Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19COVID-19의 폐 배수 림프절에서 혈관 손상, 혈전 염증, 원형질모세포 활성화, T-세포 조절 장애 및 병리학적 조직구 반응Immunology Published on 2021-12-132022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] accumulation Activation alveolar damage Analysis Autopsy bronchoalveolar lavage sample bronchoalveolar lavage samples CD105 CD36 collected Control COVID-19 COVID-19 case DAD damage demonstrated Depletion Diffuse alveolar damage downregulation Draining draining lymph node dysfunction dysregulated immune response dysregulation EBV enrolled Epstein Barr virus evidence of evidenced expression profiling FIBRIN FLT1 follicular follicular hyperplasia FOXP3 Gene expression profiling germinal centers herpes Herpes virus herpes viruses histology HLH immunohistochemical staining immunological immunopathology incidence infectious mononucleosis initial LEF1 lymph Lymph node lymph nodes Macrophage macrophage activation marker maturation Microarray microthrombi Migration mounted node Panel pathological pathway peribronchial Peripheral blood phenotype plasmablast plasmablasts positive PROCR provided pulmonary Reactivation response responsible Sample SARS-CoV-2 selected severe COVID-19 staining T-cell T-cell dysregulation T-cells TEK Thromboinflammation thrombosis tissue tracheal upregulation viruses vWF was performed widespread [DOI] 10.3389/fimmu.2021.763098 PMC 바로가기 [Article Type] Immunology
Neutropenic Fever in a Patient With SARS-CoV-2-Induced Hemophagocytic Lymphohistiocytosis (HLH)Infectious Disease Published on 2021-12-022022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 2019 novel coronavirus Case report COVID-19 COVID-19 infection cytokine release storm develop etiology Fever follicular hemophagocytic lymphohistiocytosis Hemophagocytic lymphohistiocytosis (HLH) HLH Hospital admission immune dysregulation immunomodulatory drugs Neutropenic neutropenic fever non hodgkin's lymphoma Non-Hodgkin Lymphoma overlap Patient produced SARS-CoV-2 syndrome systemic inflammatory Treatment [DOI] 10.7759/cureus.20101 PMC 바로가기 [Article Type] Infectious Disease
Hemophagocytic histiocytosis in severe SARS-CoV-2 infection: A bone marrow study중증 SARS-CoV-2 감염에서 혈구포식세포 조직구증: 골수 연구Comparative Study Published on 2021-12-012022-09-11 Journal: International journal of laboratory hematology [Category] MERS, SARS, 바이오마커, [키워드] albumin analyzed BME Bone marrow bone marrow examination CD25 Cell clinical and laboratory features Corticosteroid corticosteroid therapy COVID-19 infection criteria CRP cytopenia cytopenias D-dimer Diagnostic Criteria disorder eight elevated Fever FIVE four of eight hemophagocytic lymphohistiocytosis Hemophagocytosis High-dose histiocytosis histiocytosis. HLH Hyperferritinemia hyperfibrinogenemia Hyperinflammatory hypertriglyceridemia Hypofibrinogenemia immune response initiated laboratory feature LDH Leukocytosis lymph nodes lymphocytopenia lymphocytosis marrow examination natural killer neutrophilia organomegaly overlap Patient patients plasma raised required SARS-CoV-2 serum albumin serum CRP Serum ferritin Severe COVID-19 Infection severe SARS-CoV-2 soluble CD25 spleen syndrome therapy transaminase transaminases Triglyceride triglycerides Viral viral infections [DOI] 10.1111/ijlh.13619 PMC 바로가기 [Article Type] Comparative Study
Systemic Lupus Erythematosus With Hemophagocytic Lymphohistiocytosis: Is COVID-19 the Inciting Factor?Infectious Disease Published on 2021-11-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] aberrant immune response acute respiratory syndrome Autoimmune disease cause caused characterized coronavirus COVID-19 Cytokine storm Diagnosis disease feature female ferritin hemophagocytic lymphohistiocytosis HLH immune activation Immune-mediated Infection Inflammatory marker initial life-threatening Lupus macrophage activation syndrome SARS-CoV-2 SLE Symptom systemic systemic lupus erythematosus tissues [DOI] 10.7759/cureus.19657 PMC 바로가기 [Article Type] Infectious Disease
Hemphagocytic Lymphohistiocytosis Secondary to COVID-19: A Case ReportInternal Medicine Published on 2021-11-052022-10-31 Journal: Cureus [Category] COVID-19, [키워드] autosomal recessive Coronavirus disease-19 COVID 19 COVID-19 covid-19 in pakistan COVID-19 pneumonia Critical disease disorder excessive immune response Fever Genes Hemophagocytic lymphohistiocytosis (HLH) high risk HLH Hyperinflammatory immune induce lymphohistiocytosis multiorgan failure Mutation outcomes Patient Post-COVID sequelae Regulatory report reported secondary secondary to severe COVID-19 syndrome triggered viral infection [DOI] 10.7759/cureus.19292 PMC 바로가기 [Article Type] Internal Medicine
