Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 VariantsArticle Published on 2022-10-012022-11-16 Journal: The protein journal [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 adopted affinity antibody biochemical characterization Degradation help host cell receptor host receptor immune response immunological IMPROVE increase in infected individual interact Intervention medical intervention mutant Mutation mutations natural selection neutralizing antibody parental protease Rapid RBD receptor Receptor binding domain responses SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant sensitivity the RBD thermal stability Transmissibility understanding variant variants of concern variants. [DOI] 10.1007/s10930-022-10073-6 PMC 바로가기
Characterization of pathogen-inactivated COVID-19 convalescent plasma and responses in transfused patientsArticle Published on 2022-10-012022-11-15 Journal: Transfusion [Category] COVID19(2023년), SARS, 진단, [키워드] 28-day mortality acute respiratory syndrome administration adverse effects adverse event adverse events antibody antibody assay Antibody Response Antibody titers Antigen assays binding case-control study CCP Characteristics characterization Control Controlled trial convalescent convalescent plasma coronavirus COVID-19 COVID-19 convalescent plasma died disease severity Donor donors enrolled evaluated group had no heterogeneous hospital Hospitalized immune response Immunosuppressed median median age Microarray NAb Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing antibody assays neutralizing capacity not affect pathogen-reduction treatment. Patient Pneumonia recipient recipients response responses SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV2 single-center survival symptom onset transfused transfusion treated Treatment variable with COVID-19 [DOI] 10.1111/trf.17083 PMC 바로가기
Analysis of Cross-sectional and Longitudinal HLA and Anti-viral Responses After COVID Infection in Renal Allograft Recipients: Differences and CorrelatesArticle Published on 2022-10-012022-11-15 Journal: Transplantation [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody calculated changes in characterization characterized class coronavirus coronavirus disease COVID COVID-19 COVID-19 diagnosis cross-sectional decrease determine difference dominant HLA HLA-DQ IgA IgG IgG1 IgG2 IgG3 IgM immune Immunoglobulin Infection isotype kidney transplant recipient longitudinal median MOST Multiplex assay nucleocapsid protein Organ transplant Patient patients with COVID-19 Prevalence reactive recipient Region renal reported response SARS-CoV-2 antigens SARS-CoV-2 epitope semi-quantitative significantly statistically significant the spike protein [DOI] 10.1097/TP.0000000000004277 PMC 바로가기
Characterization of coagulopathy and outcomes in cancer patients with severe COVID -19 illness: Longitudinal changes in hospitalized cancer patientsArticle Published on 2022-10-012022-11-15 Journal: Cancer Medicine [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 1:1 Anderson blood cell count Cancer cancer patient Cancer patients CBC center change changes in characterization clinical clinical observations Coagulopathy Complete correlated COVID COVID-19 COVID-19 illness COVID-19 patient Critical CRP death disease elevated feature fibrinogen FIVE future risk had more help hematological hematological cancer Hospital admission Hospital stay Hospitalization Hospitalized IL-6 inflammatory markers interleukin-6 lack longitudinal Lymphocyte count management measure mechanical ventilation mechanism Mortality neutrophil Non-COVID-19 outcome outcomes Peripheral blood Platelet prognostic Prognostic factor required Retrospective analysis risk Risk assessment Serum ferritin severe COVID-19 illness Stratification survival thrombosis Thrombotic complications unique viral infection Viral infection. with COVID-19 [DOI] 10.1002/cam4.4753 PMC 바로가기
Characterization of serotonin as a candidate biomarker of severity and prognosis of COVID-19 using LC/MS analysisResearch article Published on 2022-10-012022-10-05 Journal: Journal of pharmacological sciences [Category] 바이오마커, 진단, [키워드] Analysis analyzed Biomarker characterization Concentration concentrations coronavirus disease COVID-19 COVID-19 severity diagnostic disease severity effective high mortality management moderate disease pandemic pathophysiology Patient patients with COVID-19 Prognosis prognostic biomarker Serotonin serum severe COVID-19 severe disease severity and prognosis significantly lower worsened [DOI] 10.1016/j.jphs.2022.06.005 [Article Type] Research article
Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu InfectionArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome addition antibody Antiviral antiviral immunity characterization convalescent sera coronavirus coronavirus 2 coronavirus disease COVID-19 determine E484K elicited immune resistance immune resistance. individual induce induced Infection Mu variant Mutation notable resistance respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Spike protein the SARS-CoV-2 vaccination Vaccine variant [DOI] 10.1093/infdis/jiac053 PMC 바로가기
Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD ProteinArticle Published on 2022-09-182022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 addition affinity angiotensin-converting enzyme 2 antibodies antibody fragment Antibody therapeutics Antigen bi-paratopic VNAR binding binding affinities characterization classical complexes COVID-19 Delta domain epitope exhibited FIVE flexible fusing fusion gel filtration immunized inaccessible motif omicron Protein RBD RBD binding receptor recognize reported SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Screening shark spike Spike protein the RBD the SARS-CoV-2 variants variants. VNAR wildtype [DOI] 10.3390/ijms231810904 PMC 바로가기
Characterization of Entry Pathways, Species-Specific Angiotensin-Converting Enzyme 2 Residues Determining Entry, and Antibody Neutralization Evasion of Omicron BA.1, BA.1.1, BA.2, and BA.3 VariantsArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 ACE2 receptor addition angiotensin-converting enzyme 2 animal ACE2 receptors antibody breakthrough infections Cell characterization Chloroquine D614G D614G variant Determining dose elicit endosomal entry ENhance exhibit greater groups immune evasion Infection inhibitor less Lineage mechanism mRNA vaccination mRNA vaccine neutralization neutralization resistance neutralization titer Neutralizing antibodies neutralizing antibody omicron Pathways pseudovirus public health SARS-CoV-2 SARS-CoV-2 Omicron variants sensitivity spike mutation Spread Substitution substitutions tested TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Transmissibility Transmission vaccination Vaccine vaccine booster variant variants virus entry virus entry pathways. zoonotic [DOI] 10.1128/jvi.01140-22 PMC 바로가기
Structural- and Site-Specific N- Glycosylation Characterization of COVID-19 Virus Spike with StrucGPArticle Published on 2022-09-132022-11-15 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] addition Algorithm analyzed characterization COVID-19 COVID-19 virus glycan glycosylation Infection Mannose 6-phosphate mapped motif Previous studies previous study Protein residues SARS-CoV-2 Sequencing spike Structure structures Support the S protein trimer [DOI] 10.1021/acs.analchem.2c02265 PMC 바로가기
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingArticle Published on 2022-09-022022-11-16 Journal: Human Genomics [Category] SARS, 변종, [키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses [DOI] 10.1186/s40246-022-00411-1 PMC 바로가기