Modeling COVID-19 Outbreaks in Long-Term Care Facilities Using an Agent-Based Modeling and Simulation ApproachArticle Published on 2022-02-242022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, [키워드] affected Agent-based modeling Analysis average Canada Care Contact Contact matrix COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19 test death death rate deaths disease modeling effective Effectiveness facility General population Health higher risk individual infection control Infectious disease less long-term care facilities measure modeling outcomes pandemic Personal protective equipment predicted problems random reduce Research resident Seven Simulation Spread Variation [DOI] 10.3390/ijerph19052635 PMC 바로가기 [Article Type] Article
Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until NowReview Published on 2021-11-102022-10-31 Journal: Cells [Category] COVID-19, [키워드] addressed application artificial intelligence Biomedical research cardiovascular cardiovascular research Cell cell replacement therapy clinical trials Combination COVID-19 degenerative disease disease modeling Drug discovery embryonic stem cells example Genome Genomics global pandemic highlight mRNA-based vaccine Patient pluripotent stem cell pluripotent stem cells regenerative Research safety pharmacology STEM tissue translation treat vessels [DOI] 10.3390/cells10113112 PMC 바로가기 [Article Type] Review
Harness Organoid Models for Virological Studies in Animals: A Cross-Species PerspectiveMicrobiology Published on 2021-09-162022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] animal Antiviral applied Cell culture condition COVID19 Culture disease modeling domestic and wild animals Human immune imperative in vitro mimicking Model organ Organoid Research stem cell viral pathogenesis virological study virus viruses wild animals zoonosis zoonotic [DOI] 10.3389/fmicb.2021.725074 PMC 바로가기 [Article Type] Microbiology
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19성체 줄기 세포 유래 완전한 폐 오르가노이드 모델은 COVID-19에서 폐 질환을 모방합니다Tools and Resources Published on 2021-08-132022-09-12 Journal: eLife [Category] MERS, 진단, [키워드] airway airway epithelia alveolar Alveolar Type II AT2 AT2 differentiation cause Cell cells center clinical Cohort Complete component computational COVID-19 COVID-19 pathogenesis Critical Diego disease modeling distal finding Host immune response Human human lung Illumina immune response immunologist in vitro include lung Lung disease lung organoid manuscript Medicine monolayer NIH NovaSeq 6000 pneumocyte Program proximal Respiratory samples responsible SARS-CoV-2 SARS-CoV2 scientist STEM supported sustained System therapy transcriptomic Vaccines viral infection virus viruses were infected widespread [DOI] 10.7554/eLife.66417 PMC 바로가기 [Article Type] Tools and Resources
How does vulnerability to COVID-19 vary between communities in England? Developing a Small Area Vulnerability Index (SAVI)Original Research Published on 2021-08-042022-10-29 Journal: Journal of epidemiology and community health [Category] COVID-19, MERS, SARS, [키워드] age agency Analysis Area association Care Characteristics Community conditions COVID-19 COVID-19 epidemic COVID-19 mortality cross-sectional Deprivation Developing disease modeling East ecological England estimate FIVE Health inequalities hospital increase in increased risk index indicate initial long-term health condition long-term health conditions measure multivariable North pandemic performed Poisson regression model Prevalence proportion public health public health policy regions Result risk second wave the epidemic vulnerability were used West [DOI] 10.1136/jech-2020-215227 PMC 바로가기 [Article Type] Original Research
Pitfalls in Modeling Asymptomatic COVID-19 InfectionPublic Health Published on 2021-04-122022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] asymptomatic infection COVID-19 disease modeling disease transmission Epidemiology modeling [DOI] 10.3389/fpubh.2021.593176 PMC 바로가기 [Article Type] Public Health
Modeling of SARS-CoV-2 Treatment Effects for Informed Drug RepurposingPharmacology Published on 2021-03-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antiviral effect approach Artemisinin benefit candidate clinical trial Concentration coronavirus disease COVID-19 Diagnosis disease modeling dosing regimen dropped drug drug candidate Drug repurposing Effect effective explained Host host response human SARS-CoV-2 Hydroxychloroquine immune response in vitro in vitro experiment in vivo Informed Intervention Ivermectin log lung tissue modeling Pharmacometrics profile reduce Repurposed drug repurposing SARS-CoV-2 selected Treatment viral dynamics viral kinetics Viral load were given [DOI] 10.3389/fphar.2021.625678 PMC 바로가기 [Article Type] Pharmacology
Modeling the Human Body on Microfluidic ChipsReview article Published on 2021-02-102022-10-05 Journal: Trends in Biotechnology [Category] 비임상, [키워드] animal approach Body complex Culture disease disease modeling Drug discovery functional highlight homeostasis Human human disease in vitro in vitro model in vitro models limitation Microphysiological systems modeling multiple organ offer organ-on-chip pathophysiology Personalized medicine platform therapeutic tissue development toxicities translational [DOI] 10.1016/j.tibtech.2021.01.004 [Article Type] Review article
Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart FailsPerspective Published on 2020-12-102022-10-04 Journal: Stem Cell Reports [Category] MERS, SARS, 신약개발, [키워드] acute respiratory syndrome Arrhythmias can be used Cardiac pathology cardiovascular cardiovascular cells cardiovascular disease Cell coronavirus coronavirus disease COVID-19 Cytokine storm death derivative disease modeling drug Drug screening Fail feature heart hPSCs Human infect Infection mice myocardial injury outbreak pandemic pathology Perspective poor prognosis provided receptor Respiratory complications resulting SARS-CoV-2 Scientific community STEM the disease therapeutic Therapies treat Vaccine virus [DOI] 10.1016/j.stemcr.2020.11.003 PMC 바로가기 [Article Type] Perspective
Nipah virus dynamics in bats and implications for spillover to humansArticle Published on 2020-11-172023-06-22 Journal: Proceedings of the National Academy of Sciences of [Category] 조류인플루엔자, [키워드] bats disease modeling henipavirus. Nipah virus Pteropus [DOI] 10.1073/pnas.2000429117 PMC 바로가기