Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2바이러스 E 단백질은 SARS-CoV-2의 BET 단백질 매개 진입 후 길항작용을 중화합니다Article Published on 2022-07-192022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 ACE2 expression acetylated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral antiviral response BET BET inhibitors BET proteins bind BRD2 BRD3 BRD4 bromodomain Cell coronavirus COVID-19 CP: Microbiology Critical Depletion domain downregulate E protein enzyme exacerbate Factor histone histone mimetic inactivated inactivation Infection inhibitor inhibitors interferon interferon response mice Microbiology Mortality neutralization neutralize overexpressing Protein Replication SARS-CoV-2 SARS-COV-2 infection Support suppresse treated Treatment viral replication [DOI] 10.1016/j.celrep.2022.111088 PMC 바로가기 [Article Type] Article
What is the impact of circulating histones in COVID-19: a systematic reviewReview Published on 2022-07-192023-07-10 Journal: Clinical chemistry and laboratory medicine [Category] COVID19(2023년), [키워드] citrullinated histone COVID-19 heparins and heparinoids histone NETosis NETs SARS-CoV-2 systematic review Thrombo-inflammation [DOI] 10.1515/cclm-2022-0574 [Article Type] Review
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and HistonesArticle Published on 2022-02-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] activated Adsorbent Adsorption binding Box Complication coronavirus disease COVID-19 deplete deregulated disease severity disorders driven by effector event Evidence expressing extracellular vesicle Extracellular vesicles Factor group heparin histone Histones HMGB1 immunothrombosis increased mortality marker multiorgan failure NETs Neutrophil extracellular trap Neutrophil extracellular traps Pathogens PF4 Platelet platelet factor 4 Platelets Protein Sepsis thrombosis thrombotic complication [DOI] 10.3390/ijms23031823 PMC 바로가기 [Article Type] Article
The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks흡연자에서 COVID-19의 불리한 임상 결과는 H3K4me3, H3K9me3 및 H3K27me3 히스톤 마크에 의해 매개됩니다Review Published on 2022-01-132022-09-11 Journal: Epigenomics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Abstract ACE2 Alter AT1R Clinical outcome COVID-19 CTSD CTSL deleterious effect Epigenetic epigenetic gene regulation epigenetics and disease Evidence expression favor H3K27me3 H3K4me3 HeK9me3 histone histone modifications IL-6 implicated indicate individual induce mdig mechanisms mediator modifications NRP1 NRP2 PGE2 proportion Protein recent receptor receptors regulate respiratory Respiratory disease respiratory diseases SARS-CoV-2 SARS-CoV-2 entry severe COVID-19 SLC6A20 smoker smoking Transcription turn upregulating Viral viral entry [DOI] 10.2217/epi-2021-0476 PMC 바로가기 [Article Type] Review
Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposingResearch article Published on 2021-12-012022-10-05 Journal: European journal of medicinal chemistry [Category] 신약개발, [키워드] addition Antitumor Apoptosis Cancer therapy cancers candidate cells cellular demethylase derivative dosage Drug repurposing effort EGFR enzyme epigenetic modulator Erlotinib FDA-approved drug histone IC50 implicated induce inhibit inhibitor inhibitory activity LSD1 lung cancer Migration Pathogenesis provide Quinazoline reduction in screened significantly specificity suppress suppressed therapeutic target Treatment [DOI] 10.1016/j.ejmech.2021.113778 [Article Type] Research article
COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical MarksCOVID-19는 다기관 공격자입니다: 후성 유전적 및 임상적 징후Review Published on 2021-10-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations chromatin clinical clinical manifestation clinical phenotype clinical phenotypes Clinical significance coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Cytokine storm DNA methylation driven by environmental factors Epigenetic epigenetics event Genetic highlight histone host genome Infection involved management MARK mechanisms multi-organ occur pro-inflammatory cytokines progression respiratory respond resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 survival therapeutic TMPRSS2 understanding Viral viral replication virus viruses with COVID-19 [DOI] 10.3389/fimmu.2021.752380 PMC 바로가기 [Article Type] Review
Histone H3 Cleavage in Severe COVID-19 ICU PatientsCellular and Infection Microbiology Published on 2021-09-102022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury Admission complex coronavirus disease COVID-19 damage-associated molecular pattern DAMPs DAMPs (damage-associated molecular patterns) Evolution Extracellular Extracellular histones histone ICU ICU - Intensive care unit ICU admission ICU Patients Infection Inflammatory diseases invasive ventilation marker MPO NET NETosis neutralization Neutrophil extracellular trap Patient patients plasma progression reduce released remained severe COVID-19 patients severity significantly increased subset Support targeted therapy the patient Thromboembolic event Treatment Validity Vasoactive [DOI] 10.3389/fcimb.2021.694186 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19COVID-19 환자를 위한 HDAC 억제제 발프로산의 잠재적인 용도 변경Review Published on 2021-05-052022-09-11 Journal: European journal of pharmacology [Category] SARS, 신약개발, [키워드] acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory effect cellular coronavirus disease Coronavirus-2 COVID-19 cytokine response distress drug Effect end-organ damage enzyme epilepsy expression HDAC HDAC inhibitor histone Histone deacetylase inhibitor immune Infection inhibitor mitigate modulate Patient patients with COVID-19 Potential Prevent reduce reducing required respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 viral Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic Therapeutic approach therapeutic approaches therapeutic target therapy transmembrane serine protease transmembrane serine protease 2 Valproic acid Valproic acid. [DOI] 10.1016/j.ejphar.2021.173988 PMC 바로가기 [Article Type] Review
An immune epigenetic insight to COVID-19 infectionCOVID-19 감염에 대한 면역 후성 유전학적 통찰력Review Published on 2021-03-092022-09-11 Journal: Epigenomics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus bromodomain CAP1 Coronavirus-2 COVID-19 COVID-19 infection CpG Critical determine DNA methylation Epigenetic evade event histone histone PTMs Host host cell Host immune response host-virus interaction Hsp90 IFN response immune immune evasion immunoepigenetics infected cells KDM5B mechanism Methylation modulating positive-sense RNA virus Protein regulate respiratory RNA virus SARS-CoV-2 SARS-CoV-2 protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 SIRT1 Type type I [DOI] 10.2217/epi-2020-0349 PMC 바로가기 [Article Type] Review