Clinical sign – Page 2 – Communicable Diseases Research

Human placenta-derived mesenchymal stem cells transplantation in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 (phase I clinical trial): safety profile assessment

Clinical Trial

Published on 2022-07-282022-10-05
Journal: Stem Cell Research & Therapy [Category] COVID19(2023년), SARS, 임상,

Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species

노출 방식은 여러 비인간 영장류 종에서 바이러스 역학에 영향을 미치지만 COVID-19의 호흡기 결과에는 영향을 미치지 않습니다

Article

Published on 2022-07-052022-09-11
Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종,

[키워드] aerosol exposure African African green monkeys AGM AGMs animal model animal models ARDS change Characteristics Chlorocebus clinical clinical response Clinical sign Clinical signs Cohort conserved COVID-19 COVID-19 disease cytokine response demonstrated demonstration develop expand exposure functional greater include infected with SARS-CoV-2 Infection influence intranasal lack lung damage magnitude Medical countermeasures mucosal mucosal exposure myeloid cell Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic status Pathogenesis Pathologies pleuritis Pulmonary pathology reached regenerative Research rhesus rhesus macaques route SARS-COV-2 infection severe disease small particle aerosol species tested therapeutic utility variants variants of concern viral kinetics Viral load
[DOI] 10.1371/journal.ppat.1010618 PMC 바로가기 [Article Type] Article

Association between thrombocytopenia and the severity of Covid-19 infection among hospitalized Egyptian patients

Research article

Published on 2022-07-012022-10-05
Journal: Annals of Medicine and Surgery [Category] 바이오마커,

[키워드] acute respiratory syndrome addition ARDS association cause caused Clinical sign COVID-19 Critically ill Critically ill patient critically ill patients cross-sectional death Disseminated intravascular coagulopathy distress evaluate group hemorrhage Hospitalized hospitalized patients hypoxia Infection Laboratory lung dysfunction occurred outcome parameter Patient patients with COVID-19 Pneumonia radiological evidence Respiratory failure risk Severe acute respiratory syndrome Severe patient severity severity of COVID-19 statistically statistically significant difference symptomatic patient syndrome systemic illness thrombocytopenia virus was done
[DOI] 10.1016/j.amsu.2022.103973 [Article Type] Research article

Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals

외래 및 반려동물의 SARS-CoV-2 감염 및 관련 병변 조사

Article

Published on 2022-07-012022-09-11
Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm animals bronchopneumonia cats cause of death Cell Chain Reaction Clinical sign Combination conducted coronavirus COVID-19 death died disease dogs euthanized Evidence evidence of exotic Human individual Infection investigation laboratory-confirmed SARS-CoV-2 infection lesion lesions mammary Mild Myocardial natural infection necropsies necropsy one health outcome Pneumonia Polymerase chain reaction testing renal renal disease respiratory reverse transcriptase SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance syncytial cell tested tiger Viral virus zoonosis
[DOI] 10.1177/03009858211067467 PMC 바로가기 [Article Type] Article

SARS-COV-2 RBD (Receptor binding domain) mutations and variants (A sectional-analytical study)

SARS-COV-2 RBD(수용체 결합 도메인) 돌연변이 및 변이체(섹션 분석 연구)

Article

Published on 2022-07-012022-09-11
Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] ACE2 receptor Alpha alpha and delta variants Alpha variant Amino acid amino acid substitutions amino acids amplified B.1.1.529 B.1.1.7 binding domain binding the receptor-binding body pain chill chills circulation Clinical outcome clinical outcomes Clinical sign Clinical signs cross-sectional D614G delta variant domain Effect enrolled essential amino acids Fever Frequency highest host cells identify Infection lung involvement mutant strain Mutation mutations N501Y omicron Omicron variant outcomes Pain pangolin Patient qRT-PCR RBD RBD region Receptor-binding domain SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV2 sequenced spike Spike protein strain T478K the patient the RBD the SARS-CoV-2 variant variants variants of concern variants of interest Variation viral infection virus VOCs VOIs
[DOI] 10.1016/j.micpath.2022.105595 PMC 바로가기 [Article Type] Article

