Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2Article Published on 2022-10-062022-11-16 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affinity Analysis B.1.617.2 Beta bind binding binding affinity cell entry complex complex structure coronavirus Coronaviruses Delta Efficiency equine Equus functional Gamma hACE2 HCoV-NL63 HeLa cells high affinity horse human ACE2 indicated Infection infection assay molecular basis Mutation provide pseudovirus pseudovirus infection RBDs receptor Receptor binding domain Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 variant significantly increased spike receptor-binding domain the RBD the SARS-CoV-2 the spike protein Transmission zoonotic [DOI] 10.1016/j.str.2022.07.005 PMC 바로가기
Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessmentSARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type [DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spatiotemporal Genomic and Molecular Analysis of the First Wave of the COVID-19 Pandemic in Macaé, the Brazilian Capital of OilArticle Published on 2022-09-292022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, [키워드] Analysis B.1.1.28 B.1.1.33 Brazil Capital Clinical data COVID-19 COVID-19 pandemic COVID-19 severity death Epidemiology event functional genomic hotspot human ACE2 Integrative analysis Interaction Lineage Local Macaé molecular molecular interaction mutated Occurrence Oil outbreak Patient performed SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 virus infection second Spike protein Spread target the SARS-CoV-2 Transmission viral lineages viral mutation virus Wave wild-type [DOI] 10.3390/ijms231911497 PMC 바로가기
An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccinesArticle Published on 2022-09-222022-11-15 Journal: PLoS Pathogens [Category] SARS, 진단, [키워드] acute respiratory syndrome Asia bat bats Cell cell entry circulating COVID-19 pandemic Cross reactivity engage facilitate Health host cell Human human ACE2 human cells human pathogen identify individual infect Invasion Lineage majority monoclonal antibody outbreak pseudotype RBD receptor Receptor binding domain sarbecovirus SARS-CoV SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine serological serum tested the RBD Vaccine virus while [DOI] 10.1371/journal.ppat.1010828 PMC 바로가기
A Glycosylated RBD Protein Induces Enhanced Neutralizing Antibodies against Omicron and Other Variants with Improved Protection against SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] Affect antibody production B.1.1.529 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.2 Beta coronavirus COVID-19 COVID-19 vaccine Delta delta variant demonstrated develop disease severity domain effective effective vaccine Effectiveness Efficacy elicited enhanced enhanced protection epitope Epsilon Gamma global public health highlight human ACE2 immunized immunized mice immunodominant IMPROVE Improved improved neutralizing activity induce Lineage mice mutant mutated Mutation Neutralizing Neutralizing activity neutralizing antibody Neutralizing antibody titer Numerous omicron Omicron and other variants Other P.1 pandemic Prevent probe protection Protective Protein pseudotyped pseudovirus RBD RBD protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Strains subunit Subunit vaccine the receptor-binding domain threat Transmissibility Vaccine variant variants weight loss [DOI] 10.1128/jvi.00118-22 PMC 바로가기
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article
A decoy mutant ACE2 designed to reduce COVID-19COVID-19를 줄이기 위해 설계된 미끼 돌연변이 ACE2Article Published on 2022-09-012022-09-11 Journal: Trends in pharmacological sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 ARDS bind coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy disease expressing human ACE2 human lung cells Lung injury mice mutant New coronavirus reduce SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein Therapeutic strategies therapeutic strategy variant Viral pneumonia [DOI] 10.1016/j.tips.2022.02.010 PMC 바로가기 [Article Type] Article
Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into CellsArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Affect Alter analyzed bind binding Cell cells cellular entry coronavirus CoV CoVs Effect Efficiency expressing Genetic polymorphism glycoprotein HEK293T cell host cell membrane host susceptibility Human human ACE2 human Angiotensin-converting enzyme humans Infection Interaction investigated negatively affected plasma membrane Plasmid polymorphism previous study pseudotyped Pseudotyped viruses RBD RBD of SARS-CoV-2 Receptor binding domain relative infectivity reported S protein SARS CoV SARS-CoV SARS-CoV-2 severe pneumonia significantly Single nucleotide variant SNPs SNV SNVs Spike protein stomatitis Substitution suggested Support susceptibility the binding affinity the S protein the SARS-CoV-2 thought transfected with variants of concern viral entry viral surface virus virus entry virus infection viruses were infected wild-type [DOI] 10.1128/spectrum.00870-22 PMC 바로가기
High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronavirusesOmicron SARS-CoV-2 및 사전 출현 코로나바이러스에 대한 친화성 성숙 ACE2 유인물의 높은 활성Article Published on 2022-08-252022-09-11 Journal: PLoS ONE [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adeno-associated virus affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenic antigenic drift binding can not clade complicate coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic decoy develop drug Efficacy Evolution exceptional genetic diversity human ACE2 inhibitor intranasal intrinsic mitigate monoclonal antibody mutant nanomolar affinity Neutralizing omicron pandemic populations preparation Prophylaxis receptor Receptor-binding domain sarbecovirus Sarbecoviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein the SARS-CoV-2 the spike protein therapeutic Threats Treatment Vaccine variant variants viral evolution viral genome viral spike viral strain viral strains virus widespread zoonotic [DOI] 10.1371/journal.pone.0271359 PMC 바로가기 [Article Type] Article
Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escapeOmicron SARS-CoV-2 돌연변이는 스파이크 업-RBD 형태를 안정화하고 비-RBM-결합 단일클론 항체 탈출을 유도합니다Article Published on 2022-08-242022-09-11 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Accessibility ACE2 binding Analysis antibody complexes conformational change cryo-EM ENhance epitope expand human ACE2 immune evasion mechanism monoclonal antibody Mutation neutralizing antibody omicron performed Prevent prototype Receptor binding restrict S309 SARS-CoV-2 SARS-CoV-2 mutation stability Substitution substitutions target triggered up-RBD variants of concern VOCs [DOI] 10.1038/s41467-022-32665-7 PMC 바로가기 [Article Type] Article