Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study안지오텐신 전환 효소-1 유전자 삽입/제거 다형성이 COVID-19 임상 중증도와 관련될 수 있음: 전향적 코호트 연구Article Published on 2021-05-012022-09-11 Journal: Annals of Saudi medicine [Category] 바이오마커, 변종, [키워드] 95 % CI 95% CI ACE advanced age agarose gel electrophoresis age angiotensin Asymptomatic Asymptomatic disease asymptomatic patients Care Chain Reaction Clinical data Clinical severity cohort study collected Comorbidity conflict conflict of interest COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients determined by diabetes Diabetes Mellitus died disease disease severity dominant enzyme frequencies Frequency Genotype heart disease hospital I/D I/D genotype I/D polymorphism independent risk factor independent risk factors insertion/deletion ischemic heart disease Mild nine outcome Pathogenesis Patient polymerase chain polymerase chain reaction polymorphism Prospective prospective cohort study Protective Sample Sample size severe COVID-19 severe disease significantly single center small sample size Tertiary whole blood sample with COVID-19 [DOI] 10.5144/0256-4947.2021.141 PMC 바로가기 [Article Type] Article
CCR5Delta32 deletion as a protective factor in Czech first-wave COVID-19 subjects체코 1세대 COVID-19 피험자에서 보호 인자로서의 CCR5Delta32 결실Article Published on 2021-03-172022-09-11 Journal: Physiological research [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic candidate carrier carriers cause CCR5 cells Chemokine receptor coronavirus coronavirus disease Course COVID-19 Deletion ENCODE first-wave Frequency Genetic genetic mutation genetic susceptibility genotyped globe highest HIV-1 HIV-1 infection homozygous I/D polymorphism Infection inter-individual lowest middle Mutation Patient predict PROTECT Protective protective factor Protein receptor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity Significant Spread subject subjects survivor symptomatic virus [DOI] 10.33549/physiolres.934647 PMC 바로가기 [Article Type] Article
Ethnic and age-specific acute lung injury/acute respiratory distress syndrome risk associated with angiotensin-converting enzyme insertion/deletion polymorphisms, implications for COVID-19: A meta-analysis인종 및 연령별 급성 폐 손상/급성 호흡 곤란 증후군 위험, 안지오텐신 전환 효소 삽입/제거 다형성, COVID-19에 대한 시사점: 메타 분석Meta-Analysis Published on 2021-03-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] 95% CI 95% confidence interval ACE acute lung injury acute respiratory distress syndrome addressed Adults ALI/ARDS allele analyses Analysis angiotensin Angiotensin-converting enzyme ARDS ARDS patient ARDS patients article Asian Asians assessment association associations Bonferroni correction Caucasian Caucasians children CIs Comparisons conducted coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 distress dominant Ethnicity examined genetic model Genotype healthy control healthy controls heterogeneity I/D I/D polymorphism implication include indicated insertion/deletion life lung Lung injury Meta-analysis meta-regression Mortality Odds ratios outcome outlier pandemic Patient patients with COVID-19 polymorphism Polymorphisms Regression reported respiratory distress Respiratory distress syndrome risk robust robustness Significant Statistical power statistically Subgroup analyses subgroup analysis syndrome therapy Topic Treatment was performed [DOI] 10.1016/j.meegid.2020.104682 PMC 바로가기 [Article Type] Meta-Analysis
ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing RoleMedicine Published on 2021-01-212022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence ACE ACE gene ACE2 activity Angiotensin II assessment case-control study conducted counterbalance COVID-19 COVID-19 disease COVID-19 patient COVID19 COVID19 pneumonia Embolism expressed genetic risk factor genetic susceptibility heterozygote high risk homozygous I/D I/D polymorphism Infection investigated involved Italy MOST Naple Occurrence Patient patients with SARS-CoV-2 pilot study Pneumonia polymorphism Population Potential Prevalence pulmonary pulmonary angiography Pulmonary embolism retrospective role Severe COVID-19 pneumonia significantly higher significantly lower single-center statistically significant difference subject thromboembolic complication Thromboembolism unit [DOI] 10.3389/fmed.2020.631148 PMC 바로가기 [Article Type] Medicine
Ethnic Prevalence of Angiotensin-Converting Enzyme Deletion (D) Polymorphism and COVID-19 Risk: Rationale for Use of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor BlockersArticle Published on 2020-09-082022-10-30 Journal: Journal of racial and ethnic health disparities [Category] COVID-19, MERS, [키워드] ACE activities acute respiratory distress African allele allele frequency Americans Analysis ANG-II angiotensin Angiotensin-converting enzyme Asian binding black blocker cohorts Comorbidity correlated COVID-19 COVID-19 incidence COVID-19 infection COVID-19 infections Deletion diabete Diabetic Ethnic European European population explain fibrosis Frequency high risk hypertension I/D I/D polymorphism Impact IMPROVE increase in Infection Inflammation insertion/deletion morbidity Mortality nephropathy obesity objective organ damage outcomes Pathologies pathway polymorphism Prevalence rationale Regression representing Result risk factor severity of COVID-19 sustained therapeutic utility USA white with COVID-19 [DOI] 10.1007/s40615-020-00853-0 PMC 바로가기 [Article Type] Article