Immunogenic SARS-CoV-2 S and N Protein Peptide and Cytokine Combinations as Biomarkers for Early Prediction of Fatal COVID-19치명적인 COVID-19의 조기 예측을 위한 바이오마커로서의 면역원성 SARS-CoV-2 S 및 N 단백질 펩티드 및 사이토카인 조합Article Published on 2022-03-212022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, 치료법, [키워드] Activation analyzed Biomarker Biomarkers chemokines clinical outcomes convalescent COVID-19 patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sera cytokine Cytokine activation Cytokines demonstrated difference fatal fatal COVID-19 fatality higher risk highest humoral immune response IgG IgM IgM antibody improve clinical outcomes indication knowledge likelihood longitudinal analysis marker N protein nucleocapsid Nucleocapsid phosphoprotein Patient peptide peptides prediction pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines quantified reactivity risk S protein SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S selected serum serum sample serum samples severe coronavirus disease Surface glycoprotein Treatment [DOI] 10.3389/fimmu.2022.830715 PMC 바로가기 [Article Type] Article
Inhibitor screening using microarray identifies the high capacity of neutralizing antibodies to Spike variants in SARS-CoV-2 infection and vaccination마이크로어레이를 사용한 억제제 스크리닝은 SARS-CoV-2 감염 및 백신 접종에서 스파이크 변이체에 대한 항체를 중화하는 높은 능력을 식별합니다Article Published on 2022-02-282022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition anti-S antibody antibody antibody diversity B.1.1.7 B.1.351 B.1.617.2 Cohort convalescent COVID-19 patient convalescent COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines D614G Drug development Efficacy FIVE glass slides group help heterogeneous identify Microarray Mutation NAb titers NAbs neutralization Neutralization assay neutralize Neutralizing antibodies neutralizing antibody neutralizing effect P.1 peptide peptide microarray platform Population prevalent protective effect Protein purified reduce responsible S variant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike Screening serum spike spike-ACE2 These data utility vaccination vaccinee vaccinees variant variants were assessed wild-type [DOI] 10.7150/thno.67038 PMC 바로가기 [Article Type] Article
The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients회복기 환자에서 미량 영양소와 SARS-CoV-2 특이 항체 사이의 연관성Original Paper Published on 2022-02-212022-09-10 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Adiposity antibodies antibody antibody synthesis association biochemical changes in Clinical features Concentration convalescent COVID-19 patient convalescent patient correlated correlation COVID-19 infection evaluate evaluated female female participants greater Healthcare workers hematological parameters Humoral immunity IgG IgG antibodies IgM IgM and IgG immune response immune responses immune system Infection LDH male participant male participants Micronutrient micronutrients Pandemics Platelet positive correlation positively correlated recovered patient recovered patients required Result robustness SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG serum significant negative correlation specific IgM subject susceptibility susceptibility to infection Validity Viral viral infection Vitamin Vitamin D Zinc [DOI] 10.1007/s15010-022-01774-2 PMC 바로가기 [Article Type] Original Paper
Persistence of anti-SARS-CoV-2 IgM in convalescent COVID-19 patients회복기 COVID-19 환자에서 항 SARS-CoV-2 IgM의 지속성Comment Published on 2022-01-012022-09-12 Journal: The Journal of Infection [Category] MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 IgM convalescent COVID-19 patient [DOI] 10.1016/j.jinf.2021.11.008 PMC 바로가기 [Article Type] Comment
Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection감염 후 1년에 회복 중인 COVID-19 환자의 SARS-CoV-2에 대한 면역학적 기억Article Published on 2021-12-012022-09-12 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome anti-receptor-binding domain antibody CD4 CD4(+) T-cell responses Cell cellular response convalescent COVID-19 patient convalescent patient Convalescent patients coronavirus coronavirus disease correlation COVID-19 Critical CTLA-4 cytokine dysfunction evaluate follow-up time groups humoral immune immune memory Immunologic memory increased expression marker moderate multifunctional NAb Neutralizing antibodies neutralizing antibody observé positive rate positively correlated Postinfection Prevalence produced proportion protective immunity reached recruited Reinfection SARS-CoV-2 SARS-CoV-2-specific T cell severity statistical statistical significance Support T cell T-cell TIGIT understanding vaccination were assessed with COVID-19 [DOI] 10.1016/j.jaci.2021.09.008 PMC 바로가기 [Article Type] Article
