High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 PatientsHERV-K(HML-2)의 높은 발현은 COVID-19 환자에서 인터페론을 자극할 수 있습니다Article Published on 2022-05-072022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate activated Affect antiviral immunity blood sample Blood samples Cell cGAS chromosome collected COVID-19 COVID-19 patient COVID-19 patients distribution expressed expression Gene ontology Genes GO analysis healthy healthy controls HERV HERV-K HERV-K (HML-2) HML-2 Host human body IFIT1 IFN-I IFNB1 infected with SARS-CoV-2 Interaction interferon ISG15 mapped marker Next-generation sequencing pathway Patient qPCR regulate SARS-CoV-2 secretion STING Vero Vero cells was performed [DOI] 10.3390/v14050996 PMC 바로가기 [Article Type] Article
A Protective HLA Extended Haplotype Outweighs the Major COVID-19 Risk Factor Inherited From Neanderthals in the Sardinian Population보호 HLA 확장 일배체형은 사르데냐 인구의 네안데르탈인에게서 유전된 주요 COVID-19 위험 요소보다 큽니다Article Published on 2022-04-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] 95% CI analyzed Asymptomatic B*18:01 balance carrier carriers chromosome chromosome 3 Combination combinations Course COVID-19 disease course DRB*03 extended haplotype drug Europe evaluated Evolution Extended Factor Frequency Genetic variant Haplotype healthy high risk HLA HLA class I HLA haplotypes HLA-A HLA-A*02:01 Hospitalization immunogenetic factor incidence increased risk Infection investigated KIR KIR genes KIRs Ligand locus lowest Major mechanism moderate disease Mortality Neanderthal Neanderthal Covid-19 risk haplotype outcome Patient pauci-symptomatic Population predicted Protective protective effect reported risk risk factor rs35044562 variant. Sardinia Sardinian Sardinian controls Sardinian population SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 patient severe disease severe SARS severe SARS-CoV-2 shown thalassemia three-loci extended haplotype turn Vaccines variant [DOI] 10.3389/fimmu.2022.891147 PMC 바로가기 [Article Type] Article
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
Biotin-thiamine responsive basal ganglia disease in the era of COVID-19 outbreak diagnosis not to be missed: A case report코로나19 발병 진단에서 놓쳐서는 안 될 비오틴-티아민 반응성 기저핵 질환: 증례 보고Case Reports Published on 2022-04-012022-09-11 Journal: Brain & development [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis autosomal recessive basal ganglia Biotin Biotin-thiamine responsive basal ganglia disease Case report caused central necrosis characteristic characterized chromosome Coronavirus-2 COVID-19 COVID-19 outbreak death diagnosed Diagnosis disability disease disorder Encephalomyelitis Encephalopathy episode febrile illness Fever ganglia genetic analysis high signal male male child MRI Mutation Necrosis Neurometabolic Patient presenting SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity SLC19A3 suspicion Thiamine Transporter 2 treatable treated triggered viral infection virus infection [DOI] 10.1016/j.braindev.2021.12.003 PMC 바로가기 [Article Type] Case Reports
Spread of hypervirulent multidrug-resistant ST147 Klebsiella pneumoniae in patients with severe COVID-19: an observational study from Italy, 2020-21Observational Study Published on 2022-03-312022-10-05 Journal: Journal of Antimicrobial Chemotherapy [Category] Coronavirus, 임상, [키워드] Bloodstream infections capsular carried chromosome clinical collected Combination Complete COVID-19 COVID-19 patient COVID-19 patients Diagnosis enhancer ESBL genes encoding high mortality Illumina Miseq Infection infection control isolate Italy Klebsiella pneumoniae majority measure Mortality multidrug-resistant outbreak outcome Patient phenotype Plasmid Prospective rectal reported resistance genes Sequencing strain string test Surveillance susceptibility treated university urinary tract infections Urine Ventilator-associated pneumonia was determined was performed whole genome [DOI] 10.1093/jac/dkab495 PMC 바로가기 [Article Type] Observational Study