Hemophagocytic lymphohistiocytosis in adults: A key issue in the COVID-19 eraResearch article Published on 2021-11-012022-10-05 Journal: Clinical Infection in Practice [Category] 변종, [키워드] Activation Affect approach characterized childhood COVID-19 COVID-19 pandemic death disorder dysregulation Genetic Haemophagocytic syndrome Hemophagocytosis HLH immune system information liver multiple organ failure mutations NK cells pathophysiology phagocytic reactive SARS-CoV-2 syndrome systemic inflammation TCD8 [DOI] 10.1016/j.clinpr.2021.100100 [Article Type] Research article
The Spectrum of Manifestations of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) Infection in Children: What We Can Learn From Multisystem Inflammatory Syndrome in Children (MIS-C)Medicine Published on 2021-10-282022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence acute SARS-CoV-2 infection ADE antibody Asymptomatic carrier Can capillary cardiac function children children with MIS-C clinically collected coronavirus disease 19 COVID-19 Critical defined definitive diagnosis develop disease etiology Evidence feature Fever heart failure hemodynamic hemophagocytic lymphohistiocytosis HLH Hospitalization hyperinflammation Hyperinflammatory immunological immunological profile Infection Inflammatory biomarker Inflammatory response Interpretation Isolation Laboratory manifestation mechanism MIS-C molecular Myocardial inflammation myocarditis observation occur organ Pathogenesis Patient patients pediatric positive serology preserved profiles respiratory responsible SARS-CoV2 SARSCoV-2 Severe infection Shock Spectrum symptomatic syndrome the disease toxic TSS Viral load [DOI] 10.3389/fmed.2021.747190 PMC 바로가기 [Article Type] Medicine
A case of coinfection of a pediatric patient with acute SARS-COV-2 with MIS-C and severe DENV-2 in Mexico: a case reportCase Report Published on 2021-10-182022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress ARDS Case report children clinical feature Clinical improvement Coinfection COVID-19 COVID-19 case DENV-2 edema exhibited fluid overload HLH Inflammatory intubation manuscript MIS-C multisystemic Patient pediatric Pediatric patient Pediatric patients Pneumonia released SARS-CoV-2 Septic shock Severe DENV Surveillance syndrome the epidemic Treatment triggered virus [DOI] 10.1186/s12879-021-06765-6 PMC 바로가기 [Article Type] Case Report
Discrimination of COVID-19 From Inflammation-Induced Cytokine Storm Syndromes Using Disease-Related Blood Biomarkers질병 관련 혈액 바이오마커를 사용한 염증 유발 사이토카인 폭풍 증후군과 COVID-19의 구별Article Published on 2021-10-012022-09-11 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] 바이오마커, [키워드] Activation Adhesion Molecule association Biomarker Biomarkers Characteristics classic condition correlation correlations Course COVID-19 Critical cytokine Cytokine storm discrimination disease drugs targeting dysregulation Efficacy enzyme-linked immunosorbent enzyme-linked immunosorbent assay healthy control healthy controls hemophagocytic lymphohistiocytosis high mortality HLH hyperinflammation IL-1 IL-1 receptor antagonist IL-8 immune activation immune dysregulation intercellular intercellular adhesion molecule interferon interleukin Interleukin-18 Level longitudinal samples Macrophage macrophage activation syndrome measurement Novel coronavirus novel coronavirus SARS-CoV-2 observation occur outcome pathway Pathways Patient patients patients with COVID-19 performed profile quantified receptor antagonist reduced SARS-COV-2 infection secondary hemophagocytic lymphohistiocytosis Serum level serum levels serum sample serum samples severe COVID-19 soluble Fas ligand storm subgroup of patients systemic cytokine systemic hyperinflammation thought Treatment treatment of COVID-19 Trigger triggers were assessed [DOI] 10.1002/art.41763 PMC 바로가기 [Article Type] Article
Secondary Hemophagocytic Lymphohistiocytosis in Post-COVID-19 Patients: A Report of Two CasesInfectious Disease Published on 2021-08-202022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Adults Affect Bone marrow children coronavirus COVID-19 COVID-19 positive patient diagnosed disease dysregulation hemophagocytic lymphohistiocytosis highlight HLH immune system pandemic post-COVID-19 patient report SARS-CoV-2 secondary secondary hemophagocytic lymphohistiocytosis serological test sHLH viral infections virus infection [DOI] 10.7759/cureus.17328 PMC 바로가기 [Article Type] Infectious Disease