OMICRON: Virology, immunopathogenesis, and laboratory diagnosis

OMICRON: 바이러스학, 면역병리학 및 실험실 진단

Review

Published on 2022-07-012022-09-11
Journal: The journal of gene medicine [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed Alpha antibody approach B.1.1.529 Beta Biology Booster vaccine Clinical sign coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 decrease Delta Diagnosis diagnostic dose Gamma Genetic Genome Health Organization Immunopathogenesis immunopathological increased risk Infection Laboratory management Mortality Mutation omicron Omicron variant pediatrics Re-infection receptor binding site respiratory virus risk severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severity Signs and symptoms Spike protein Spread Symptoms therapeutic Transmissibility understanding Vaccine vaccine response Vaccines variant variants variants of concern Virology World Health Organization
[DOI] 10.1002/jgm.3435 PMC 바로가기 [Article Type] Review

Thoracic imaging tests for the diagnosis of COVID‐19

Article

Published on 2022-06-162022-10-06
Journal: Cochrane database of systematic reviews [Category] COVID19(2023년), SARS, 진단,

[키워드] 95% CI 95% confidence interval Accuracy age applicability articles Asymptomatic Asymptomatic individuals cause CDC Chest Chest CT Clinical sign Combination comparison Computed tomography concern COVID‐19 criteria CT findings Definition diagnosing Diagnosis diagnostic Effect eight estimate estimates evaluate evaluated Evidence example excluded Final heterogeneity imaging imaging test indicated individual initial library limit lung MOST participant Participants Pneumonia polymerase chain positive ranged recruited reference reference standard Repository Respiratory illness resulting risk of bia RT‐PCR SARS‐CoV‐2 infection screened searched sensitivity Sensitivity and specificity Seven specificity Stephen Symptoms Thoracic threshold transcriptase University of Bern utility
[DOI] 10.1002/14651858.CD013639.pub5 [Article Type] Article

Experimental Infection of Mink with SARS-COV-2 Omicron Variant and Subsequent Clinical Disease

SARS-COV-2 오미크론 변이체에 의한 밍크의 실험적 감염 및 후속 임상 질환

Article

Published on 2022-06-012022-09-11
Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종,

SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic Cats

SARS CoV-2(Delta Variant) 감염 역학 및 국내 고양이의 면역 병인 발생

Article

Published on 2022-06-012022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2-expressing cell ACE2-expressing cells acute COVID-19 acute infection animal model animal models B.1.617.2 chemokine chemokine signaling circulating Clinical sign Cluster correlated correlation COVID-19 disease COVID-19 disease course Critical cytokine receptor Delta delta variant develop differentially expressed gene Differentially expressed genes disease Disease progression disease transmission Divergence domestic cats dose downstream dysregulated evaluate feline ferrets flexible genetic modification help highlight Host hub genes identify immunopathology include Infection Infectious virus Inflammatory inflammatory pathways inoculated Interaction interactions intranasally Kinetics lesion lesions limitation lung lung tissue Lungs Mild nasal network analysis non-human primates pathology pathway peribronchial Pneumocytes Post-infection Prevent progression pulmonary inflammation pulmonary lesion pulmonary lesions Respiratory disease RNA sequencing SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secretion significantly Spread target therapeutic timepoints transgenic mice translational upregulation variant Vascular endothelium Vasculitis Viral antigen Viral protein virus WGCNA wild-type SARS-CoV-2
[DOI] 10.3390/v14061207 PMC 바로가기 [Article Type] Article

Differential Pathogenesis of SARS-CoV-2 Variants of Concern in Human ACE2-Expressing Mice

인간 ACE2-발현 마우스에서 우려되는 SARS-CoV-2 변이체의 차별적 병인 발생

Article

Published on 2022-05-252022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2-expressing mice acute respiratory syndrome acute respiratory syndrome coronavirus Alpha B.1 B.1 lineage B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Brain caused chemokine chemokines circulating circulating variant Clinical sign concern contagious coronavirus COVID-19 cytokine Cytokines death evaluated exhibited hACE2 Human Infection Inflammation inoculated intranasally K18-hACE2 K18-hACE2 mice less lineages lung Lungs mice mouse-adapted SARS-CoV-2 omicron pandemic Pathogenesis pathogenesis of SARS-CoV-2 question Replication resulting SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity significantly significantly higher significantly lower significantly more survival rate the disease Transcription variant variants of concern virus virus titer
[DOI] 10.3390/v14061139 PMC 바로가기 [Article Type] Article