COVID-19 article altimg-small=jaipcovid_s.svg altimg=jaipcovid_o.svg>Chronic Rhinosinusitis and COVID-19Research article Published on 2022-06-012022-10-05 Journal: The journal of allergy and clinical immunology. In [Category] 진단, [키워드] acute respiratory syndrome airway angiotensin converting enzyme 2 biologics cause chronic chronic inflammatory disease Chronic rhinosinusitis coronavirus Corticosteroids COVID-19 COVID-19 pandemic CRS Diagnosis Effect Efficacy and safety General population Hypothesis Infection Inflammation Inflammation endotypes information involved Loss of Smell mechanism nasal olfactory olfactory dysfunction olfactory training pathophysiologic phenotype Protective raised rhinosinusitis SARS-CoV-2 Symptoms Telemedicine therapeutic option [DOI] 10.1016/j.jaip.2022.03.003 [Article Type] Research article
COVID-19 infection: an overview on cytokine storm and related interventionsCOVID-19 감염: 사이토카인 폭풍 및 관련 중재에 대한 개요Review Published on 2022-05-262022-09-12 Journal: Virology Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory distress acute respiratory syndrome Affect ARDS ARDS patient cause caused conditions Coronavirus disease 2019 Coronavirus-2 COVID-19 Critically ill patient CRS Cytokine storm death defined Efficacy elevated Health IL-1 IL-17 IL1 IL6 impairment IMPROVE Infection Inflammatory response interleukin-6 Interleukins Intervention lung damage Patient patients with COVID-19 Pneumonia pro-inflammatory pro-inflammatory cytokines respiratory epithelium respiratory tract SARS-CoV-2 specific inhibitor specific treatment survival rate syndrome systemically TNF-α triggered tumor necrosis factor-alpha virus [DOI] 10.1186/s12985-022-01814-1 PMC 바로가기 [Article Type] Review
Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic RhinosinusitisArticle Published on 2022-05-012023-07-07 Journal: American Journal of Rhinology & Allergy [Category] COVID19(2023년), [키워드] ACE2 CRS eosinophil epithelial ciliated cell IFN-γ IL-13 SARS-CoV-2 TMPRSS2 TNF-α type 1 immune response. [DOI] 10.1177/19458924211059639
Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortalityCOVID-19 환자의 사후 폐 조직의 분자 서명은 사망률을 이끄는 뚜렷한 궤적을 시사합니다Article Published on 2022-05-012022-09-12 Journal: Disease Models & Mechanisms [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence Activation acute respiratory syndrome Autopsy can be used CCL19 characteristic classical complement controls coronavirus COVID-19 COVID-19 patient CRS cytokine cytokine release dominant driving in silico infections Infectious disease lung lung abnormality lung damage Lung microbiome Lung pathology lung tissue majority Metatranscriptomics Microbiome molecular molecular mechanism Mortality Pasteurella pathogen Patient patients performed SARS-CoV-2 SARS-COV-2 infection secondary infections Sequencing severe COVID-19 severe COVID-19 patients Staphylococcus suffered supported syndrome therapy trajectory unfolded protein response uninfected upregulation Whole-transcriptome sequencing. [DOI] 10.1242/dmm.049572 PMC 바로가기 [Article Type] Article
Immunomodulatory effects of zinc and its impact on COVID-19 severityShort communication Published on 2022-05-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 변종, 임상, 진단, [키워드] adverse effect Anti-inflammatory antioxidant chemokines clinical study contribute correlated COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient COVID-19 severity CRS cytokine Cytokine release syndrome Cytokines deficiency Effect elevated excessive secretion Healthcare system immune system Immunity immunomodulation immunomodulatory effect Impact Intervention mitigate poor prognosis pro-inflammatory cytokine pro-inflammatory cytokines SARS-CoV-2 systemic inflammatory Zinc [DOI] 10.1016/j.amsu.2022.103638 [Article Type] Short communication
