granzyme B – Page 2 – Communicable Diseases Research

Markers of Memory CD8 T Cells Depicting the Effect of the BNT162b2 mRNA COVID-19 Vaccine in Japan

일본에서 BNT162b2 mRNA COVID-19 백신의 효과를 나타내는 메모리 CD8 T 세포의 마커

Article

Published on 2022-04-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling

수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별

Article

Published on 2022-04-202022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] absolute neutrophil count Analysis Aritficial Intelligence biochemical biochemical markers Biochemical parameters Blood urea nitrogen C-reactive protein clinical Cohort control subject control subjects coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical curated cytokine Cytokines dataset differential expression disease severities Efficacy exploratory ferritin granzyme B highlight identify identifying IFN-γ IL-1 IL-10 IL-15 IL-1ra IL-6 immunological Increased Initially interferon Interferon-gamma interleukin investigated Lactate lactate dehydrogenase Liver injury machine machine learning methodology modeling multiplex Multiplex assay Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Necrosis neutrophil nitrogen outcome pandemic pathophysiology pathway Patient PD-L1 potential therapeutic targets predict Predictive predictive models Predictive value predictor radiological receptor RNA RNA seq ROC ROC analysis serum severe cases severity the disease transcriptomics tumor necrosis urea validation cohort variant
[DOI] 10.3389/fimmu.2022.865845 PMC 바로가기 [Article Type] Article

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

순찰 단핵구 및 CD16+ NK 세포의 TIM3+ TRBV11-2 T 세포 및 IFNγ 시그니처는 MIS-C를 설명합니다

Article

Published on 2022-02-072022-09-12
Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 진단,

Towards large-scale identification of HLA-restricted T cell epitopes from four vaccine candidate antigens in a malaria endemic community in Ghana

Article

Published on 2022-01-312024-08-28
Journal: Vaccine [Category] 말라리아,

[키워드] FluoroSpot Ghana granzyme B IFN-γ malaria T cells
[DOI] 10.1016/j.vaccine.2021.12.042

Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group

건강한 인구집단에서 CoronaVac 28일 일정 예방접종으로 유도된 면역 반응 평가

Immunology

Published on 2022-01-312022-09-11
Journal: Frontiers in Immunology [Category] 바이오마커, 진단,

Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma

Article

Published on 2022-01-282024-09-02
Journal: Cell Reports Medicine [Category] 대상포진,

[키워드] Adoptive Cell Therapy consolidation granzyme B hematology Immunotherapy immunotyping Myeloma NK cells
[DOI] 10.1016/j.xcrm.2022.100508 PMC 바로가기 [Article Type] Article

Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 Vaccination

Immunology

Published on 2022-01-252022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] Activation adaptive adenoviral vector vaccine adenovirus vector vaccine age antibody Antibody titer association AZD1222 B cell CD14 CD27 CD3 CD56 CD86 Cell ChAdOx1 nCoV-19 collected connection correlated CpG Critical cytokine production double-negative B cell enrolled Ex vivo expression first vaccination FIVE flow cytometry granzyme B IFN-γ IGD imiquimod Immune cell immune response Immunity immunosenescence information Innate innate immune innate immune activation innate immune response Innate immunity LPS marker memory B cell monocyte naïve naïve B cell natural killer neutralization Neutralizing antibodies neutralizing antibody NK cell Older pattern recognition receptor Production response responses Result SARS-CoV-2 vaccines SARS-CoV2 serum significantly higher stimulated subject sVNT TLR TLR agonist TLR stimulation TLR9 Toll-like receptor vaccination vaccinee Virus neutralization were measured
[DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology

Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection

생존한 고령 환자들은 SARS-CoV-2 감염 후 수개월 동안 세포 및 체액 면역학적 기억이 보존됨을 보여줍니다

Article

Published on 2022-01-072022-09-11
Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-N antibodies anti-N antibody anti-N IgG anti-S anti-S IgG antibodies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determined by donors effective ELISA ELISPOT enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Fewer patient Fewer patients granzyme B had more heterogeneity hospital Humoral response IFN-γ IgG1 immune responses Immunity Immunological memory immunosenescence in some infected individuals Infection interferon interferon-γ life lymphocyte Lymphocytes memory memory B memory B cell memory B cells memory B lymphocytes memory T memory T lymphocytes Month Older pandemic Patient Peripheral blood positively correlated preserved producer cell quantified recovered patient reduce resolved respiratory respond response responses robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe symptom show Specific specific antibodies specific immunity T lymphocyte T lymphocytes understanding Vaccination strategies virus were measured
[DOI] 10.1093/gerona/glab206 PMC 바로가기 [Article Type] Article

Role of Heat Shock Proteins in Immune Modulation in Malaria

Article

Published on 2021-12-312024-09-10
Journal: Adv Exp Med Biol [Category] 말라리아,

[키워드] eryptosis granzyme B Immunotherapy Infected erythrocyte natural killer cell Parasite heat shock protein.
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Early Response of CD8+ T Cells in COVID-19 Patients

Article

Published on 2021-12-032022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

[키워드] apoptotic CD3+ CD8 CD8+ CD8+ T cell CD8+ T cells Cell COVID-19 COVID-19 patient cytokine disease disease course downregulated effector memory FASL faster form Frequency gene expression pattern gene expression profile GNLY granulysin granzyme B granzymes GzmA GzmB GZMK healthy control healthy controls IFN-γ IFN-γ immune response interferon-γ investigated lack Ligand lymphocyte Mild Mild symptom moderate mRNA expression nine Patient perforin Peripheral blood predictor PRF1 progressed progression proportion Protein response SARS-COV-2 infection SARS-CoV2 significantly subpopulation the disease
[DOI] 10.3390/jpm11121291 PMC 바로가기 [Article Type] Article