IFITM3 – Page 2 – Communicable Diseases Research

Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020?

Covid-19 예후 및 감수성과 숙주 유전적 연관성에 대한 체계적인 검토: 2020년에 우리는 무엇을 배웠습니까?

Review

Published on 2022-03-012022-09-11
Journal: Reviews in Medical Virology [Category] SARS, 변종,

Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactions

Review

Published on 2022-02-082022-10-04
Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] ACE ACE2 acute respiratory syndrome Affect age antiviral immunity Care caused CD26 cells Characteristics contribute coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 Critical DBP Diabetes Mellitus disease Ethnic groups Factor Gender Genetic genetic diversity genetic factor Genetic polymorphism Genetic variant genetics geographical locations higher risk highly pathogenic Host host immunity human leukocyte antigen hypertension IFITM3 IL‐6 immunological reaction implication individual Inflammatory response involved knowledge mechanism men Mortality obesity Pathogenesis pathogenic mechanism pathogenicity pathologic processe pathologic processes polymorphism Population populations risk of death role SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 serological response several gene severity susceptibility the disease TMPRSS2 variant Variation virus
[DOI] 10.1002/jmv.27615 PMC 바로가기 [Article Type] Review

Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients

Research Article

Published on 2022-01-122022-10-28
Journal: Aging Cell [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS,

[키워드] age aging Analysis Antiviral C‐reactive protein Cell cell interaction cellular immunology Coronavirus disease 2019 correlated COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical D‐dimer decreased expression Defense deficiencies deficiency defined disease severity elevated epidemiological data exacerbate expression Factor IFITM3 IFNAR1 Immune cell immune response Immunity incidence individual individuals Inflammation Inflammatory marker interferon Laboratory testing LY6E Lymphocyte count macrophages molecular biology of aging morbidity and mortality naïve neutrophil–lymphocyte ratio Older pathophysiologic patients performed populations reduce reduced SARS‐CoV‐2 SARS‐CoV‐2 secretory cell severity significantly TRIM22 type I Viral load
[DOI] 10.1111/acel.13544 PMC 바로가기 [Article Type] Research Article

A systematic review on papers that study on Single Nucleotide Polymorphism that affects coronavirus 2019 severity

Research

Published on 2022-01-122022-10-28
Journal: BMC Infectious Diseases [Category] COVID-19, SARS,

Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

Immunology

Published on 2021-11-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] age Ageing analyzed Anti-viral Antiviral Asymptomatic Comorbidities COVID - 19 defensin effective expression expression pattern form forms Gender groups heterogeneous Host identify IFITM1 IFITM3 IFN - interferon IFN-I IFN-α IFN-β IFN-λ1 individual induce infected with SARS-CoV-2 Infection innate immune innate immune response Innate immunity interferon interferon-stimulated gene intrinsic LL-37 Local modulation mRNA expression mRNA level mucosa mucosal mucosal immunity nasopharyngeal nasopharyngeal mucosa Nasopharyngeal swab occur pediatric peptide Primary infection protective role Protein reached SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection selected selective subject subjects susceptibility symptomatic Symptoms the SARS-CoV-2 triggered type I type III upregulated upregulation virus β-defensin
[DOI] 10.3389/fimmu.2021.750279 PMC 바로가기 [Article Type] Immunology

A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation

Research Article

Published on 2021-10-012022-10-30
Journal: The Journal of Biological Chemistry [Category] Coronavirus, SARS,

