Integrated microbiome and metabolome analysis reveals the potential therapeutic mechanism of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumoniaArticle Published on 2022-08-262022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] 16S rRNA addition affected amino acids Analysis bile acids change China Clinical treatment coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 current Eicosanoids evaluated fatty acids Gut gut microbiota Host Host immune response immune immune function immune response IMPROVE Inflammation lipid metabolism lung tissue mechanism metabolism metabolite metabolome metabolomic analysis mice Microbiome modulating patients with COVID-19 performed Pneumonia Qing-Fei-Pai-Du decoction reduce reveal Sequencing serum severity shown significantly Spearman correlation analysis Staphylococcus therapeutic therapeutic effect Treatment was performed [DOI] 10.3389/fcimb.2022.950983 PMC 바로가기
Precision oncology for intrahepatic cholangiocarcinoma in clinical practice Research Published on 2022-08-192022-10-05 Journal: British Journal of Cancer [Category] 변종, 유전자 메커니즘, 임상, [키워드] alteration applied approach ARID1A ATM BAP1 BRAF Care CDKN2A CDKN2B Chemotherapy Chemotherapy treatment Cholangiocarcinoma Clinical practice Clinical treatment Combination Deterioration DNA and RNA FGFR2 FGFR3 formalin-fixed paraffin-embedded gene fusion IDH1 IDH2 intrahepatic involved loci molecular NRG1 oncology Patient patients performance status PIK3CA poor prognosis Probability progression receiving Result Sequencing significantly higher SMARCA4 survival target targeted therapy therapy tissue TP53 translated Treatment was performed [DOI] 10.1038/s41416-022-01932-1 [Article Type] Research
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)COVID-19의 긴 COVID/급성 후유증(PASC)을 가진 개인의 증상, 동반질환, 섬유소 아밀로이드 미세응고 및 혈소판 병리의 유병률Article Published on 2022-08-062022-09-11 Journal: Cardiovascular Diabetology [Category] SARS, 진단, 치료기술, [키워드] accompanied acute COVID-19 African amyloid Amyloid fibrin(ogen) analysed Atypical balance blood sample Blood samples Brain capillary cardiovascular disease cholesterol Clinical studies clinical study Clinical treatment co-morbidities Comorbidities Comorbidity comparable Concentration controlled clinical studies coronavirus coronavirus 2019 disease COVID-19 COVID-19 severity determine diabetes Diabetes Mellitus Diagnostic method Diversity dyslipidaemia Early detection effective Efficacy endotheliopathy fatigue female FIBRIN Fluorescence fluorescence microscopy foci Gender Hyperactivated platelets hypertension individual inhibit joint Long Long COVID/PASC morbidities muscle pains ogen PASC pathology Patient patients Platelet platelet hyperactivation Platelets platform provide reducing registry removal reported reversal SARS-COV-2 infection scoring system Shortness of breath South Symptom Symptoms tissues Transport Treatment type 2 diabete Type 2 diabetes mellitus [DOI] 10.1186/s12933-022-01579-5 PMC 바로가기 [Article Type] Article
Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatmentarticle Published on 2022-07-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] Blood–brain barrier cerebral malaria clinical manifestation Clinical treatment neurological damage Plasmodium falciparum [Article Type] article
Efficacy of salmeterol and magnesium isoglycyrrhizinate combination treatment in rats with chronic obstructive pulmonary disease Research Published on 2022-07-192022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료제, [키워드] Adverse reaction airway Anti-inflammatory Bronchoalveolar lavage fluid characterized chronic inflammation chronic obstructive Clinical treatment Combination combination treatment contributing to COPD glucocorticoid Hormones IL-1β IL-6 infiltration inflammatory cell involved JAK/STAT signaling pathway Lung function Lung inflammation Lymphocytes Magnesium isoglycyrrhizinate mechanism MUC5AC neutrophil Patient propionate pulmonary disease receptor reduced salmeterol xinafoate secretion serum steroidal anti-inflammatory drugs suggested TNF-α Treatment White blood cells [DOI] 10.1038/s41598-022-16775-2 [Article Type] Research
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article
Spatial region-resolved proteome map reveals mechanism of COVID-19-associated heart injury공간 영역 분석 프로테옴 지도는 COVID-19 관련 심장 손상의 메커니즘을 보여줍니다Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Acute cardiac injury acute respiratory syndrome affected Anatomy cardiovascular disease Characteristics Clinical treatment coronavirus coronavirus disease COVID-19 CP: Cell biology CP: Molecular biology Direct dysfunction heart Heart injury histological Inflammation inflammatory cell inflammatory storm Injury knowledge mechanism molecular myocardia Myocardial myocardial and microvessel injury patients with COVID-19 proteome proteomics Quantitative regions reveal SARS-CoV-2 susceptible Treatment Vascular injury virus infection with COVID-19 [DOI] 10.1016/j.celrep.2022.110955 PMC 바로가기 [Article Type] Article
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021) Reviews Published on 2022-06-092022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] addition Cancer catalytic Chimera Clinical treatment Compound Degradation disease Diseases immune disorders increase in induce introduced knockdown molecular neurodegenerative problem Protein rapid increase reported Research researcher small molecule target target protein unique viral infections [DOI] 10.1038/s41392-022-00999-9 [Article Type] Reviews
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19Research article Published on 2022-06-012022-10-05 Journal: Medical Hypotheses [Category] 변종, 유전자 메커니즘, [키워드] AGMO approach Clinical treatment deficiencies deficiency exhibited Ferroptosis GCH1 GCH1 mutations GTP heterozygous homozygous mutation hyperinflammatory state impair Inflammatory initial innate immune system involved less manuscript Marginal Marginally deficient BH4 metabolic processe Mutation nitric oxide organ systems organs oxidative stress Oxide PASC Post-acute sequelae of COVID-19 (PASC) resulting SARS-CoV-2 symptomatic Synthase tetrahydrobiopterin the patient Treatment Uncoupling iNOS [DOI] 10.1016/j.mehy.2022.110842 [Article Type] Research article
Exclusion of Reproductive-Aged Women in COVID-19 Vaccination and Clinical TrialsResearch article Published on 2022-06-012022-10-05 Journal: Women's Health Issues [Category] COVID19(2023년), SARS, 신약개발, 임상, [키워드] Analysis analyzed association Breastfeeding childbearing potential clinical Clinical treatment clinical trial clinical trials Contraception coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine database excluded exclusion exclusion criteria global pandemic individual individuals lactating lactation library male Medicine participant Pregnancy pregnant profiles required Result Sponsor study participation Treatment treatment trials trials Vaccine [DOI] 10.1016/j.whi.2022.06.004 [Article Type] Research article