Structural basis for the interaction of SARS‐CoV ‐2 virulence factor nsp1 with DNA polymerase α–primaseSARS -COV -2 독성 인자 NSP1과 DNA 폴리머 라제 α -Primase의 상호 작용을위한 구조적 기초Full‐Length Paper Published on 2021-11-122022-09-10 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), Fulltext, MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding biochemical biochemical evidence causative agent complex component coronavirus coronavirus disease Coronavirus disease 2019 cryo‐EM DNA DNA polymerase DNA polymerase α–primase genomic host protein human protein human proteins immune response Infection Interaction interfere Microscopy molecular mechanism molecular mechanisms nonstructural protein 1 nsp1 PDB polymerase prevented protein–protein interaction proteomic purified recent reported respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 scrutiny severe acute respiratory syndrome Coronavirus target the disease Viral viral infection virulence virulence factor virus [DOI] 10.1002/pro.4220 PMC 바로가기 [Article Type] Full‐Length Paper
Increased in vitro neutralizing activity of SARS-CoV-2 IgA1 dimers compared to monomers and IgG단량체 및 IgG에 비해 SARS-CoV-2 IgA1 이량체의 시험관 내 중화 활성 증가Article Published on 2021-11-022022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen antigen binding binding complex coronavirus exhibited expressed expression feature glycosylation homogeneous human proteins IgA IgG IgG1 in vitro Increased monoclonal monoclonal antibodies monomer Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody Nicotiana benthamiana plant plant expression plants respiratory SARS-CoV-2 SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus significantly increased variant Variation [DOI] 10.1073/pnas.2107148118 PMC 바로가기 [Article Type] Article
Prediction of severe adverse events, modes of action and drug treatments for COVID-19’s complicationsCOVID-19의 합병증에 대한 심각한 부작용, 작용 방식 및 약물 치료 예측Article Published on 2021-10-212022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] adverse events blood clot Blood clots category clinical manifestation clinical manifestations Comorbidity Complication complications Computational biology and bioinformatics Computational models COVID-19 patient COVID-19 phenotypes cytokine Cytokine storms disease drug Drug discovery Drug screening drug treatment drug treatments etiology FDA-approved drug FDA-approved drugs GWAS hallmark help Host human protein human proteins input Ligand machine learning mapped methodology molecular basis molecular feature molecular features molecular mechanism Molecular medicine neoplasm Neoplasms Neurological symptoms oncogenesis oncovirus Pathway analysis predict predicted prediction Prevalence Protein protein targets Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection severe adverse event severe adverse events Signs and symptoms subject Target identification treat Viral viral replication Virtual drug screening [DOI] 10.1038/s41598-021-00368-6 PMC 바로가기 [Article Type] Article
Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics ApproachIn Silico Proteomics 접근법에 의한 SARS-CoV-2 진단 및 백신 개발을 위한 고유 펩티드 식별Immunology Published on 2021-09-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] A549 cell line A549 cell lines acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergens Analysis Antigen antigenic peptide antigenic peptides antigenicity approach B-cell binding affinity cell line complexes coronavirus COVID-19 COVID-19 diagnosis COVID-19 patients COVID-19 vaccines crystal structure crystal structures develop development diagnostic diagnostic peptides diagnostics disorders docking effort evaluated Evolution examined help histocompatibility complex human proteins human saliva identification immunogenicity in-silico Initially major histocompatibility complex MHC Microbiome paratopes pathogenic peptide peptides Polymorphisms proteomic proteomics respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2-specific antibodies screened selected sequence similarity severe acute respiratory syndrome Coronavirus specific antibodies T-cell receptor TCR tested Toxicity Treatment unique utility Viral virus strain virus strains [DOI] 10.3389/fimmu.2021.725240 PMC 바로가기 [Article Type] Immunology
Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidatesCovid-19에서 바이러스 표적 및 차별적으로 발현 된 유전자의 네트워크 이웃은 약물 표적 후보입니다.Article Published on 2021-09-232022-08-31 Journal: Scientific Reports [Category] SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] Algorithm artificial intelligence candidate Computational biology and bioinformatics COVID-19 COVID-19 pandemic COVID-19 symptoms Data integration Data mining differentially expressed differentially expressed gene Diseases drug drug target drugs targeting Explainable artificial intelligence FDA-approved drugs human protein human proteins Infection Interaction interactions interactome mechanism mechanisms methodology network Network topology nitric oxide pathway predict protein interactions SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Signaling target the disease VEGF [DOI] 10.1038/s41598-021-98289-x PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanismsArticle Published on 2021-09-142022-10-31 Journal: Molecular Systems Biology [Category] COVID-19, SARS, [키워드] 3D model 3D structure bioinformatics can be used complex Coronavirus infection Coverage COVID‐19 Data visualization forms help Host human proteins implicated knowledge mechanism Methods & Resources Microbiology, Virology & Host Pathogen Interaction modifications proteome provide provided resource resulting reveal SARS‐CoV‐2 SARS‐CoV‐2 proteins SARS‐CoV‐2 structural biology structures translation Viral protein viral replication [DOI] 10.15252/msb.202010079 PMC 바로가기 [Article Type] Article
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesisSARS-CoV-2와 인간 코로나바이러스의 상호작용은 잠재적으로 병인에 영향을 미치는 숙주 요인을 나타냅니다Article Published on 2021-09-012022-09-11 Journal: The EMBO Journal [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Affinity purification BioID2 cellular response Cellular responses comparison conducted coronavirus COVID-19 disease disease pathology drug target encoded viral proteins explain Factor Host host cell host cells host-virus protein-protein interaction human coronavirus human coronaviruses human protein human proteins Interaction interactome life cycle nsp1 Pathogenesis pathway Protein protein-protein interaction Proteins provide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus SFB-TAP survival These data these viruses treating Treatment treatment of COVID-19 valuable resource Viral proteins virus [DOI] 10.15252/embj.2021107776 PMC 바로가기 [Article Type] Article
Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesisCOVID-19 발병 과정에서 취약한 숙주 단백질을 식별하기 위한 SARS-CoV-2의 숙주-바이러스 상호작용 분석Article Published on 2021-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, [키워드] Analysis CANX CAPZB cellular centrality complex composed COVID-19 COVID-19 pathogenesis Critical disease Diseases effort functional enrichment Functional enrichment analysis Genetic Host host protein HSPA1A HSPA5 human proteins human respiratory tract identify identifying IGF2R infection mechanism interactions involved ITCH Laboratory molecular mechanism molecular mechanisms neurodegenerative Pathogenesis Pathways performed potential therapeutic targets produced Protein protein-protein interaction Proteins PSMC5 RAB5A RAB7A RAB8A RBX1 Respiratory tract diseases SARS-CoV-2 Signaling therapeutic target therapeutic targets [DOI] 10.1016/j.meegid.2021.104921 PMC 바로가기 [Article Type] Article
Homology between SARS CoV-2 and human proteinsArticle Published on 2021-08-252022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Autoimmune Autoimmune response Computational biology and bioinformatics contagiousness database dysfunction homologous human protein human proteins immune system indicate Infection innate immune system involved motif nonstructural protein olfactory ORF3a ORF7a ORF7b ORF8 Orf9b Organisms primary structure Protein protein domain proteome provoke provoking receptors SARS CoV-2 SARS-CoV-2 sequence similarity the S protein transmembrane domain virus [DOI] 10.1038/s41598-021-96233-7 PMC 바로가기 [Article Type] Article
Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/LResearch Article Published on 2021-08-182022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] activate analyzed cathepsin Combination Compound COVID-19 CTSL cysteine proteases drug drug combination Effect enrichment analysis entry pathway expression gene expression signature gene-gene interaction Genes GSEA host cells host protease human proteins identify interact molecular docking analysis performed potential treatment option Proteases regulatory element SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 proteins serine protease target the spike protein Therapeutic benefit therapy TMPRSS2 transmembrane serine protease upstream [DOI] 10.1371/journal.pone.0256141 PMC 바로가기 [Article Type] Research Article