The capture of host cell’s resources: The role of heat shock proteins and polyamines in SARS-COV-2 (COVID-19) pathway to viral infectionReview Published on 2022-04-192023-07-08 Journal: Biomolecular concepts [Category] COVID19(2023년), [키워드] drug targets heat shock proteins human hosts polyamines SARS-CoV-2 [DOI] 10.1515/bmc-2022-0008 [Article Type] Review
Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing구조 기반 약물 설계를 사용한 SARS-CoV-2 스파이크 당단백질에 대한 선택된 천연 파이토케미컬의 항바이러스 효능Article Published on 2022-04-082022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis binding binding affinity Bioavailability candidate Compound conducted Coronaviral coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 crystal structure database disease distribution docked docked complex docked complexes drug drug candidate drug targets Effectiveness Environment excretion flavonoid Health host cells Immunological response library metabolism milk molecular molecular docking molecular dynamic simulation molecular interaction MPD3 natural pandemic PDB penetrate pharmacological target Phylloflavan phytochemical phytochemicals Protein PubChem Receptor binding domain S-RBD SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Sickness silico studies silico study spike spike glycoprotein Spike protein subgroups thistle Virtual screening virulent was obtained Zinc [DOI] 10.3390/molecules27082401 PMC 바로가기 [Article Type] Article
Drug repurposing strategies and key challenges for COVID-19 managementReview Published on 2022-04-012023-07-07 Journal: Journal of drug targeting [Category] COVID19(2023년), [키워드] clinical trials Drug repurposing drug targets pathophysiology SARS-CoV2 [DOI] 10.1080/1061186X.2021.2013852 [Article Type] Review
Machine learning based predictive model and systems-level network of host-microbe interactions in post-COVID-19 mucormycosisResearch article Published on 2022-01-012022-10-05 Journal: Microbial pathogenesis [Category] SARS, 바이오마커, 변종, 진단, [키워드] age Analysis association bioinformatics Bioinformatics analysis Biomarker Biomarkers Case report caused Characteristics COVID-19 COVID-19 patients Critical Diagnosis diagnostic disease disease course Disease model drug drug target drug targets experimental validation expression Factors fungi gastrointestinal tract Gender Host-microbe interaction network identify immune dysregulation immunocompromised individual incidence India Infection Interaction machine machine learning management mechanical ventilation microorganism morbidity Mucorales Mucormycosis non-specific opportunistic infection parameters Patient patients polyprotein Post-COVID-19 mucormycosis potential risk Predictive Prognosis prognostic Proteins replicase resulting rising Risk factors RPS6 Symptom Symptoms Systems biology text Therapeutic molecule therapy Treatment use of steroids [DOI] 10.1016/j.micpath.2021.105324 [Article Type] Research article
The Role of Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug DesignMicrobiology Published on 2021-12-242022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] alleviate Apoptosis ATF6 autophagy cause Cell complex interplay coronavirus Coronavirus infection Coronavirus replication cytoplasm drug drug target drug targets Endoplasmic reticulum endoplasmic reticulum stress ER stress homeostasis host innate immunity Human Infection innate immune response knowledge microRNA modulate occur pathogen Pathogenesis regulate Replication reported response role signaling pathways threat unfolded protein response unfolded protein response (UPR) UPR [DOI] 10.3389/fmicb.2021.808593 PMC 바로가기 [Article Type] Microbiology
