Functional enrichment analysis – Page 2 – Communicable Diseases Research

Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approach

SARS-CoV-2 감염을 손상/퇴치하기 위한 CK2 매개 신호 표적화: 컴퓨터 생물학 접근

Research Article

Published on 2021-12-202022-09-10
Journal: Molecular Medicine [Category] SARS, 신약개발, 유전자 메커니즘,

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic

차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀

Immunology

Published on 2021-12-152022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Acute kidney injury acute lung injury ADRB2 AhR AKI Analysis analyzed approach approaches ARDS Asthma cardiovascular disease cardiovascular diseases CASP1 caused CCL5 co-expressed co-expression co-expression network analysis coagulation disorders Combination Comorbidities Comorbidity complications COVID-19 COVID-19 pandemic COVID-19 patient cytokine Cytokine storm Diabetic diabetic complications distress Factors functional enrichment Functional enrichment analysis GDI2 gene co-expression network gene expression matrix gene networks generate Genes GzmB healthy healthy sample healthy samples HIF1a highest Host Host immune response HSP90AA1 HSPA5 HSPD1 hub genes hub-high traffic genes ICAM1 identify IFNg IL10 IL1B IL6 Immunopathogenesis information IRAK3 knowledge liver disorder Liver disorders Lung injury lymphopenia MAPK1 mechanism Mild molecular molecular mechanism molecular mechanisms mononuclear cell mononuclear cells network NFkB1 OASL Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Perturbation Potential PPI Pregnancy pregnancy complications PRF1 protein-protein interaction provide PTEN RAB5A Regulatory respiratory distress Respiratory distress syndrome Result RHOA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions signaling pathway signaling pathways SOCS1 SOCS3 Spread SUMO1 syndrome Systems biology systems immunology target Therapeutic strategies therapeutic target therapeutic targets therapeutic targets in infectious diseases thrombosis TNF TNFRSF1A TP53 Traffic transcriptional transcriptomics transfer was used were used WGCNA with COVID-19
[DOI] 10.3389/fimmu.2021.789317 PMC 바로가기 [Article Type] Immunology

New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data

다발성 골수종과 COVID-19 사이의 유전적 특성에 대한 새로운 통찰력: 유전자 발현 옴니버스 마이크로어레이와 암 게놈 아틀라스 데이터의 통합 생물정보학 분석

Comparative Study

Published on 2021-12-012022-09-11
Journal: International journal of laboratory hematology [Category] SARS, 유전자 메커니즘,

[키워드] 95% CI association bioinformatics Bioinformatics analysis Cancer Characteristics Cohort Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cox regression analysis COX6C Cytochrome C cytochrome c oxidase data set DEGs differentially expressed gene Differentially expressed genes domain downregulated expression Factor Features FIVE Functional enrichment analysis Gene Expression Genetic Genome Hematological malignancy identify independent Infection Microarray Mild mild illness Multiple Multiple myeloma New NOD2 nucleotide oligomerization overall survival Patient performed Prognosis prognostic biomarker Prognostic biomarkers protein-protein interaction screened severe COVID-19 subunit survival upregulated with COVID-19
[DOI] 10.1111/ijlh.13717 PMC 바로가기 [Article Type] Comparative Study

Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection

Research article

Published on 2021-11-012022-10-05
Journal: Computers in biology and medicine [Category] SARS, 바이오마커, 변종,

[키워드] activities acute respiratory syndrome ADORA3 analysed Analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional Functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread
[DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article

Identification of Novel COVID-19 Biomarkers by Multiple Feature Selection Strategies

다중 기능 선택 전략에 의한 새로운 COVID-19 바이오마커 식별

Research Article

Published on 2021-09-272022-09-11
Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 바이오마커,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis arising best Biomarker Classifier classifiers coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis expression profile expression profiles false negatives functional enrichment Functional enrichment analysis Genes GEO database global pandemic golden standard identification leads Multiple network analysis novel Nucleic acid detection PCA positive PPI Principal component principal component analysis protein-protein interaction respiratory SARS-CoV-2 SARS-CoV-2 nucleic acid screened Selection severe acute respiratory syndrome Coronavirus Strategy Support SVM the disease triggering was used
[DOI] 10.1155/2021/2203636 PMC 바로가기 [Article Type] Research Article

Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis

COVID-19 발병 과정에서 취약한 숙주 단백질을 식별하기 위한 SARS-CoV-2의 숙주-바이러스 상호작용 분석

Article

Published on 2021-09-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘,

[키워드] Analysis CANX CAPZB cellular centrality complex composed COVID-19 COVID-19 pathogenesis Critical disease Diseases effort functional enrichment Functional enrichment analysis Genetic Host host protein HSPA1A HSPA5 human proteins human respiratory tract identify identifying IGF2R infection mechanism interactions involved ITCH Laboratory molecular mechanism molecular mechanisms neurodegenerative Pathogenesis Pathways performed potential therapeutic targets produced Protein protein-protein interaction Proteins PSMC5 RAB5A RAB7A RAB8A RBX1 Respiratory tract diseases SARS-CoV-2 Signaling therapeutic target therapeutic targets
[DOI] 10.1016/j.meegid.2021.104921 PMC 바로가기 [Article Type] Article

Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes

기존 제2형 당뇨병과 SARS-CoV-2 감염에 대한 시너지적 복잡성의 분자적 통찰력 확인

Article

Published on 2021-09-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 치료기술,

[키워드] activities Analysis analyzed approaches association bioinformatics BIRC3 caused Cell Comorbidities Comorbidity conditions contributing to COVID-19 COVID-19 outbreak CREB3L1 cytokine cytokine receptor DEGs detect determine diabete diabetes differentially expressed gene Differentially expressed genes Disease progression drug drug candidate drug candidates Drug molecules enrichment enrichment analyses evaluated expressed Factor followed by FOSL1 Functional enrichment analysis Genetic genetic determinant genetic factors global public health Health identify identifying IL-17 IL1B Interaction IRF1 islet cell KLF11 let-7b-5p lung epithelium cell lung epithelium cells microRNA MicroRNAs miR-1 miRNA miRNAs MME molecular overlapped pancreatic pancreatic islet Pathways Patient PBMC PBMCs PPI prevalent protein-protein interaction protein–protein interactions receptor Research SARS-CoV-2 SARS-COV-2 infection severity severity of COVID-19 significant pathway significant pathways synergistic T2D TFS the disease therapeutic intervention TNF transcription factor transcription factors transcriptomic data Type type 2 diabete type 2 diabetes
[DOI] 10.1016/j.compbiomed.2021.104668 PMC 바로가기 [Article Type] Article

Comprehensive investigation of RNA-sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome

RNA 시퀀싱 데이터 세트에 대한 포괄적인 조사는 코로나바이러스 질병 2019 급성 호흡 곤란 증후군의 허브 유전자 및 분자 메커니즘을 보여줍니다

Article

Published on 2021-08-012022-09-11
Journal: IET systems biology [Category] 유전자 메커니즘,

[키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS ARDS patients CD4 Cell complement Comprehensive comprehensive analysis control group coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 ARDS patient cytokine dataset DEGs differentially expressed gene Differentially expressed genes drug eosinophil eosinophils follicular Functional enrichment analysis G-protein Glutamate GSE163426 hub genes Immune cell infiltration infiltration involved Macrophage macrophages mechanism molecular mechanism molecular mechanisms network analysis pathway patients potential molecular receptor respiratory distress Respiratory distress syndrome reveal RNA sequencing RNA-sequencing significantly syndrome T cell T cells was obtained
[DOI] 10.1049/syb2.12034 PMC 바로가기 [Article Type] Article

Interplay between SARS‐CoV‐2‐derived miRNAs, immune system, vitamin D pathway and respiratory system

SARS-CoV-2 유래 miRNA, 면역계, 비타민 D 경로 및 호흡기계 간의 상호작용

Original Article

Published on 2021-06-222022-09-10
Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] analysed Analysis bioinformatics biological processe biological processes China contributing to coronavirus death develop Disease progression Evidence expression level functional enrichment Functional enrichment analysis Genes Genome help Host identify immune pathway immune pathways immune system intensity involved many cases mature miRNA mature miRNAs mechanism Mild miRNA miRNAs molecular New coronavirus pandemic Pathogenesis pathway Pathways precursor predict predicted recognize regulatory element regulatory region Research respiratory Respiratory system RNAseq RNAseq data SARS‐CoV‐2 SARS‐COV2 target gene Target genes the disease therapeutic target Viral viral miRNAs virus virus genome virus pathogenesis Vitamin D vitamin D pathway
[DOI] 10.1111/jcmm.16694 PMC 바로가기 [Article Type] Original Article

Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019

코로나바이러스 질병 2019에서 관련 경로 및 치료 약물의 스크리닝을 위한 통합 생물정보학 분석

Article

Published on 2021-04-012022-09-11
Journal: Archives of medical research [Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] 2019-nCoV 2019-nCoV coronavirus acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis antiviral drug Antiviral effect antiviral effects approved assist bioinformatics Bioinformatics analysis caused Clinical research Clinical treatment clinically conducted contribute coronavirus Coronavirus infection COVID-19 COVID-2019 database disease drug Effects EGCG Epigallocatechin-3-gallate expression functional enrichment Functional enrichment analysis Genes hub genes human coronavirus human protein human proteins ingredient inhibit inhibitor inhibitors Integrated analysis Interaction involved mechanism MERS MERS-CoV N protein network analysis Novel coronavirus PKA Previous studies progression Protein reduce Research resveratrol SARS-CoV-2 SARS-COV-2 infection screened Screening selected significant pathways significantly Stage targets therapeutic targets trans trans-resveratrol transcriptional regulation Treatment Vaccine virus
[DOI] 10.1016/j.arcmed.2020.11.009 PMC 바로가기 [Article Type] Article