Longitudinal analysis to characterize classes and subclasses of antibody responses to recombinant receptor-binding protein (RBD) of SARS-CoV-2 in COVID-19 patients in Thailand태국의 COVID-19 환자에서 SARS-COV-2의 재조합 수용체-결합 단백질 (RBD)에 대한 항체 반응의 클래스 및 서브 클래스를 특성화하기위한 종단 분석Research Article Published on 2021-08-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analysis angiotensin Angiotensin-converting enzyme antibody Antibody assays Antibody Response Antibody responses contribute convalescent sera convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 patients Dengue fever detect domain ELISA ELISAs febrile healthy individual healthy individuals highest Host Human human immune response IgA IgG IgG level IgG levels IgG subclasse IgG subclasses IgG1 IgG3 IgM immune responses Infection Influenza Interpretation investigated leptospirosis longitudinal median molecular assays murine murine typhus natural infection ORF1ab ORF1ab gene outbreak Patient patients patients with COVID-19 Protein RBD RBD antigen reactivity respiratory RT-PCR SARS-CoV-2 SARS-COV-2 infection sera serological assays serum serum sample serum samples severe acute respiratory syndrome Coronavirus significantly higher Spike protein target tested Therapeutics tropical typhus Viral Viral detection viral spike protein [DOI] 10.1371/journal.pone.0255796 PMC 바로가기 [Article Type] Research Article
Antibody and B cell responses to SARS-CoV-2 infection and vaccinationSARS-CoV-2 감염 및 예방접종에 대한 항체 및 B 세포 반응Review Published on 2021-07-142022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 비임상, 진단, [키워드] antibody Antibody Response Antibody responses B cell B cell response caused cell population cellular component contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity Effective vaccines Effectiveness human immune response Human immune system immune responses Immunity independent Infection modulating pandemic pathogen plasma Plasma cell question replicated responses responsible SARS-CoV-2 SARS-COV-2 infection serological vaccination Viral viral variant Viral variants [DOI] 10.1016/j.chom.2021.06.009 PMC 바로가기 [Article Type] Review
SARS-CoV-2 antibody kinetics eight months from COVID-19 onset: Persistence of spike antibodies but loss of neutralizing antibodies in 24% of convalescent plasma donorsSARS-CoV-2 항체 역학 COVID-19 발병 후 8개월: 회복기 혈장 공여자의 24%에서 스파이크 항체는 지속되지만 중화 항체 손실Clinical Trial Published on 2021-07-012022-09-11 Journal: European journal of internal medicine [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] Analysis anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody Antibody Response Antibody responses Antigen antigens Characteristics contraction convalescent plasma COVID-19 decrease Donor eight faster Follow-up Hospitalization human immune response Immunity intervals linear median monitoring Multivariate analysis multivariate regression analysis neutralization ability Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid Older age participated Patient persistence Phase 2 Phase 2 study random-effect regression analysis response Result SARS-CoV-2 SARS-CoV-2 antibody spike Spike. symptom onset symptoms onset tested Vaccination strategies Vaccine [DOI] 10.1016/j.ejim.2021.05.010 PMC 바로가기 [Article Type] Clinical Trial
Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021Research Article Published on 2021-06-152022-10-29 Journal: mSystems [Category] COVID-19, [키워드] affecting Amino acid Amplicon antigenicity B.1.1.7 B.1.351 Brazil can be used Clinical data collected COVID-19 COVID-19 pandemic Critical detect Direct detection E484K Efficacy England Environmental surveillance Frequency growth help human immune response in viral increase increase in independent investigated Lineage B.1.1.7 London Mutation new SARS-CoV-2 Next-generation sequencing P.1 prevalent quantification raise raising Rapid RNA Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Sequencing analysis sewage shown South Africa spike mutation Surveillance the spike protein Transmission Vaccine variant variant B.1.1.7 variant of concern variants of concern virus virus virus transmission viruses VoC VOCs wastewater widespread [DOI] 10.1128/mSystems.00353-21 PMC 바로가기 [Article Type] Research Article
Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent BibliometricsResearch Metrics and Analytics Published on 2021-05-242022-10-31 Journal: Frontiers in Research Metrics and Analytics [Category] COVID-19, [키워드] ACE2 administration Analysis Bibliometrics caused China COVID-19 COVID-19 pandemic CXCL10 Evidence Gene Expression Genetic genetic research genetics global public health help human coronaviruses human immune response IL6 immune immune reaction Impact include Infection ISG15 Knowledge discovery mechanisms molecular network analytics OAS1 OAS2 OAS3 Patient Profiling public health Research researcher SARS-CoV-2 the disease The United States TMPRSS2 TNF Vaccine development virus virus infection [DOI] 10.3389/frma.2021.683212 PMC 바로가기 [Article Type] Research Metrics and Analytics
