Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike설계된 이황화물은 잠긴 SARS-CoV-2 스파이크의 구조적 역학을 보여줍니다Article Published on 2022-07-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] Acidic Alter Analysis cellular compartment change changes in conformation conformational change conformations D614G D614G mutation Disulfide disulfide bond domain extracellular space functional high-resolution structure hinge interact modulate Mutation Neutral pre-fusion Protein provide RBD Receptor binding domain Regulation reveal SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spikes sequence Structure structures transition variants of concern viral fitness virion virus wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1010583 PMC 바로가기 [Article Type] Article
An Electrostatically-steered Conformational Selection Mechanism Promotes SARS-CoV-2 Spike Protein Variation정전기로 조종되는 구조적 선택 메커니즘은 SARS-CoV-2 스파이크 단백질 변이를 촉진합니다Article Published on 2022-07-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 amino acids Analysis analyzed collected conformational conformational change conformational changes COVID-19 COVID-19 pandemic Critical Cross-species transmission epidemiological epidemiological surveillance Evolution fusion global public health global public health emergency HADDOCK heterogeneity host cell host cell receptor hydrophobicity identify immune evasion IMPROVE local interaction local interactions MOST outbreak promote Protein protein–protein interactions Recognition recorded reducing Region replacing risk S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Selection sequence variation spike Substitution substitutions Surveillance the S protein trimer vaccination Vaccine development variant [DOI] 10.1016/j.jmb.2022.167637 PMC 바로가기 [Article Type] Article
The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD) recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while [DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article
Inhibitor induced conformational changes in SARS-COV-2 papain-like protease억제제는 SARS-COV-2 파파인 유사 프로테아제에서 구조적 변화를 유도했습니다.Article Published on 2022-07-082022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] Accessibility Analysis complexes conformation conformational change conformational changes contribute crystal structures expand IMPROVE inhibitor inhibitors Interaction interactions Ligand ligands molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations myriad Papain Papain-like protease PCA protease reported SARS-CoV-2 trajectory [DOI] 10.1038/s41598-022-15181-y PMC 바로가기 [Article Type] Article
In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of Nigella sativa and Pimpinella anisum as Potential Inhibitors of 3CL Protease of SARS-CoV-2SARS-CoV-2의 3CL 프로테아제의 잠재적 억제제로서 Nigella sativa 및 Pimpinella anisum의 종자 추출물을 포함하는 산화아연 기반 나노구조 오일 운반체에 대한 실리코 연구Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applicability candidate carrier characterized clinical trials Compound compounds conformational change coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 docking explained Extract Health histogram imperative inhibitor investigated Ligand ligands MD simulation mixture molecular molecular docking molecular docking studies molecular dynamic simulation molecular dynamics Molecular dynamics simulation MPro nanostructure Nigella Nigella Sativa Oil oleuropein Oxide pandemic Pimpenella anisum Potential protease Protein Research RMSD RMSF SARS-CoV-2 SARS-CoV-2 main protease seed selected stability structural proteins the SARS-CoV-2 trajectory Vaccines variant Zinc zinc oxide zinc oxide nanoparticles [DOI] 10.3390/molecules27134301 PMC 바로가기 [Article Type] Article
Probing structural basis for enhanced binding of SARS-CoV-2 P.1 variant spike protein with the human ACE2 receptorSARS-CoV-2 P.1 변이체 스파이크 단백질과 인간 ACE2 수용체의 향상된 결합을 위한 구조적 기초 조사Article Published on 2022-07-012022-09-11 Journal: Journal of cellular biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Analysis angiotensin angiotensin converting enzyme approach binding circulating commonality Comparative analysis complex conformational change Contact coronavirus COVID-19 cumulative cumulative effect demonstrated enzyme host receptor human ACE2 receptor Infection initial Interaction investigated molecular molecular dynamic simulation Mutation P.1 variant P.1 variants Probing Protein protein network analysis provide RBD RBD residue RBD residues RBD-ACE2 receptor Receptor binding domain reported responsible S1 domain SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein the RBD the spike protein unique variant variants virus transmission wild type [DOI] 10.1002/jcb.30276 PMC 바로가기 [Article Type] Article
Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable EpitopesSARS-CoV-2 스파이크 단백질의 구조 역학: SARS-CoV-2 변이체(알파에서 오미크론까지)의 2년 후향적 분석을 통해 보존된 에피토프와 가변 에피토프 간의 초기 차이가 드러났습니다.Article Published on 2022-06-152022-09-11 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 binding ADE analyzed antibodies antibody Antibody-dependent enhancement antiviral strategy approaches bind binding circulating conformational change conserved COVID-19 infection D614G D614G mutation Delta determined by Divergence domain Dynamics epitope Epitopes Evolution facilitate facilitating antibodies flat help host cells linear mimicking molecular Molecular epidemiology Mutation N-terminal domain Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron pandemic Retrospective analysis risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 strains SARS-CoV-2 variants selected spike Spike protein the SARS-CoV-2 the spike protein Vaccine Variability variable was determined [DOI] 10.3390/molecules27123851 PMC 바로가기 [Article Type] Article
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope35B5 항체는 보존된 스파이크 에피토프를 통해 N-글리칸 스위치를 방해하여 SARS-CoV-2 Omicron을 강력하게 중화합니다.Article Published on 2022-06-082022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 35B5 ACE2 antibody antigenic antigenic shift change changes conformational change conserved Control cryo Cryo-electron microscopy disrupting dissociation domain Efficacy electron microscopy entry receptor epitope exhibit Extracellular Fab glycan Host immune evasion Microscopy monoclonal monoclonal antibody Mutation N-terminal domain neutralization neutralize Neutralizing Neutralizing antibodies neutralizing capacity not affect NTD omicron other variant other variants RBD Receptor-binding domain Recognition SARS-CoV-2 Spike protein Structure the RBD the spike protein therapeutic transition trimer trimeric variant [DOI] 10.1016/j.chom.2022.03.035 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Delta variant isolates from vaccinated individualsSARS-CoV-2 Delta 변이체는 예방접종을 받은 개인에서 분리됩니다.Article Published on 2022-06-042022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 변종, [키워드] addition Affect circulating Cluster collected conformational change COVID-19 cytosolic Delta Delta B.1.617.2 delta variant Disruption genetic diversity Genome sequencing Genomic analysis hydrophobic immune evasion induce isolate isolates Lineage Mutation mutations Non-synonymous mutation Nsp15 Nsps ORF1 ORF1b ORF7a ORF8 Oxford Nanopore MinION polar position positive sample predominant premature stop codon Protein SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 virus SARS-CoV-2 viruses side chain Spike protein the spike protein transmembrane protein Transmissibility Transport vaccinated individual vaccinated individuals Vaccine variant variant of concern virus was performed Whole genome sequencing [DOI] 10.1186/s12864-022-08652-z PMC 바로가기 [Article Type] Article
Potential of antiviral peptide-based SARS-CoV-2 inactivators to combat COVID-19COVID-19 퇴치를 위한 항바이러스 펩티드 기반 SARS-CoV-2 불활성화제의 가능성Article Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral drug antiviral drugs antiviral therapeutics appearance binding binding energy can be used Candidates caused Cell cells complexes conformational change conformational changes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 effective Effectiveness enzyme evidenced experiment geometric host cells host receptor hydrogen Hydrogen bond hydrogen bonds hydrophobic hydrophobic interactions identify inactivation increase in induce infecting Infectious disease lack membrane fusion molecular molecular dynamics MOST non-toxic peptide peptide-based peptides permeability Potential Protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus solvent Spike protein stability surface area target the spike protein Therapies Treatment Vaccine variant viral cell Virtual screening virus water [DOI] 10.1371/journal.pone.0268919 PMC 바로가기 [Article Type] Article