The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach새로운 SARS-CoV-2 변이체 Omicron(B.1.1.529)이 백신 효능에 미치는 영향, Delta 변이체와의 상관관계: 전산적 접근Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Analysis antibody approach AY.1 B.1.1.529 binding affinity caused computational analysis correlation COVID CR3022 Delta Delta variants docking docking analysis domain Effect Efficacy Host hosts human ACE2 receptor human monoclonal antibodies Human monoclonal antibody immune evasion in silico Approach In-silico analysis Interaction lead MD simulation Modification Mutation neutralizing antibody new SARS-CoV-2 omicron Omicron variant pathogenicity promote Proteins RBD RBD variant Reinfection SARS-CoV-2 variant Spike proteins Strains Structure the binding affinity the WHO Vaccine variant [DOI] 10.1016/j.micpath.2022.105619 PMC 바로가기 [Article Type] Article
Predictive Models of within- and between-Species SARS-CoV-2 Transmissibility종 내 및 종 간 SARS-CoV-2 전염성 예측 모델Article Published on 2022-07-192022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 complex Coronaviridae Coronaviridae family coronavirus enzyme expected feature host receptor hosts human ACE2 receptor humans in silico infect Infection interact interfacing residues Model Mutation pandemic Positive selection positively correlated predict predicted Prediction model Protein receptor complex replacement reported reservoir residue residues S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant SARS-CoV-2 variants shown species spike spike glycoprotein spike glycoprotein (S). subtype Subtypes susceptible the Coronaviridae the SARS-CoV-2 thought Transmissibility transmissibility of SARS-CoV-2 virus [DOI] 10.3390/v14071565 PMC 바로가기 [Article Type] Article
Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19COVID-19의 구강 증상의 병원성 메커니즘 및 다중 오믹스 분석Review Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Analysis bind caused clinical manifestation clinical manifestations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokines decrease droplets dysfunction dysregulation Factors Gustatory Host host cell host cells human ACE2 receptor immune immune cells immune dysregulation immune response Immunological analyses immunological analysis include infect Inflammation manifestation mount multi Multi-omics multiple organ failure Numerous oral oral cavity pathogen pathogenic phenotype reported respiratory distress respiratory infectious disease S protein Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 Spread structural protein structural proteins syndrome the S protein Trigger virus Xerostomia [DOI] 10.3389/fimmu.2022.879792 PMC 바로가기 [Article Type] Review
Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice알코올은 폐 안지오텐신 전환 효소 2 발현을 증가시키고 중증 급성 호흡기 증후군을 악화시킨다Article Published on 2022-07-012022-09-11 Journal: The American journal of pathology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alcohol Alcohol Abuse alcohol consumption alveolar Alveolar space angiotensin angiotensin-converting enzyme 2 Biomarker blood cell body weight Bronchoalveolar lavage fluid chronic coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course Cytokine storm decrease dramatic increase enzyme Ethanol Express Factor human ACE2 receptor Human angiotensin-converting enzyme 2 Immune cell immune cells increase Inflammasome Interaction K18-hACE2 lung tissue mechanism mice Mortality NF-κB NLR NLRP3 overexpression pandemic parenchymal proinflammatory protein 3 recruitment reported respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike Spike protein STAT3 Stress subunit syndrome Therapeutic approach therapeutic approaches transgenic mice White blood cell worsening [DOI] 10.1016/j.ajpath.2022.03.012 PMC 바로가기 [Article Type] Article
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination예방 접종 없이 SARS-CoV-2 Omicron에 대한 제한된 교차 변이 면역Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] Activation arise Brain brains Breakthrough infection cause Cytokines Delta disease elicited ENhance expression human ACE2 receptor humans humoral immune response Immunity individual individuals induce Infection infections lead Limited lung Lung disease Lungs mice Mild Mild disease neutralization neutralize omicron other variant overexpressing pandemic pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines question reduced replicate risk SARS-CoV-2 SARS-CoV-2 delta sera Symptoms T cells titre vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern WA1 widespread [DOI] 10.1038/s41586-022-04865-0 PMC 바로가기 [Article Type] Article
