Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in Spike진화하는 SARS-CoV-2 계통에 걸친 펩티도돔 감시, 스파이크에서 T 세포 에피토프 손실 가능성이 가장 큰 변이체 중 뉴클레오캡시드에서 HLA 결합 보존 밝혀Article Published on 2022-06-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Analysis Antigen B.1.1.529 binding candidate caused CD4+ T cell CD4+ T cells CD8+ comprehensive analysis concern conservation conserved Course COVID-19 disease dominant elicit epitope Epitopes Evidence Genome GISAID heterogeneity HLA immune response immune responses instance interest lineages Loss MOST Mutation N protein N proteins NCBI NIH nucleocapsid omicron pandemic peptide peptides performed Potential predicted Protein protein sequence provided Region remained S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 lineage spike sustained T cells T-cell the N protein the S protein unique vaccination variant variants viral evolution viral variant Viral variants VoC VOCs Volume [DOI] 10.3389/fimmu.2022.918928 PMC 바로가기 [Article Type] Article
Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination자연 SARS-CoV-2 감염 및 Gam-COVID-Vac 백신 접종 후 시험관 내 재활성화된 기억 B 세포의 기능 프로파일링Article Published on 2022-06-212022-09-11 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adenovirus antibody antibody-secreting cells B-cell response circulating comprehensive analysis convalescent patient Convalescent patients COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients demonstrated elicit frequencies Frequency Gam-COVID-Vac Gam-COVID-Vac vaccine healthcare humoral Humoral immunity immune response immune responses Immunity individual Infection MBC MBCs memory B memory B cell memory B cells natural natural immunity Neutralizing Neutralizing antibodies outperform performed platform Profiling Receptor binding domain recipients robust SARS-CoV-2 SARS-COV-2 infection Serum level serum levels side significantly higher Sputnik V vaccine vaccination variants of SARS-CoV-2 Viral viral antigens virus-neutralizing virus-neutralizing antibodies [DOI] 10.3390/cells11131991 PMC 바로가기 [Article Type] Article
Investigation of target sequencing of SARS-CoV-2 and immunogenic GWAS profiling in host cells of COVID-19 in Vietnam베트남 코로나19 숙주 세포에서 SARS-CoV-2 표적 염기서열 분석 및 면역원성 GWAS 프로파일링Article Published on 2022-06-192022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] affected AUC Biomarker clade clinical outcomes comprehensive analysis coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity COVID-19 treatment dataset delta variant Disease progression downstream analysis Elastic forest framework global pandemic GWAS Health Healthcare system Healthcare systems high accuracy Hospitalization host cell host cells immune response immune responses immunogenic Impact investigated investigation Predictive Predictive model prevalent Previous studies previous study progression Protein provided PRS Random forest Research risk risk score SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Sequencing severity severity of COVID-19 SNP SVM the disease therapeutic target therapeutic targets Treatment Vietnam virus virus variant virus variants [DOI] 10.1186/s12879-022-07415-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron Variants Reduce Antibody Neutralization and Acquire Usage of Mouse ACE2SARS-CoV-2 오미크론 변이체, 항체 중화 감소 및 마우스 ACE2 사용 획득Article Published on 2022-06-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 orthologues Alpha antibodies antibody Antibody neutralization antigenic antigenic shifts approved Beta binding body weight breadth comprehensive analysis conducted conserved controls convalescent plasma Delta epitope escape followed by Gamma Host host range Infection Infectious virus infectious viruses initial injection intraperitoneal injection Lineage Lung pathology Lungs magnitude majority manifested mouse Mutation neutralization omicron Omicron variant Omicron variants pandemic plasma plasma neutralization. prophylactic treatment raised reduced reduction Regulatory Authorities regulatory authority S309 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection (COVID-19) SARS-CoV-2 patient SARS-CoV-2 patients Spike protein survived the spike protein therapeutic therapeutic antibodies therapy undetectable Usage Vaccine variant variants viruses while wildlife [DOI] 10.3389/fimmu.2022.854952 PMC 바로가기 [Article Type] Article
mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273청소년의 mRNA 또는 ChAd0x1 COVID-19 예방 접종은 mRNA-1273에 이어 오미크론을 계속 인식하여 강력한 항체 및 세포 반응을 유도합니다Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adolescent antibody antibody level antibody levels Antibody Response BNT162b2 CD4+ T-cell Cell cellular response Cellular responses ChAdOx1 comprehensive analysis COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cytokine develop dominant Donor doses dual elicit Evidence generate health condition High-risk patients IL-10 immune response immune responses immunogenic Infection measure memory Mild mRNA mRNA vaccination mRNA vaccine mRNA-1273 natural infection neuro-disabilities neutralisation titre Neutralisation titres omicron Omicron variant paediatric physical populations reactivity Recognition remained response risk robust severe disease significantly increased single vaccination Strong T-cell T-cell Response T-cell responses T-cells These data vaccination Vaccine vaccine dose variant [DOI] 10.3389/fimmu.2022.882515 PMC 바로가기 [Article Type] Article
Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive OverviewSARS-CoV-2 감염 환자의 조절되지 않은 면역 반응: 종합 개요Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus adaptive alteration Antigen antigen-presenting cell antiviral immune responses B cell subset Biomarker caused CD8+ CD8+ T cell cellular cellular immunity complications of COVID-19 Comprehensive comprehensive analysis coronavirus country COVID-19 COVID-19 patients disease effective evade follicular follicular Th cell help Host Human humoral Humoral immunity identify immune responses Immunity IMPROVE Infection Inflammatory information innate and adaptive immunity involved knowledge mechanism molecular mechanism monocyte new virus outcomes pathological change pathological changes Phenotypes Post-COVID-19 syndrome predict recognize Research response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Symptom syndrome T cell Th cell Th cell subsets Th17 the SARS-CoV-2 variety [DOI] 10.3390/v14051082 PMC 바로가기 [Article Type] Review
Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identifies Critical Biomarkers of COVID-19우한의 여러 단계에 있는 환자의 혈청 대사체학 특성 분석으로 COVID-19의 중요한 바이오마커 식별Article Published on 2022-05-022022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alpha-methylstyrene Biomarker Biomarkers caused characterization chavicol clinical disease clinical measurement clinical measurements comprehensive analysis coronavirus Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical death degranulation differentially expressed example feature identification immune responses information Intervention involved knowledge lead metabolism metabolite metabolites metabolomic metabolomic analysis metabolomics Pathogenesis pathway Patient patients performed phosphate physiological Platelet potential therapeutic agent potential therapeutic agents predicted propylparaben rehabilitation patient respiratory SARS-CoV-2 sera serum severe acute respiratory syndrome Coronavirus Spread Stage stages therapeutic agents therapeutic target therapeutic targets triethanolamine uninfected Wuhan [DOI] 10.3389/fcimb.2022.882661 PMC 바로가기 [Article Type] Article
High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escapeMHC II 펩티드 제시 능력의 고해상도 프로파일링으로 SARS-CoV-2 CD4 T 세포 표적 및 면역 탈출 메커니즘 밝혀Article Published on 2022-04-292022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alleles alteration arising CD4 comprehensive analysis effective response epitope High-resolution HLA class II HLA class II alleles Immune escape immune evasion in silico in viral limitation mammalian mass spectroscopy mechanism MHC MHC allele MHC alleles MHC class MHC class II MHC II MHC II alleles Mutation peptide peptides physiological function physiological functions platform Precision provide reduced reveal SARS-CoV-2 SARS-CoV-2 peptide sensitivity silico predictions strain T cell T cells target therapeutic use threat Threats throughput understanding viral strains [DOI] 10.1126/sciadv.abl5394 PMC 바로가기 [Article Type] Article
Drug repositioning: Progress and challenges in drug discovery for various diseases약물 재배치 : 다양한 질병에 대한 약물 발견의 진보 및 도전Review Published on 2022-04-152022-08-31 Journal: European journal of medicinal chemistry [Category] 신약개발, [키워드] addition antimicrobial Antiviral benefit Cancer candidate Candidates Clinical efficacy Combination comprehensive analysis COVID-19 pandemic de novo different disease different diseases disease Diseases drug Drug discovery drug repositioning Effect Efficiency Follow-up indication indications mechanism mechanism of action Neurological diseases other diseases Progress public health emergency Research synergistic synergistic effect [DOI] 10.1016/j.ejmech.2022.114239 PMC 바로가기 [Article Type] Review
Using an Unsupervised Clustering Model to Detect the Early Spread of SARS-CoV-2 Worldwide비지도 클러스터링 모델을 사용하여 전 세계적으로 SARS-CoV-2의 조기 확산 감지Article Published on 2022-04-072022-09-11 Journal: Genes [Category] COVID19(2023년), SARS, 치료기술, [키워드] Algorithm Analysis approach can be used Cluster Clustering Comprehensive comprehensive analysis Critical deep learning deep learning clustering dissemination distributions effective Evolution Factor Features Genetic Genome geographical distribution Human migration indicated landscape Local Machine learning algorithms management Migration Model nucleotide nucleotide substitutions Population structure proportion proportions provide public health reduce risk SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes Single nucleotide polymorphism single nucleotide polymorphisms Structure subtype Taking virus [DOI] 10.3390/genes13040648 PMC 바로가기 [Article Type] Article