The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs다양한 SARS-CoV-2 변종 RBD 간의 교차 보호 면역 환경Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibody Antigen antigens Beta COVID-19 vaccine design cross-neutralization cross-neutralizing cross-protective cross-protective immunity Delta effective evaluated expressed IgG antibodies immune protection immunize Lambda landscape mice neutralization neutralization antibodies Neutralizing activity new SARS-CoV-2 omicron pentavalent pseudovirus pseudoviruses RBD RBD antigen RBD protein SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants the epidemic These data titers of IgG Vaccine vaccine strain Vaccines variant variants wild type [DOI] 10.3389/fimmu.2022.898520 PMC 바로가기 [Article Type] Article
Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variantsDelta 및 Omicron 변이체에 대한 COVID-19 백신 반응 및 3차 추가접종량 유도 중화항체의 비교 분석Article Published on 2022-05-052022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Adenovirus adenovirus vector vaccine anti-SARS-CoV-2 antibody antibody levels BNT162b2 booster ChAdOx1 Combination Comparative analysis COVID-19 COVID-19 vaccine cross-protective Delta delta variant dose Dosing Europe fold Health care Health care worker health care workers increase indicate induce janssen mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 booster Neutralizing antibodies neutralizing antibody of BNT162b2 omicron optimization regime response second dose variant variants [DOI] 10.1038/s41467-022-30162-5 PMC 바로가기 [Article Type] Article
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article
Neutralizing antibodies to SARS-CoV-2 Omicron variant after third mRNA vaccination in health care workers and elderly subjects의료 종사자 및 노인 대상에서 세 번째 mRNA 백신 접종 후 SARS-CoV-2 Omicron 변이체에 대한 중화 항체Article Published on 2022-05-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] administration age antibody Antibody responses B.1.1.529 Beta booster booster vaccination Breakthrough infection breakthrough infections collected Concentration Coronavirus disease 2019 COVID-19 cross-protective cross-reactive Delta detectable dose expected HCW HCWs Health care Health care worker health care workers IgG IgG antibody mRNA vaccination mRNA vaccine Mutation NAb NAb titer NAb titers NAbs neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody nursing home omicron Postinfection raised reduced remained SARS-CoV-2 severe COVID-19 significantly Spike protein subject subjects subsequent the antibody response the spike protein vaccination vaccine dose variant variants variants of concern WT virus [DOI] 10.1002/eji.202149785 PMC 바로가기 [Article Type] Article
Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology ApproachMERS, SARS-CoV 및 SARS-CoV-2에 대한 계산적으로 설계된 mRNA 및 펩티드 기반 예방 백신의 잠재적 면역원 활성: 역백신학 접근Article Published on 2022-04-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure activity acute respiratory syndrome coronavirus antiviral therapeutics B-cells binding coronavirus Coronavirus-2 Coronaviruses cross-protective CTL CTLs cytotoxic cytotoxic T lymphocytes develop effective Efficacy epitope Epitope-based vaccine Epitopes evaluated followed by HCoVs helper highly pathogenic HTL epitope HTL epitopes HTLs human coronavirus human coronaviruses humans Immune simulation immunogenic immunogenic activity imperative lethality MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular docking mRNA mRNA-based offer pandemic pathogenic coronaviruses peptide Potential predicted processed Prophylactic prophylactic vaccine. proteomic RBDs receptor-binding domains respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 similarity the receptor-binding domain these viruses TLR4 Vaccine Vaccine design viruses [DOI] 10.3390/molecules27072375 PMC 바로가기 [Article Type] Article
Development of Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccines with Broad Neutralization against SARS-CoV-2 Delta and Other VariantsSARS-CoV-2 Delta 및 기타 변이체에 대한 광범위한 중화를 갖는 수용체 결합 도메인(RBD)-접합 나노입자 백신의 개발Article Published on 2022-04-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] B.1.617.2 Beta Breakthrough infection breakthrough infections cross-protective Delta delta variant Delta variants develop development dominant hACE2 Incubation period induce Infection mice NAb NAbs nanoparticle nanoparticle vaccines. Neutralizing antibodies neutralizing antibody notable omicron Omicron variant Other PROTECT Receptor binding domain recipients rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 variant SARS-CoV-2 variants significantly strain Strains Transmission trivalent Vaccine Vaccines variant Viral Viral load VoC [DOI] 10.1002/advs.202105378 PMC 바로가기 [Article Type] Article
DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice엔벨로프 및 막 단백질을 발현하는 DNA 백신은 생쥐에서 SARS-CoV-2에 대한 부분적 보호를 제공합니다Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Against caused cellular Cellular immune response cellular response conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-protective DNA DNA vaccine dose effective Electroporation elicited envelope envelope protein Epitopes humoral Humoral immunity Humoral response immune responses immunisation International Intramuscular injection lung tissue membrane membrane protein mice pandemic Partial protection Protein provided public health emergency respiratory robust SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus Significant structural protein structural proteins T-cell epitope target titre Vaccination strategies Vaccination strategy Vaccine vaccine candidate vaccine candidates Vaccines virus [DOI] 10.3389/fimmu.2022.827605 PMC 바로가기 [Article Type] Article
A Simplified SARS-CoV-2 Mouse Model Demonstrates Protection by an Oral Replicon-Based mRNA Vaccine단순화된 SARS-CoV-2 마우스 모델은 경구 레플리콘 기반 mRNA 백신에 의한 보호를 보여줍니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition Adenovirus angiotensin anti-SARS-CoV-2 carried characteristic cross-protective determine domain drug epitope Epitopes expressing expression forest gene delivery glycoprotein hACE2 heptad repeat human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunized mice immunohistochemistry in vitro in vivo Infectious disease Infectious diseases interstitial pneumonia lab lung Lung disease Lung pathology Lungs Macrophage macrophages membrane membrane glycoprotein mice Model moderate Molecular biology mouse mouse model mRNA mRNA expression mRNA vaccine murine Neutralizing antibodies neutralizing antibody nine nsp13 oral parental peptide peptides protection purification qPCR RBD Receptor binding domain recorded RT-PCR Salmonella SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mouse model Support supported target the SARS-CoV-2 therapy transduced transducing transduction utility Vaccine Vaccine design Vaccines variant Viral viral replication virus was determined weight loss were assessed [DOI] 10.3389/fimmu.2022.811802 PMC 바로가기 [Article Type] Immunology
Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques히말라야 원숭이에서 SARS-CoV-2 감염 후 면역 및 질병 매개변수에 대한 에어로졸 전달 BCG 백신의 영향Immunology Published on 2022-02-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] Activation acute respiratory syndrome adaptive aerosol Aerosol BCG vaccination antibody Antibody-mediated immunity antiviral immune response applied bacille Calmette-Guérin BAL BCG BCG vaccination Bronchoalveolar lavage cell-mediated immune response cellular challenge chemokine Classical CD14+ monocyte Classical CD14+ monocytes clearance collected comparable Concentration contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 disease severity cross-protection cross-protective cross-reactive cytokine disease disease pathology disease severity early disease ENhance exceeded groups Heterologous High dose Histopathology Humoral immunity hypothesised immune cells immune mechanism immune response immune responses immune signature Immunity immunological parameters indicated induce Infection influence initial innate immune innate immune cell Innate immune cells Innate immunity Intervention intrabronchial intranasal macaque macaques marker mechanism Monocytes nasal nasal and pharyngeal swabs natural infection non-specific Occurrence parameter pharyngeal populations primary site priming quantified reduce respiratory respiratory pathogen rhesus macaque rhesus macaques SARS-CoV-2 secretion severe acute respiratory syndrome Coronavirus subsequent susceptible swabs T-cell T-cells the disease tissue tissue sample titre titres trained immunity Tuberculosis tuberculosis vaccine Vaccine Viral Viral RNA virus [DOI] 10.3389/fimmu.2021.801799 PMC 바로가기 [Article Type] Immunology
Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant VirusesArticle Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis anti-viral antibody approach B-cell epitope B.1.1.7 B.1.351 Beta collected contribute COVID-19 COVID-19 vaccine cross-protective diagnostic Efficacy epitope epitope mapping examined Frequency Genetic variant host cell humoral Identified immune immunodominant immunogenic immunological Immunotherapy implication in vitro experiment Infection K18-hACE2 linear epitope linear epitopes mice neutralization tests SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 strain SARS-CoV-2 variants serum sample serum samples spike Spike protein targets the SARS-CoV-2 the spike protein transgenic viral entry virus variant [DOI] 10.3390/vaccines10020251 PMC 바로가기 [Article Type] Article