Clinical and immunological characteristics in COVID-19 convalescent patientsCOVID-19 회복기 환자의 임상 및 면역학적 특성Article Published on 2021-12-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 진단, 치료기술, [키워드] acute phase CD4 Cell cellular cellular immunity clinical convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient COVID-19 COVID-19 convalescent patient COVID-19 patient detectable ELISpot testing help humoral humoral and cellular immunity Humoral immunity IFN-γ IFN-γ ELISPOT Immune status immunological characteristics Infection information involved Lymphocytes memory Neutralization assay Neutralizing antibodies non-severe patients Pathogenesis SARS-CoV-2 SARS-COV-2 infection severity significantly higher T cells T lymphocyte the disease vaccine immunity virus-specific T cells [DOI] 10.1007/s10096-021-04360-w PMC 바로가기 [Article Type] Article
Post-Covid-19 Hemostatic Characteristics of Convalescent Patients: The Bergamo ExperienceConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 바이오마커, [키워드] Activation affected age anti-N IgG anti-S anti-S IgG anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody Response association Bergamo Biomarker Biomarkers candidate clinical symptom Coagulation Coagulopathy complement convalescent COVID-19 patient convalescent COVID-19 patients convalescent plasma COVID-19 COVID-19 patient D-dimer demographic characteristics different time point disease endothelial Endothelial dysfunction Endothelium Enrollment evaluate excessive inflammatory response experience explain fibrinogen Gender hemostasis activation Hemostatic Hospitalized hypercoagulable increased risk independent predictor Infection Inflammation involved large cohort Level marker mechanism median no correlation Patient patients plasma positively correlated predict predicted predictor Protein protein S recruitment reported Sample SARS-COV-2 infection severe COVID-19 severe disease severity significantly higher subsequent Symptoms tested thrombosis treated von Willebrand factor were measured [DOI] 10.1182/blood-2021-153611 [Article Type] Conference abstract
Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and HypothesisObservational Study Published on 2021-11-212022-10-04 Journal: Viruses [Category] MERS, 임상, 치료기술, [키워드] analyzed caused controls convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Course COVID-19 COVID-19 infection COVID-19 pandemic Critical disease cross-sectional damage Degradation demonstrated disease disease course Disease progression elevated Endothelial cell endothelial damage Evidence glycocalyx healthy controls healthy individual Hospitalization hospitalized COVID-19 patient hospitalized patient hyperinflammation indication infected with SARS-CoV-2 Injury long-COVID-19 lung damage median Mild multicenter multicenter study no difference parameter persistent progression Prospective SARS CoV-2 SARS-CoV-2 significantly symptom onset Syndecan-1 virus with mild disease [DOI] 10.3390/v13112324 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2-reactive T-cell receptors isolated from convalescent COVID-19 patients confer potent T-cell effector function회복기 COVID-19 환자에서 분리된 SARS-CoV-2 반응성 T 세포 수용체는 강력한 T 세포 효과기 기능을 부여합니다Article Published on 2021-11-012022-09-11 Journal: European Journal of Immunology [Category] SARS, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 approach B cell B cells CD4 CD8 Characteristics clone contribute convalescent convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 cytotoxicity described detectable disease-causing EC50 values ectopic effective example functional generate help HLA-A HLA-A*02:01 IFN-γ immune response Immunity in vitro initial involved long-lasting memory response Neutralizing antibodies Population reporter retrieved robust SARS-CoV-2 Sequencing Signaling single-cell single-cell sequencing T cell T cells T-cell T-cell immunity T-cell receptor TCR TCRs virus while [DOI] 10.1002/eji.202149290 PMC 바로가기 [Article Type] Article
Long Term Immune Response Produced by the SputnikV Vaccine스푸트니크 V 백신에 의해 생성된 장기 면역 반응Article Published on 2021-10-182022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation analyzed antibody breadth cellular immune responses cellular immunity circulating variant circulating variants conserved conserved regions convalescent COVID-19 patient convalescent sera convalescent serum cytokine Cytokines domain evidenced first dose fusion fusion protein high potency HRs humoral humoral immune response immune responses immunized immunogenic induce location Long mechanism Microbiology N-terminal N-terminal domain NTD overlapping peptide peptides RBD reactivity Receptor binding domain Region Repeat response S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein serum shown Spike protein SputnikV T cells term the SARS-CoV-2 the vaccine vaccinated individual Vaccine [DOI] 10.3390/ijms222011211 PMC 바로가기 [Article Type] Article