Prediction and Evolution of the Molecular Fitness of SARS-CoV-2 Variants: Introducing SpikeProArticle Published on 2021-05-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Accuracy ACE2 receptor Amino acid Characteristics circulating Clinical data COVID-19 Critical deep mutagenesis dominant driving epidemiological Evolution example fitness genomic human immune response identify Immune escape molecular mechanism Neutralizing antibodies population level predict predicted prediction protein binding affinity protein stability SARS-CoV-2 sequence Spike protein variants stability Surveillance the binding affinity the SARS-CoV-2 the SARS-CoV-2 virus the spike protein time-consuming Transmissibility variant viral fitness viral strain viral strains virus [DOI] 10.3390/v13050935 PMC 바로가기 [Article Type] Article
Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infectionsResearch Published on 2021-05-042022-11-01 Journal: Gut Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome Antibody detection association blastocyst Chest conducted connection Coronavirus-2 COVID-19 case COVID-19 infection COVID-19 infections cryptosporidium decrease diagnosis of COVID-19 died effort Endemic extreme Giardia hospital human immune response Hypothesis IFN-γ IgM and IgG Immune homeostasis immune system Infection interferon interferon gamma majority manifestation Mild moderate modulation nucleic acid Patient Quantitative regions reported Research Result role SARS-CoV-2-positive patient severe cases severity of COVID-19 Severity of infection significantly Stool examination susceptibility Symptoms therapeutic Toxoplasma Toxoplasma gondii [DOI] 10.1186/s13099-021-00427-3 PMC 바로가기 [Article Type] Research
Base Composition and Host Adaptation of the SARS-CoV-2: Insight From the Codon Usage PerspectiveMicrobiology Published on 2021-04-062022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome adaptation adaptive Analysis avoidance base base composition Clinical severity coding sequences codon codon adaptation index codon pair usage codon usage complex interplay coronavirus CpG dinucleotide event Factor gene product Host host adaptation hosts human host human immune response human populations information insight MERS Middle East multivariate natural selection progression raised Research robust SARS-CoV SARS-CoV-2 statistical analysis syndrome Transmission dynamics Usage Vaccine viral isolate virus [DOI] 10.3389/fmicb.2021.548275 PMC 바로가기 [Article Type] Microbiology
Evaluating Use Cases for Human Challenge Trials in Accelerating SARS-CoV-2 Vaccine DevelopmentSARS-CoV-2 백신 개발을 가속화하기 위한 인간 챌린지 시험의 사용 사례 평가Article Published on 2021-02-162022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Fulltext, MERS, 임상, [키워드] accelerate challenge controlled human infection COVID-19 development Efficacy effort Evaluating HCT Human human challenge trial human immune response human infection identify limitation option pandemic Pathogenesis preparation preserved SARS-CoV-2 SARS-CoV-2 vaccine Stage Trial use cases utility Vaccine vaccine candidate vaccine candidates vaccine evaluation. virus [DOI] 10.1093/cid/ciaa935 PMC 바로가기 [Article Type] Article
A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection네트워크 기반 분석은 SARS-CoV-2 감염에서 사이토카인 폭풍과 바이러스를 억제하는 비타민 D의 기본 메커니즘을 보여줍니다.Immunology Published on 2020-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] 2019 activating Antiviral antiviral response approach bind bioinformatics cause Cell Cluster Combination coronavirus COVID-19 Critical cytokine Cytokine storm Cytokines Defense depth analysis differentially expressed epithelial experimental validation expression Extensive fibrosis finding Functional enrichment analysis generate Genes highest host gene host genes host response human immune response IFN-α immune in-depth analysis infect Inflammatory Inflammatory response inhibit initiate ISGs leads Lower respiratory tract Lung fibrosis MCODE score mechanism molecular mechanism NFkB1 NHBE Organ failure pandemic pathway Pathways Patient potential mechanism POU2F2 pro-inflammatory cytokine pro-inflammatory cytokines protein-protein interaction receptor reducing referred to Regulation regulatory network respiratory Result resulting RNA sequencing robust antiviral response SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patients severe pneumonia Signaling signaling pathway STAT Stat1 STAT2 STAT3 storm suggested Suppressing Systems biology the cells the cytokine storm TNF transcription factor transcription factors Transcriptome Tuberculosis up-regulated Viral viral infection Vitamin Vitamin D were used [DOI] 10.3389/fimmu.2020.590459 PMC 바로가기 [Article Type] Immunology