Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adultsArticle Published on 2022-10-042022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Activation Adaptive immune response antibodies antibody BCG BCG vaccination benefit booster breadth CD4+ CD8+ T-cell changes changes in chromatin Combination COVID-19 vaccines Delta Effect effector memory eight elevated ENhance Epigenetic Evidence expressing greater Heterologous highlighting IL-1β IL-2 immune response Immunity in-depth analysis India marker memory T-cell response mutant NAb Neutralizing provide revaccination SARS-CoV-2 seronegative significantly higher subset T cell T-cell Response tested TNF-α TNF-α expression trained immunity Tuberculosis vaccination Vaccine vaccine-induced immune response [DOI] 10.3389/fimmu.2022.985938 PMC 바로가기
Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infectionArticle Published on 2022-10-032022-11-15 Journal: Virology Journal [Category] 치료제, [키워드] 25-hydroxyvitamin D age Analysis antiviral immune response association cholesterol control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patients determine differential expression disease downregulation enrolled Epigenetic erythrocyte sedimentation rate ESR evaluated expression level HDL healthy control high-density in both group indicated Infection LDL low-density Mild mild infection motif mRNA level multivariate logistic regression Patient patients PCR cycle polymerase chain Proteins qPCR reduction in required Severe COVID-19 Infection severe group Severe infection severe infections severity severity of COVID-19 significantly lower the mean threshold TRIM28 Tripartite Motif Tripartite motif containing 28. was used [DOI] 10.1186/s12985-022-01885-0 PMC 바로가기
Expression analysis of miRNA hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients supports its role in regulating ACE2 and DPP4 receptorsArticle Published on 2022-10-012022-11-15 Journal: Journal of Cellular and Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 Analysis control sample coronavirus disease COVID-19 COVID-19 patient COVID-19 patients differential expression downregulation DPP4 enzyme Epigenetic functional Genes hsa-let7b-5p investigated involved low expression mechanism miRNA miRNAs modulation naso-oropharyngeal swab Novel coronavirus NPs overexpressed overexpression progression receptor Regulation reported respiratory responsible SARS-CoV-2 SARS-COV-2 infection significantly statistically significant Support the disease therapeutic target transcripts [DOI] 10.1111/jcmm.17492 PMC 바로가기
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibilityResearch article Published on 2022-10-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene ACE2 protein age angiotensin-converting enzyme 2 Arterial hypertension association Asthma BMI body mass index changes in clinical variable clinical variables COVID-19 COVID-19 susceptibility described determinant disease susceptibility DNA methylation Epigenetic epigenetics evaluate evaluated expression expression profile Factor Host host cell host factors Infection involved Male sex mechanism Methylation molecular cause mRNA expression nasopharyngeal swab sample obesity overexpression Peripheral blood promoter region quantified regulated Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sex significant difference smoking study group susceptibility the disease type II diabete underlying disease Variability variable virus volunteers was determined [DOI] 10.1016/j.meegid.2022.105357 [Article Type] Research article
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccinationReview article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Affect Asymptomatic clinical manifestation coronavirus disease Coronavirus-2 COVID-19 COVID-19 pathogenesis demonstrated Effectiveness ENhance Epigenetic Genes Genetic genetic diversity Genetic variation Genome heterogeneity Host host cell Immune escape immune-related genes life-threatening Mutation outbreak provide responsible SARS-CoV-2 severity of COVID-19 shown Symptoms vaccination Vaccine variant variants virus [DOI] 10.1016/j.intimp.2022.109128 [Article Type] Review article
Impaired activation of transposable elements in SARS-CoV-2 infectionArticle Published on 2022-09-052022-11-15 Journal: EMBO Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activate activated Activation Cell cellular changes in Chromatin structure correlation COVID-19 Defense drug target element elements Epigenetic epigenetics Evidence explain expression expression level functional Genes Host host immune system identify immune Impaired Infection interferon interferon response mechanism primary cells Proteins provide regulate robust SARS-CoV-2 SARS-COV-2 infection suggested the SARS-CoV-2 Transcription transposable elements. upregulation variable viral infections Viral load viruses [DOI] 10.15252/embr.202255101 PMC 바로가기
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Activation Affect Antiviral Biomarker blood cell change changes in Cohort coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNA DNA methylation effector Epigenetic epigenetics expression expression of gene Hospitalized identify Infection intensive care unit Interaction interferon response involved lesion management Methylation MOST outcomes pathology pathophysiology pathway Patient populations Potential treatment recent reported SARS-CoV-2 SARS-COV-2 infection Severity of infection shown subset Symptom Symptoms the disease transcriptomics upper respiratory tract [DOI] 10.1016/j.biopha.2022.113396 PMC 바로가기
Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical ExposuresCOVID-19 위험과 환경 화학 물질 노출의 교차점에서의 후성 유전학Review Published on 2022-09-012022-09-11 Journal: Current environmental health reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter among others Chemical contaminant COVID-19 COVID-19 susceptibility disease disrupting Drawing Endocrine Environmental chemicals Epigenetic epigenetic modification epigenetics Evidence exposure host antiviral responses host response immune pathway immune system Immunity Immunologic memory immunomodulation implicated include Infectious disease Inflammation Intersection involved mechanism memory Modification molecular mechanism Numerous Pathways recent Recognition Regulation risk SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severity Specific susceptibility the SARS-CoV-2 virus viral entry [DOI] 10.1007/s40572-022-00353-9 PMC 바로가기 [Article Type] Review
Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approachesSARS CoV-2 감염의 후성유전학적 기전과 잠재적인 치료적 접근의 이해Review Published on 2022-09-012022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Anti-viral immune response association build caused Community coronavirus COVID-19 disease severity DNA DNA methylation drug effective eliminating Epigenetic epigenetic regulator epigenetics Escalation Health highlight histone Histone modification host cell host cells immune immune responses Immunity Infection initial Interaction mechanism microRNA Modification Mortality pandemic Pathogenesis pathogenesis of SARS-CoV-2 reduced risk SARS CoV-2 SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity subsequent the disease Therapeutic approach therapeutic intervention Therapies understanding variants of SARS-CoV-2 viral infection Virology [DOI] 10.1016/j.virusres.2022.198853 PMC 바로가기 [Article Type] Review