Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19매우 심각하거나 치명적인 COVID-19가 있는 65세 미만의 피험자에서 드문 잠재적 병원성 변이의 존재Article Published on 2022-06-202022-09-11 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] affecting Analysis Blood coagulation carbohydrate cohort of patients components composed COVID-19 COVID-19 patient COVID-19 severity death Defense described DNA Exome explain fatal COVID-19 Genes Genetic variant genetic variants help Host host defense immune response immunodeficiency interconnected gene intubation involved mechanism metabolism network analysis outcome pathogen pathogenic pathogenic variant Pathogens Patient patients Presence Rare variants required resulting selected Sequencing subject variant variants variants of interest [DOI] 10.1038/s41598-022-14035-x PMC 바로가기 [Article Type] Article
When Poly(A) Binding Proteins Meet Viral Infections, Including SARS-CoV-2폴리(A) 결합 단백질이 SARS-CoV-2를 포함한 바이러스 감염을 만날 때Review Published on 2022-04-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activities activity Antiviral binding cellular cellular antiviral defense competing complex Critical Defense defense mechanism demonstrated evade Factors family Gene Expression Host host defense host protein Including key factor mechanism metabolism mRNA metabolism Perspective poly(A)-binding protein (PABP) promote Protein Replication SARS-CoV-2 stability subcellular localization targets translation translation initiation viral infection Viral infection. viral infections viral mRNA viral mRNAs virus viruses [DOI] 10.1128/jvi.00136-22 PMC 바로가기 [Article Type] Review
Association of TNF-α G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 PatientsTNF-α G-308 프로모터 다형성과 COVID-19 환자의 경과 및 결과와의 연관성Article Published on 2022-04-012022-09-11 Journal: Immunological investigations [Category] 유전자 메커니즘, [키워드] A allele age allele association Control Course COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients CRP cytokine Cytokines Defense defense mechanism demographic data Genotype genotypes Host host defense incidence Infection Laboratory lymphopenia mechanism Necrosis no statistically significant difference outcome Pathogenesis pathogenesis of COVID-19 Patient patients patients with COVID-19 polymorphism Prognosis promoter Serum ferritin severity and prognosis statistically significant difference tested the disease therapy TNF TNF-α tumor necrosis tumor necrosis factor tumor necrosis factor. university [DOI] 10.1080/08820139.2020.1851709 PMC 바로가기 [Article Type] Article
Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defenseArticle Published on 2022-03-222023-06-14 Journal: Cell Reports [Category] MERS, SARS, [키워드] endocytosis host defense Influenza interferon ISG proximity labeling RABGAP1L siRNA screening virus restriction VPS33A [DOI] 10.1016/j.celrep.2022.110549 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cellsSARS-CoV-2 Nsp13은 NKG2A 발현 NK 세포의 억제를 폐지하는 HLA-E 안정화 펩티드를 암호화합니다Article Published on 2022-03-082022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] abrogate activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen binding Cell contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense detect ENCODE epithelial cells HLA-E Host host defense human leukocyte antigen immune cells in vitro infected cells infections inhibitory receptor innate immune cell Innate immune cells leukocyte limit lung epithelial cell mechanism missing self. natural NK cell NK cells NKG2A non-structural protein Patient patients with COVID-19 peptide Prevent Protein respond resulting SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cell SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus susceptible target cell target cells These data virus [DOI] 10.1016/j.celrep.2022.110503 PMC 바로가기 [Article Type] Article
Iron dysregulation in COVID-19 and reciprocal evolution of SARS-CoV-2: Natura nihil frustra facitCOVID-19의 철 조절 장애와 SARS-CoV-2의 상호 진화: 자연적 현실Meta-Analysis Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 변종, [키워드] accompanied acquired immunity Analysis binding booster component conserved COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patients Defense Deterioration docking dysregulated dysregulation Evolution evolved variants Extensive ferritin ferritin-transferrin paradox Ferroportin followed by functional greater transmissibility Healthcare system hepcidin hospitalized patients Host host defense host proteases host range human host hypoxia immune evasion Immunity immunopathology in-silico Infection internalization involved iron iron homeostasis iron homeostasis. Iron metabolism iron overload lung MD simulation