Probing structural basis for enhanced binding of SARS-CoV-2 P.1 variant spike protein with the human ACE2 receptorSARS-CoV-2 P.1 변이체 스파이크 단백질과 인간 ACE2 수용체의 향상된 결합을 위한 구조적 기초 조사Article Published on 2022-07-012022-09-11 Journal: Journal of cellular biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Analysis angiotensin angiotensin converting enzyme approach binding circulating commonality Comparative analysis complex conformational change Contact coronavirus COVID-19 cumulative cumulative effect demonstrated enzyme host receptor human ACE2 receptor Infection initial Interaction investigated molecular molecular dynamic simulation Mutation P.1 variant P.1 variants Probing Protein protein network analysis provide RBD RBD residue RBD residues RBD-ACE2 receptor Receptor binding domain reported responsible S1 domain SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein the RBD the spike protein unique variant variants virus transmission wild type [DOI] 10.1002/jcb.30276 PMC 바로가기 [Article Type] Article
Singular Interface Dynamics of the SARS-CoV-2 Delta Variant Explained with Contact Perturbation Analysis접촉 섭동 분석으로 설명되는 SARS-CoV-2 Delta 변이체의 단일 인터페이스 역학Article Published on 2022-06-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 Alpha Analysis angiotensin Beta can not changes in Contact contact with COVID-19 pandemic crystallographic structure Delta delta variant Delta variants Dihedral angle direct contact drastic Dynamics Epsilon explain FIVE Gamma human ACE2 receptor human Angiotensin-converting enzyme interface L452R mechanism of action molecular molecular dynamics Mutation outcome pandemic PCA Perturbation Principal component principal component analysis provoke raise RBD receptor Receptor binding domain residue SARS-CoV-2 variant similarity singular Spike protein Spike receptor binding domain T478K the SARS-CoV-2 the spike protein variant variants wild type [DOI] 10.1021/acs.jcim.2c00350 PMC 바로가기 [Article Type] Article
Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variantsSARS-CoV-2 알파, 델타 및 오미크론 변이체의 스파이크 단백질에서 RBD에 대한 돌연변이 평가Article Published on 2022-05-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] accelerated ACE2 acute respiratory syndrome affinity angiotensin antibody resistance Arg assessment binding binding affinity charged residue conformational coronavirus correlated Critical Delta domain evaluate faster free energy Free energy calculation Free energy calculations human ACE2 receptor human Angiotensin-converting enzyme Impact Interaction molecular molecular dynamics Mutation occur omicron other variant other variants Protein provided RBD receptor residue S protein S protein RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 virus Severe acute respiratory syndrome spike Spike protein spike protein RBD Spread systematic analysis T478K the RBD the SARS-CoV-2 the Spike variant variants [DOI] 10.1038/s41598-022-12479-9 PMC 바로가기 [Article Type] Article
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in miceClofoctol은 SARS-CoV-2 복제를 억제하고 쥐의 폐 병리를 감소시킵니다Article Published on 2022-05-192022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] antiviral activity Bacterial cells Clofoctol Compound compounds COVID-19 patients drug Drug repurposing exhibited exhibiting Gene Expression geographical areas human ACE2 receptor human lung IC50 identify Inflammatory inhibit investigated library Lung pathology mice peak concentration pharmacokinetic Pulmonary pathology reduce reduced Registered Regulatory Respiratory tract infections safety profile SARS-CoV-2 SARS-CoV-2 replication screened Support tested therapeutic Therapeutic treatment These data transgenic mice Treatment treatment of COVID-19 patients Viral load [DOI] 10.1371/journal.ppat.1010498 PMC 바로가기 [Article Type] Article
Structure-Based Development of SARS-CoV-2 Spike InteractorsSARS-CoV-2 스파이크 인터랙터의 구조 기반 개발Article Published on 2022-05-172022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor adopted affinities angiotensin approach B.1.617.2 binding binding affinity coronavirus Coronaviruses COVID-19 COVID-19 pandemic development diagnostic Dissociation constant domain ENhance etiological agent Host host cells human ACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Infectious disease inhibit Interaction interfere melting temperature molecular molecular dynamics Protein protein structure RBD Receptor-binding domain Recognition S1 domain SARS-CoV-2 SARS-CoV-2 spike protein single-point mutations spike spike glycoprotein Spike protein stability starting temperature the SARS-CoV-2 the spike protein variant of SARS-CoV-2 viral entry [DOI] 10.3390/ijms23105601 PMC 바로가기 [Article Type] Article