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targetsReview Published on 2021-11-122023-06-14 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, [키워드] ACE, angiotensin-converting enzyme ACE2, Angiotensin-converting enzyme-2 ADAM17, A disintegrin and metalloproteinase 17 ARDS, acute respiratory distress syndrome AT1R, angiotensin II type 1 receptor COVID-19 COVID-19, Coronavirus disease 2019 drug targets ERK, Extracellular signal regulated kinase HIF-1, Hypoxia-inducible factor 1 JAK/STAT, Janus kinase/signal transducer and activator of transcription JNK, Jun N-terminal kinase MAPKs, mitogen-activated protein kinases Molecular pathway mTOR, Mammalian target of rapamycin NF-κB, nuclear factor κB NLRP3, NOD-like receptor family pyrin domain containing 3 PAMP, Pathogen-associated molecular patterns PARG, Poly (ADP-ribose) glycohydrolase PARP-1, Poly ADP-ribose polymerase-1 PRRs, Pattern Recognition Receptors RAS, Renin-angiotensin system SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TLRs, Toll-like receptors TMPRSS2, Transmembrane Protease Serine 2 TNF-α, tumor necrosis factor alpha TRPM2, Transient receptor potential melastatin type 2 [DOI] 10.1016/j.biopha.2021.112420 PMC 바로가기 [Article Type] Review
Repurposing the inhibitors of COVID-19 key proteins through molecular docking approachResearch article Published on 2021-11-012022-10-05 Journal: Process Biochemistry [Category] 신약개발, [키워드] active site acute respiratory syndrome ADME Adsorption approach Benazepril binding affinity can be used coronavirus COVID-19 distribution docking drug Drug suitability drug targets drugs targeting effective evaluate evaluated Health identify in viral inhibitor involved metabolism Moexipril molecular molecular docking MPro non-toxic potential therapeutic agent predict protease Protein RdRP Replication repurposing RNA virus RNA-dependent RNA polymerase spike glycoprotein structural proteins survival therapeutic therapeutic targets Trandolapril Treatment virus was used [DOI] 10.1016/j.procbio.2021.08.015 [Article Type] Research article
Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300Research Article Published on 2021-08-172022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome bat coronaviruses Cell chymotryptic digestion cleavage coronavirus coronavirus disease COVID-19 cysteine cysteines demonstrated dimerization drug targets ENCODE experiment gel filtration glutaredoxin glutathionylation inhibit M pro main protease Modification monomer mutant oxidative stress pathophysiology polyprotein polyproteins pp1a pp1ab protease Protein provide reactive reducing regulated Replication required responsible restored Reversible SARS-CoV-2 susceptible therapeutic interventions thioltransferase ultracentrifugation undergo viral replication [DOI] 10.1128/mBio.02094-21 PMC 바로가기 [Article Type] Research Article
Role of Multifunctional Cytoskeletal Filaments in Coronaviridae Infections: Therapeutic Opportunities for COVID-19 in a Nutshell코로나바이러스과 감염에서 다기능 세포골격 필라멘트의 역할: 간단히 말해서 COVID-19에 대한 치료 기회Review Published on 2021-07-192022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Antiviral appearance Community Coronaviridae Coronaviridae family coronavirus COVID-19 COVID-19 research CoVs Critical cytoskeleton drug target drug targets Effect effective Efficacy filament filaments Health healthcare host cell host cells humans immunological Immunomodulatory agents involved mechanism Medicine Medicines mutant name new strain Novel coronavirus nutshell opportunity other treatments outbreak Pandemics pharmacological physiological problem problems Randomized controlled trial respiratory review role SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly Spread subset subversion the Coronaviridae the disease Treatment unique Vaccine virus [DOI] 10.3390/cells10071818 PMC 바로가기 [Article Type] Review
Virtual screenings of the bioactive constituents of tea, prickly chaff, catechu, lemon, black pepper, and synthetic compounds with the main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE 2) of SARS-CoV-2Research Published on 2021-06-152022-10-31 Journal: Future Journal of Pharmaceutical Sciences [Category] COVID-19, [키워드] 1R42 ACE Analysis angiotensin-converting enzyme 2 approach binding affinity Compound COVID-19 Discovery Studio docking score drug targets enzyme Enzymes FIVE Google highest human Angiotensin-converting enzyme inhibit kaempferol Ligand ligands molecular docking Molecular docking study MPro Mutation performed Probability protease Protein Result SARS-CoV-2 scored Screening selected the binding affinity theaflavin therapy Treatment UCSF Chimera virus website [DOI] 10.1186/s43094-021-00275-7 PMC 바로가기 [Article Type] Research