MD simulations mechanism Meta-analysis metabolism molecular molecular mimicry Mutation New omicron Omicron variant Pathogenesis pathway Patient peptide positive Prognosis protease Proteases provide responsible SARS-COV-2 infection selective Septic shock sequence serum severe COVID-19 severe disease Severe infection Severe patient severe patients shown Spike protein Spike protein sequence strain Structural analysis the spike protein tissue Transferrin vaccination variant variants variants of SARS-CoV-2 Viral load viral spike protein [DOI] 10.1002/jcb.30207 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways항바이러스 인터페론 경로에 대한 SARS-CoV-2 매개 회피 전략Review Published on 2022-03-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] COVID19(2023년), SARS, 변종, [키워드] Antiviral antiviral drug antiviral drugs coronavirus COVID-19 COVID-19 pandemic Defense determine develop effective effort evade Host host cell host defense IFN immune evasion Immune receptor Immunity Innate innate immune Interaction interferon interferon pathway interferon. mechanism Pathogenesis SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins Signaling signaling pathways Therapeutic strategies understanding Vaccine variants viral replication [DOI] 10.1007/s12275-022-1525-1 PMC 바로가기 [Article Type] Review
A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection새로운 글루코코르티코이드 및 안드로겐 수용체 조절제는 SARS-CoV-2 감염의 시리아 햄스터 모델에서 바이러스 진입 및 선천성 면역 염증 반응을 감소시킵니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] 2019-nCoV 2019-nCoV/USA-WA1/2020 ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration amplify Analysis androgen Androgen receptor angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animal animals antagonist antagonists bind caused CD4 Cell clinical development Clinical studies clinical study coronavirus COVID-19 Critical days post-infection decrease Defense domain dose-dependent DPI Efficacy enzyme examined expression glucocorticoid Glucocorticoid receptor golden hamster hamster Host host defense humans IL-6 indicated infiltration Inflammation inflammatory lung injury Inflammatory response Innate innate immune Innate immunity intranasally lack lung Lung histopathology Lung injury lung tissue Macrophage macrophages mechanism mechanism of action Model modulator molecular docking studies Molecular docking study novel oral administration outcome patients Phylogenetic analysis positive Predictive Prevent progression protease Protein PT150 receptor receptors reduce regulated Replication replication of SARS-CoV-2 required Research respiratory response Result SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection sequence identity Serine serine 2 severe acute respiratory syndrome Coronavirus shown strain surface protein T-cell T-cells TCID the cell therapeutic therapeutic efficacy Therapeutics tissue damage tissue injury TMPRSS2 transcriptional repressor transcriptionally transmembrane Treatment USA-WA1/2020 variants variants of SARS-CoV-2 Viral viral entry Viral load virus were infected [DOI] 10.3389/fimmu.2022.811430 PMC 바로가기 [Article Type] Immunology
Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19Covid-19의 처리를위한 유비 퀴 틸화 및 이슬 화 기계를 표적으로Review Published on 2022-02-122022-09-10 Journal: Biomolecules [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] A20 Activation avoidance COVID-19 CYLD effective enzyme Enzymes event highlight host defense host defense response host immune system host–pathogen interactions involved ISG15 ISGylation pathway Pattern recognition pattern recognition receptor PLPro post-translational modification protease Protein PRRs PTMs SARS-CoV-2 targeting the disease therapeutic intervention Treatment TRIM25 ubiquitin ubiquitin proteasome system ubiquitomics USP18 vaccine-resistant variant Viral viral replication virus viruses [DOI] 10.3390/biom12020300 PMC 바로가기 [Article Type] Review
Congenital and acquired defects of immunity: An ever-evolving story면역의 선천적 및 후천적 결함: 끊임없이 진화하는 이야기Article Published on 2022-01-012022-09-11 Journal: Pediatric allergy and immunology : official public [Category] SARS, 변종, [키워드] congenital Defense deficiency described disease disorder disorders DNA sequencing genomic data Host host defense immune immune regulation Immunity immunodeficiency immunodeficiency disorders Inborn Inborn errors inborn errors of immunity Interpretation involved Mutation new monogenic diseases of immunity PID Primary Immunodeficiency Primary immunodeficiency disorders primary immunodeficiency disorders. referred to reported SASH3 severe COVID-19 Signaling T-cell receptor TCR [DOI] 10.1111/pai.13632 PMC 바로가기 [Article Type] Article