The major genetic risk factor for severe COVID-19 is associated with protection against HIV심각한 COVID-19의 주요 유전적 위험 요소는 HIV에 대한 보호와 관련이 있습니다Article Published on 2022-03-012022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] carrier carriers CCR5 chemokine receptors chromosome chromosome 3 COVID-19 DNA down-regulated expression genetic risk factor genetic risk factors genetics Haplotype HIV HIV infection initiative lower risk modulate Nature outcome risk severe COVID-19 variant [DOI] 10.1073/pnas.2116435119 PMC 바로가기 [Article Type] Article
Sexual dimorphism in COVID-19: potential clinical and public health implicationsCOVID-19의 성 이형성: 잠재적인 임상 및 공중 보건 영향Review Published on 2022-03-012022-09-12 Journal: The lancet. Diabetes & endocrinology [Category] Fulltext, MERS, 임상, 진단, [키워드] Acute stress binding chromosome Comorbidities complement COVID COVID-19 current difference disease Endocrine Evidence explain expression pattern Follow-up help immune implication increased risk Infectious disease mechanism men Mortality outcomes pandemic Patient patients with COVID-19 progression Protein public health public health measures reaction Reinfection SARS-CoV-2 infections severity severity of COVID-19 Sex Sex difference Sex hormones sexual dimorphism Stratification Surveillance Treatment Vaccines View virus women [DOI] 10.1016/S2213-8587(21)00346-6 PMC 바로가기 [Article Type] Review
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening고처리량 스크리닝 적용을 위한 안정적인 SARS-CoV-2 레플리콘 시스템 구축Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral Antiviral effect antiviral effects Bacterial bacterial artificial chromosome biosafety level Biosafety Level 3 BSL2 BSL3 camostat Cell cell line cell lines cells chromosome compounds condition conditions coronavirus COVID-19 examined exhibited Favipiravir gene encoding In vitro infection inhibited interferon level 3 luciferase luciferase activity molnupiravir Neomycin Novel coronavirus Particles powerful tool produced RdRP RdRp inhibitor Remdesivir Renilla Renilla luciferase replicon reported RNA SARS-coronavirus SARS-coronavirus-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgRNA sgRNAs stable cell stable cell line suppressed the SARS-CoV-2 transient transfection transiently transfected Treatment VeroE6 cells Viral proteins viral replication [DOI] 10.1016/j.antiviral.2022.105268 PMC 바로가기 [Article Type] Article
Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and ReplicationArticle Published on 2022-01-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] A97V antiviral activity autonomous BAC Bacterial Cell culture chromosome clone coronavirus COVID-19 COVID-19 pandemic decrease drug Efficacy exhibited experiments F480L facilitated fluorescent full-length SARS-CoV-2 functional Genes genomic region genomic RNA GFP growth Healthcare system in vitro Infectious virus inhibited membrane modify molecular clone Mutation nanoluciferase non-infectious Nsp12 P323L phenotype platform polymerase polymorphism Protein provide recombinant Remdesivir Replication replicon reporter Research resistance RNA virus SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 susceptibility SARS-CoV-2 variants sequence Substitution susceptibility System transcript Treatment utility Vaccines Vero E6 cell viral gene virus virus isolate [DOI] 10.3390/v14020172 PMC 바로가기 [Article Type] Article
Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population Research Published on 2022-01-112022-10-05 Journal: Journal of Human Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] association cells chromosome Cohort Comorbidity Control COVID-19 COVID-19 disease COVID-19 susceptibility disease disease severity EEA1 Factor Genetic genome-wide significance genotyped Host Host genetic factor Human IL17B immune response in viral Infection Inflammation involved likelihood Linkage disequilibrium LOC643339 loci locus long non-coding RNA Odds ratio Pathogenesis Patient Pneumonia populations recruited required shown Single nucleotide polymorphism small sample size SNP suggested susceptibility threshold with COVID-19 [DOI] 10.1038/s10038-021-01009-6 [Article Type] Research