Meeting the COVID challenge: Optimizing vCD34 + in cryopreserved HPC samples for implementation of an external QA ProgramCOVID 문제 해결: 외부 QA 프로그램 구현을 위해 냉동보존된 HPC 샘플에서 vCD34 + 최적화Multicenter Study Published on 2022-04-012022-09-11 Journal: Cytotherapy [Category] 바이오마커, [키워드] Allogeneic Analysis approach CD34 Cell Combination condition COVID COVID-19 pandemic CRS cryopreserved reference sample cytometric dispatch distance distribution dry ice Enumeration evaluate exclusion External external quality assurance Flow followed by harmonization hematopoietic progenitor cell implementation interlaboratory comparison liquid nitrogen meeting multicenter multicenter study National nitrogen Pandemics platform proficiency testing Program Quality Quality assurance reproducibility specificity transplantation viability viable CD34(+) HPC enumeration. was performed [DOI] 10.1016/j.jcyt.2021.10.009 PMC 바로가기 [Article Type] Multicenter Study
The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성Article Published on 2022-03-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses [DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article
Axicabtagene ciloleucel as first-line therapy in high-risk large B-cell lymphoma: the phase 2 ZUMA-12 trial Research Published on 2022-03-212022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, [키워드] 95% CI 95% confidence interval Anti-CD19 autologous B-cell B-cell lymphoma Blood level CAR Central nervous system chimeric antigen receptor CNS Complete CRS Cytokine release syndrome Cytokines effective EFS evaluated event events Follow-up median median time multicenter neurologic nine occurred outcome Patient primary endpoint Primary outcome reached remained safety profile secondary single-arm survival T-cell therapy Treatment Trial [DOI] 10.1038/s41591-022-01731-4 [Article Type] Research
Targeting TNF-α for COVID-19: Recent Advanced and ControversiesPublic Health Published on 2022-02-112022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, COVID19(2023년), SARS, [키워드] ACE2 acute lung injury angiotensin-converting enzyme 2 association characterized coronavirus disease COVID-19 CRS Cytokine release syndrome Disease progression effective facilitate IL-10 IL-2 IL-7 Infection infliximab inhibitors Interaction MIS-C Necrosis pathophysiologic pathway pro-inflammatory cytokine recent SARS-CoV-2 severe COVID-19 patients severe SARS-CoV-2 Severity of disease targeting therapeutic strategy TNF-α inhibitor TNF-α Treatment Trigger upregulated [DOI] 10.3389/fpubh.2022.833967 PMC 바로가기 [Article Type] Public Health
Continuous Renal Replacement Therapy With oXiris Filter May Not be an Effective Resolution to Alleviate Cytokine Release Syndrome in Non-AKI Patients With Severe and Critical COVID-19Pharmacology Published on 2022-02-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Admission alanine aminotransferase ALB albumin alleviate ALT Aspartate aminotransferase AST C-reactive protein circulating cytokine clinical collected Concentration Continuous Continuous renal replacement therapy control group coronavirus disease COVID-19 Critical CRP CRRT CRS Cytokine release syndrome Cytokine storm demographic determine fibrinogen Filter hospital Hospitalization hyper inflammation ICU IFN-γ IL-10 IL-2 IL-4 IL-6 individual inflammatory chemokines intervention group IRB lymphocyte Lymphocyte count medical records medical system neutrophil no significant difference non-acute kidney injury Organ failure oXiris filter Patient Platelet proportion Protein random number table randomly divided Release renal replacement therapy replacement Resolution SARS-COV-2 infection sensitivity serum creatinine severe and critical COVID-19 severity of COVID-19 significantly significantly higher significantly lower SOFA strained TNF-α total bilirubin treated Treatment two groups WBC White blood cell [DOI] 10.3389/fphar.2022.817793 PMC 바로가기 [Article Type] Pharmacology