Unmethylated CpG motif-containing genomic DNA fragments of bacillus calmette-guerin improves immune response towards a DNA vaccine for COVID-19메틸화되지 않은 CpG 모티브를 함유한 바실러스 칼멧-게린의 게놈 DNA 단편은 COVID-19에 대한 DNA 백신에 대한 면역 반응을 향상시킵니다Article Published on 2021-10-012022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus addition adjuvant Antibody titers B.1.1.7 Bacillus Calmette-Guérin BALB/c mice BC01 adjuvant caused Cellular immune response coronavirus coronavirus disease coronavirus- COVID-19 CpG disease DNA DNA fragment DNA vaccine effective elicit expressing Genome Genomic DNA humoral immune response immune responses IMPROVE mice neutralize neutralizing antibody Neutralizing antibody titer neutralizing antibody titers pandemic produced respiratory SARS-CoV-2 SARS-CoV-2 spike protein sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein tested the SARS-CoV-2 unmethylated Vaccine vaccine candidate variants [DOI] 10.1016/j.vaccine.2021.08.103 PMC 바로가기 [Article Type] Article
Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional StudyProtocol Published on 2021-03-042022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] “COVID-19 African alleles amplification analyses Analysis Apoptosis apoptotic pathways association Bax BCL-2 BCL2L12 Biomarker carried caspase 3 categories caused CD4 collected Comorbidity complete blood count Concentration country COVID-19 COVID-19 complication COVID-19 pandemic cross-sectional Cytokine storm determinant determine Disease progression distribution DNA EDTA ELISA enrolled enzyme-linked immunosorbent expected expression expression level flow cytometry Frequency genetic determinants Genomic DNA genotyped genotypes genotypic genotyping Haplotype Hardy-Weinberg equilibrium Health health system help Hospitalized hospitalized patient Hypovitaminosis D Identifier Immunopathogenesis IMPROVE Improving include individual infected patients infected with SARS-CoV-2 information Lagos Linkage disequilibrium Lymphocyte count lymphopenia MONITOR Nigeria objective Other outcome participant Participants Patient PCR performed phenotypic polymerase chain polymorphism Prevalence Prognosis questionnaire R statistical software report Repurposed drug Result reverse transcribed reverse transcription PCR risk stratification RNA RNA sample RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–positive Sequencing serum sample serum vitamin D severe infections soluble Fas ligand Stratification study outcome T cell assay T lymphocyte Total Travel Treatment treatment regimen understanding vascular cell adhesion VDR venous blood Vitamin D receptor Vitamin D status with COVID-19 [DOI] 10.2196/21242 PMC 바로가기 [Article Type] Protocol
Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection폴리뉴클레오티드-아데노신 뉴클레오시다아제인 사포린은 SARS-CoV-2 감염에 효과적인 치료제가 될 수 있습니다Article Published on 2021-03-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] 진단, 치료제, [키워드] (rRNA abasic site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine agent Apoptosis Cell characteristic conserved coronavirus Coronavirus 2019 COVID-19 drug efficacious therapeutic enzymatic activity eukaryotic cells focus Genomic DNA high stability Hyperactivation Immunotherapy induce Infection inhibitor N-glycosidase Nucleosidase Pathways polymerase Protein protein synthesis residue respiratory ribosomal RNA RNA rRNA saporin. SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signal transduction Stress stress response therapeutic therapeutic agents toxin Treatment type I [DOI] 10.1177/2472555220970911 PMC 바로가기 [Article Type] Article
Disposable silicon-based all-in-one micro-qPCR for apid on-site detection of pathogens병원체의 신속한 현장 검출을 위한 일회용 실리콘 기반 all-in-one micro-qPCRArticle Published on 2020-12-022022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] against SARS-CoV agent cDNA Course detect Device Diagnosis diagnostic disease-causing effective Electrical and electronic engineering fragment of Genomic DNA infections Intervention lab Laboratory Mycobacterium Novel coronavirus novel coronavirus SARS-CoV-2 nucleic acid nucleic acids pathogen pathogen-specific Pathogens produced Quantitative Rapid Real-time PCR SARS-CoV-2 Sensors and biosensors Sensors and probes sequence silicon specificity Symptom Treatment [DOI] 10.1038/s41467-020-19911-6 PMC 바로가기 [Article Type] Article
Sensitive real-time PCR detection of Plasmodium falciparum parasites in whole blood by erythrocyte membrane protein 1 gene amplification전체 혈액에서 적혈구 막 단백질 1 유전자 증폭을 통한 말라리아 원충 플라스모디움 팔시파룸의 민감한 실시간 PCR 검출Research Published on 2019-04-022024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] Genomic DNA Parasitemia Plasmodium falciparum erythrocyte membrane protein 1 Real-time PCR [DOI] 10.1186/s12936-019-2743-9 PMC 바로가기 [Article Type] Research
Genome-wide detection of conservative site-specific recombination in bacteria박테리아에서 보존적 부위 특이적 재조합의 게놈 전체 검출Research Article Published on 2018-04-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition adopted Altering Analysis appear applicability applied approach archaeal Bacteria Bacterial bacterial specy characterization classical Clostridium difficile components condition conserved contributing to dataset dependent on described detect DNA ecological niche ecological niches Effectiveness Epidemic expand expressed Features fluctuations fluorescent Frequency Gene Expression generate genomes genomic Genomic DNA growth heterogeneity identify in some in vitro inversion lack lineages mechanism nucleotide occur opens pathogen pathogenic bacteria phenotypic platform Population population level Prevalence proliferation provide Rapid Recombination referred to responsible robust Sequencing single-nucleotide stationary strain subpopulation survival thought undergo Variation [DOI] 10.1371/journal.pgen.1007332 PMC 바로가기 [Article Type] Research Article