[키워드] Acetate acetic acute respiratory syndrome Alk-12, alkynyl myristic acid or 13-tetradecynoic acid Alk-16, alkynyl palmitic acid, or 15-hexadecynoic acid Alk-3, 4-pentynoic acid Alk-4, alkynyl acetic acid or 5-hexynoic acid antiviral activity Cancer CD9 Cell cellular click chemistry contribute coronavirus CTNB1, catenin beta-1 de novo dengue virus DHHC, aspartate–histidine–histidine–cysteine disease pathogenesis DMSO, dimethyl sulfoxide Express FA, fatty acid FASN FASN, fatty acid synthase fatty Fatty acid fatty acid synthase fatty acylation FBS, fetal bovine serum function GNA1I, guanine nucleotide-binding protein, alpha inhibiting 1 HA, hemagglutinin Hepatitis hepatitis B HIV-1 HIV-1 Gag Host IFITM3 IFITM3, interferon-induced transmembrane protein 3 IFNβ, interferon beta Influenza KS6A1, ribosomal protein S6 kinase alpha labeling liver MA, matrix membrane N-myristoylation palmitate probe Prostate Protein Proteins purification Replication reporter required S-palmitoylation SAMHD1, SAM domain and HD domain containing protein 1 transmembrane protein upregulated Viral protein viruses
[DOI] 10.1016/j.jbc.2021.101272 PMC 바로가기 [Article Type] Research Article

Placental response to maternal SARS-CoV-2 infection

모체 SARS-COV-2 감염에 대한 태반 반응

Article

Published on 2021-07-132022-09-01
Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료법,

[키워드] ACE2 affected Antiviral antiviral response association Characteristics clinical parameter Clinical parameters Cohort coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 disease disease severity expression expression level furin histopathological Histopathology IFITM IFITM1 IFITM3 IgG implicated Infection late endosomes less Newborn pandemic parameter participant Pathways placental Pregnancy pregnant women Protein protein expression reported risk SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease TMPRSS2 transcripts transfer transmembrane Viral viral entry viral infection Viral protein Viral proteins women
[DOI] 10.1038/s41598-021-93931-0 PMC 바로가기 [Article Type] Article

Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality

인터페론으로 유도된 막횡단 단백질-3 유전자 변이체 rs12252는 COVID-19 사망률과 관련이 있습니다

Article

Published on 2021-07-012022-09-11
Journal: Genomics [Category] SARS, 변종, 유전자 메커니즘,

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

네트워크 의학은 SARS-COV-2/COVID-19 감염을 뇌 미세 혈관 손상 및 치매 유사인지 장애에서 신경 염증에 연결합니다.

Research

Published on 2021-06-092022-09-10
Journal: Alzheimer's Research & Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료기술,

[키워드] addition Alzheimer’s disease Alzheimer’s disease Analysis Antiviral ApoE Biomarker Blood Brain Brain microvasculature brains BSG causal relationship cell types cerebrospinal fluid change Cognitive impairment complications conducted COVID-19 CRISPR CRISPR-Cas9 Defense Dementia elevated Endothelial cell endothelial cells expression expression of SARS-CoV-2 Factor furin Genetic Guidance healthy control healthy controls help Host Human brain IFITM2 IFITM3 IFNAR1 implicated IMPROVE increasingly individual individuals infected with COVID-19 infected with SARS-CoV-2 Infection investigated lead low expression LY6E marker gene Measures mechanism microvascular injury network network medicine Neuroinflammation neurologic neurological manifestation neurological manifestations Neuron neurons overlap pathway Patient patients with COVID-19 Prevalence protein-protein interaction reduced reported responsible Result risk allele RNA-sequencing SARS-CoV-2 SARS-CoV-2 entry factor SARS-CoV-2 entry factors SARS-COV-2 infection Single-cell/nucleus supplementary material the SARS-CoV-2 transcriptomic Transcriptomic analyses transcriptomic profile transcriptomic profiles treatment interventions while
[DOI] 10.1186/s13195-021-00850-3 PMC 바로가기 [Article Type] Research

The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19

Clinical Trial

Published on 2021-03-062023-06-15
Journal: Cytokine [Category] MERS, SARS,

[키워드] antiviral protein COVID-19 genetic association IFITM3 polymorphism SARS-CoV-2
[DOI] 10.1016/j.cyto.2021.155492 PMC 바로가기 [Article Type] Clinical Trial