVID‐19 COVID‐19 domains enrichment expresse expressed expression expression profile expression profiles facilitate followed by functional functional annotation highest highlighting host cells Impact increased expression Influenza influenza A involved isoform lung mechanism OMIM organs outcome overexpression pancreas pandemic Pathogenesis pathway Pathways Patient patients physiological play roles predict promoter Prostate prostate adenocarcinoma Prostate cancer prostate gland Protective Protein Regulation salivary salivary gland SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 seminal vesicle Serine small intestine stomach Structure survival susceptibility the disease Therapeutic strategies therapeutic strategy tissue tissues TMPRSS2 TMPRSS2 expression transcriptional trypsin tumorigenesis Vesicle Viral viral entry virus viruses [DOI] 10.1111/jcmm.16385 PMC 바로가기 [Article Type] Original Article
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusionSARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다Research Article Published on 2021-01-252022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ACE2 ACE2 receptor activate activated acute respiratory syndrome coronavirus Amino acid Antiviral antiviral therapies attachment binding Cell cell-cell fusion cells cellular protease cellular proteases cleavage cleaved cocktail coronavirus COVID-19 pandemic CRISPR CRISPR-Cas9 Donor drug focus furin furin cleavage furin inhibitor furin inhibitors furin knockout cell furin knockout cells furin protease fusion fusion peptide host cell host cell membrane host cell receptor infect infected cell Infection inhibitor inhibitors motif multibasic site multinucleated cells mutant Mutation peptide pre-activation Prevent promote protease protease TMPRSS2 Protein reduce reduces required Research respiratory responsible reveal S protein S-mediated cell-cell fusion SARS-CoV-2 SARS-CoV-2 antiviral therapy SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread syncytia formation target cell the S protein the SARS-CoV-2 thought TMPRSS2 TMPRSS2 protease treat triggered triggering unique Viral viral infection Viral protein viral spread virus virus entry virus entry process virus-host membrane fusion [DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article
Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptomSARS-CoV-2 감염 매개체와 말초 후각 수용체의 동시 발현: COVID-19 증상으로서 후각 상실 이상의 잠재적 의미Article Published on 2020-09-012022-09-11 Journal: International journal of molecular medicine [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome adipose Adipose tissue analysed angiotensin Anosmia atlas bladder Brain cathepsin L caused Cell cellular protease Clinical studies clinical study COVID‐19 CTSL damage disease enzyme expressed expression expression profile facilitated function GeneMANIA healthy heart highlight host cells host cells) human host cell human host cells Hyposmia implication in vitro Infection interact kidney liver Local Loss of Smell mechanism mediators nasal New olfactory olfactory bulb olfactory receptor OR51E2 pancrea pancreas periphery plethora Potential Profiling Prostate protease receptor required respiratory Serine serine 2 Severe acute respiratory syndrome significantly Symptom Testis Thyroid tissue tissues TMPRSS2 transmembrane transmembrane protease serine 2 upregulated [DOI] 10.3892/ijmm.2020.4646 PMC 바로가기 [Article Type] Article
Single‐cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: A potential pathway of COVID‐19 infection인간 신장의 단일 세포 RNA 시퀀싱 분석은 ACE2 수용체의 존재를 나타냅니다: COVID-19 감염의 잠재적 경로Original Article Published on 2020-08-032022-09-10 Journal: Molecular Genetics & Genomic Medicine [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression Activation Acute kidney injury AKI Analysis Canonical marker genes caused Cell cells cellular cellular protease Characteristics Cluster COVID‐19 COVID‐19 infection COVID‐19 patients COVID‐19 digestive system enrichment analysis Epidemic epithelial cells Evidence evidence of expressed expressing Gene ontology genome sequence glomerular human kidney Imbalance Infection Injury KEGG kidney Kidney injury liver lung marker gene mechanism neutrophil Novel coronavirus organ outbreak parietal cells Pathogenesis pathway Pneumonia priming provided proximal proximal convoluted tubule proximal tubule RAS renal reported reproductive reproductive system Result reveal RNA sequencing SARS‐CoV‐2 SARS‐CoV‐2 scRNA‐seq separated Seurat similarity tissue TMPRSS2 urinary system Urine was performed was used were used Wuhan [DOI] 10.1002/mgg3.1442 PMC 바로가기 [Article Type] Original Article
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 Research Published on 2020-07-222022-10-05 Journal: Nature [Category] SARS, 치료제, [키워드] activate Activation acute respiratory syndrome African green monkey antiviral intervention Calu-3 caused cell line cellular protease Chloroquine coronavirus coronavirus disease COVID-19 death develop disease drug expression human lung human lung cell Infection infection with SARS-CoV-2 inhibit lung lung cell pandemic pathway patients PROTECT SARS-CoV-2 SARS-COV-2 infection Spread target TMPRSS2 treat Treatment unlikely Vero Cell [DOI] 10.1038/s41586-020-2575-3 [Article Type] Research
Interaction of certain monoterpenoid hydrocarbons with the receptor binding domain of 2019 novel coronavirus (2019-nCoV), transmembrane serine protease 2 (TMPRSS2), cathepsin B, and cathepsin L (CatB/L) and their pharmacokinetic propertiesArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV ACE2 addition Analysis binding binding energy cathepsin cathepsin B cathepsin L caused cellular protease coronavirus coronavirus disease COVID-19 cross death docking dose drug-likeness effective evaluated IC50 inhibit Interaction liver cells molecular interaction monoterpene P-glycoprotein pharmacokinetic predicted Receptor binding domain serine protease Spike protein target target protein TMPRSS2 toxic effect transmembrane serine protease [DOI] 10.3906/biy-2005-46 PMC 바로가기 [Article Type] Article
Lessons Learned to Date on COVID-19 Hyperinflammatory Syndrome: Considerations for Interventions to Mitigate SARS-CoV-2 Viral Infection and Detrimental HyperinflammationImmunology Published on 2020-05-292022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] 2019-nCoV Antiviral antiviral immune response Asymptomatic boost caused cellular protease China complications coronavirus COVID-19 COVID-19 progression COVID-19 severity Cytokine release syndrome Date determine develop disease Disease progression drug drugs targeting event Factor help host cell hyperinflammation Hyperinflammatory immune include individual Inflammatory responses inhibit SARS-CoV-2 Intervention key factor lesson Lungs mechanism of action monoclonal antibody multifactorial occur pandemic pro-inflammatory cytokine randomized clinical trials reported Repurposed drug SARS-CoV-2 SARS-CoV-2 replication serine protease inhibitor severe COVID-19 Spread the timing transmission of SARS-CoV-2 Treatment strategies viral infection [DOI] 10.3389/fimmu.2020.01131 PMC 바로가기 [Article Type] Immunology