IL-1ra – Page 2 – Communicable Diseases Research

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza

박테리아 동시 감염 및 지속적인 호중구 기관지 폐포 염증에 대한 비정형 반응은 인플루엔자와 중요한 COVID-19를 구별합니다

Research Article

Published on 2022-01-112022-09-12
Journal: JCI Insight [Category] 진단, 치료기술,

PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response

PD-1 봉쇄는 코비드 -19 면역 이상을 반대하고 항 -SARS-COV-2 면역 반응을 자극합니다.

Research Article

Published on 2021-12-222022-08-31
Journal: JCI Insight [Category] SARS, 바이오마커,

[키워드] abnormality Alter Altered among others Anergy blockade CD8 characterized coronavirus coronavirus disease coronavirus disease-2019 counteract COVID-19 COVID-19–related symptom COVID-19–related symptoms Ex vivo healthy controls hospital discharge IL-1 IL-1 β IL-1ra IL-8 immune Immune checkpoint blockade immune response immunologically immunology Immunotherapy Infection lentivirus Methylation Neutralization assay neutralize nonspecific normalized Patient patients PD-1 PD-L1 PD1 peptides plasma Plasma level Plasma levels promoter proportion pseudotyped reduced restored SARS-CoV-2 antigens SARS-CoV-2 peptides SARS-CoV-2 spike stimulate T cell T cell response T cells
[DOI] 10.1172/jci.insight.146701 PMC 바로가기 [Article Type] Research Article

Longitudinal Cytokine Profile in Patients With Mild to Critical COVID-19

경증에서 중요한 코비드 -19 환자의 종 방향 사이토 카인 프로파일

Observational Study

Published on 2021-12-062022-08-31
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 임상,

[키워드] Administered adult COVID-19 patient adult COVID-19 patients ARDS association best Biomarker blood sample Blood samples chemokine clinical endpoint Clinical endpoints coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critically ill critically ill patients cytokine cytokine profile Cytokine release syndrome Cytokines disease severity dose early phase elevated evaluate followed by gamma interferon growth highest Hong Kong Hospitalized host response IL-10 IL-1ra IL-5 IL-6 IL-8 immune Inflammation intensive care interferon interferon-induced protein interleukin IP-10 late phase longitudinal Macrophage MCP-1 mDC mechanical ventilation MIG Mild MIP-1α moderate monocyte monocyte chemoattractant protein-1 monokine Norepinephrine observational study Patient patient group patient groups patients predict predicted profile proinflammatory prospective observational study public hospitals receptor receptor antagonist SARS-CoV-2 Seven severity symptom onset was performed with COVID-19
[DOI] 10.3389/fimmu.2021.763292 PMC 바로가기 [Article Type] Observational Study

Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity

코로나바이러스 질병 2019(COVID-19) 심각도의 바이러스 역학 및 면역 상관관계

Observational Study

Published on 2021-11-022022-09-12
Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 임상, 진단,

[키워드] age Antibody Response association Characteristics chemokine Clinical severity collected Comorbidities coronavirus 2 correlated COVID-19 Culture Cytokines disease severity Dynamics evaluated HGF IgM IgM and IgG IgM/IgG IL-12p70 IL-18 IL-1ra IL-6 immune markers immune response immune signature immunology Immunotherapy Infection Inflammatory cytokine Invasive mechanical ventilation IP-10 IQR knowledge Level MCP-1 median MIP-1α occurred offer overactive Patient PCR PCR cycle PCR-confirmed plasma sample positive proinflammatory prospective observational cohort Randomized controlled trials required respiratory respiratory sample SARS-CoV-2 SARS-COV-2 infection Seroconversion seroconverted serologic testing serology serum sample severity significantly supplemental oxygen symptom onset target threshold viability viral culture viral dynamics Viral pneumonia virus
[DOI] 10.1093/cid/ciaa1280 PMC 바로가기 [Article Type] Observational Study

Interleukin-1RA Mitigates SARS-CoV-2–Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice

Interleukin-1RA는 인간화 된 K18-HASE-2 마우스에서 SARS-COV-2- 유도 된 염증성 폐 혈관 누출 및 사망률을 완화시킨다.

10008

Published on 2021-09-092022-09-10
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] Fulltext, MERS, SARS, 바이오마커,

[키워드] activated activation of inflammasome acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Anakinra blockade cadherin caspase characterized content coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Digital Digital Content domain downregulation edema Endothelial cell endothelial cells human lung humanized Hyperinflammatory ies IL-1 IL-1 receptor antagonist IL-1ra immune response immunomodulatory therapy Infection Inflammasome Inflammatory Injury innate immune interleukin-1 junction junctions leakage lung lung edema lung endothelial Lungs mechanism mice morbidity morbidity and mortality NLR NLRP3 Prevent prevented Protein provide pyroptosis receptor receptor antagonist receptor signaling respiratory respiratory distress Respiratory distress syndrome Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Signaling significantly increased survival susceptible syndrome text Treatment Vascular Vascular injury vascular system injur VE-cadherin
[DOI] 10.1161/ATVBAHA.121.316925 PMC 바로가기 [Article Type] 10008

The Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men

Immunology

Published on 2021-08-092022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

Interleukin-18 Is a Potential Biomarker to Discriminate Active Adult-Onset Still’s Disease From COVID-19

Interleukin-18은 COVID-19에서 활성 성인 발병 스틸병을 구별하는 잠재적 바이오마커입니다

Immunology

Published on 2021-07-232022-09-11
Journal: Frontiers in Immunology [Category] SARS, 바이오마커,

[키워드] Accuracy adult-onset Still’s disease (AOSD) AUC Biomarker Biomarkers clinical feature COVID-19 COVID-19 patient cross-sectional cross-sectional study cut-off value cytokine cytokine profile Cytokine storm Cytokines determined by develop disease Diseases dysregulated elevated ELISA examined feature ferritin ferritin level galectin-3 Galectin-9 galectins healthy control highest hyperinflammation identify IFN-α2 IFN-γ IL-10 IL-17A IL-18 IL-1ra IL-1β IL-6 immunochromatographic assay Interleukin-18 multivariate regression analysis Patient patients plasma Plasma levels platform Potential predict Result SARS-CoV-2 sensitivity Seropositivity severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly significantly higher specificity TNF-α
[DOI] 10.3389/fimmu.2021.719544 PMC 바로가기 [Article Type] Immunology

Adversity in early life and pregnancy are immunologically distinct from total life adversity: macrophage-associated phenotypes in women exposed to interpersonal violence

초기 생애 및 임신의 역경은 전체 삶의 역경과 면역학적으로 구별됩니다: 대인관계 폭력에 노출된 여성의 대식세포 관련 표현형

Article

Published on 2021-07-202022-09-10
Journal: Translational Psychiatry [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] Adjusting age Anti-inflammatory anti-inflammatory cytokine CD14 CD14+ monocyte CD14+ monocytes cDNA library childhood Chronic diseases Cohort CRP cytokine Cytokines demographics early childhood early life adversity endotoxin evaluate examined exposure to Gene Expression Health Human behaviour IL-10 IL-1ra IL-1ß IL-4 IL-6 Illumina HiSeq immune immune mechanism immunologically immunosuppressive Inflammatory life Monocytes phenotype Physiology plasticity Predictive markers Pregnancy Primary outcome pro-inflammatory Psychopathology retrospective RNA sequencing seeking Sensitivity and specificity Sepsis serum severe COVID-19 socioeconomic status TNF-a Tolerance trauma Treatment women
[DOI] 10.1038/s41398-021-01498-1 PMC 바로가기 [Article Type] Article

COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively

COVID-19(SARS-CoV-2) 림프구 반응은 수술 전 총 관절 교체 수술 후보의 염증성 바이오마커와 관련이 있습니다

Research Article

Published on 2021-06-302022-09-10
Journal: Journal of Orthopaedic Surgery and Research [Category] MERS, SARS, 바이오마커, 치료법,

[키워드] addition analyzed antibodies antibody antibody production Blood candidate Cohort coronavirus COVID-19 cross-reactivity elective surgeries Elective surgery exhibited exposure to General population IgG antibodies IgG antibody IL-1ra IL-1β IL-6 Immunity Inflammatory biomarker inflammatory biomarkers joint LTT lymphocyte lymphocyte response lymphocyte responses Lymphocytes median age memory nucleocapsid nucleocapsid protein Nucleocapsid proteins parameter Patient peripheral Peripheral blood positive pre-vaccination pro-inflammatory biomarkers profiles protective immunity Protein reactive reactivity recent Registered response Result Retrospective study risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid SARS-CoV-2 virus serum spike and nucleocapsid proteins Spike protein Spike proteins T cell T cell memory the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein TNFα Total Total joint arthroplasty Trial registration vaccination vaccination Methods
[DOI] 10.1186/s13018-021-02563-7 PMC 바로가기 [Article Type] Research Article

Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection

SARS-CoV-2 감염 연구를 위한 최고의 항원 및 최고의 면역 바이오마커를 식별하기 위한 탐색적 분석

Research

Published on 2021-06-262022-09-10
Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] acute COVID-19 Analysis Antibody Response Antigen approach AUC best Biomarker Biomarkers Clinical characteristics cohorts COVID-19 demonstrated described develop diagnostics discriminant analysis Disease progression Eotaxin evaluate evaluated Factor FGF foundation G-CSF GM-CSF HCV help highest identify IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-17A IL-1ra IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 immune immune factors immune response Immunity immunogenic immunogenicity induce Infectious disease IP-10 knowledge MCP-1 membrane MIP-1α MIP-1β not affect nucleoprotein ORF3a partial least square Patient PDGF peptide peptide pool peptides RANTES recent recovered patients Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV2 SARS-CoV2 infection serological spike Spike-based vaccine spike-protein T-cell T-cell Response TNF-α Treatment strategies Tuberculosis Vaccine vaccine candidates vaccine trial VEGF Viral Viral antigen virus Whole-blood
[DOI] 10.1186/s12967-021-02938-8 PMC 바로가기 [Article Type] Research