Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses강력한 CD8 T 세포 반응에도 불구하고 손상된 체액성 면역은 장기간의 COVID-19와 관련이 있습니다Article Published on 2022-07-112022-09-11 Journal: Cancer cell [Category] COVID19(2023년), SARS, 치료법, [키워드] Affect Analysis analyzed antibody B cell B cells Cancer CD20 CD4 CD8 CD8 T cell cellular clearance convalescent COVID-19 COVID-19 infection Delayed demonstrated disease disease control dominant dysregulation effective exhibited functional highlight humoral immune response Humoral immunity immune dysregulation immune responses Impaired incidence increase in nucleocapsid Patient Patients with cancer Peripheral blood peripheral blood samples prolonged disease response rituximab robust SARS-CoV-2 SARS-CoV-2 clearance Spike protein Spike proteins T cell T cell memory T cell receptor T cell responses T cells TCR viral clearance [DOI] 10.1016/j.ccell.2022.05.013 PMC 바로가기 [Article Type] Article
Antibody and cellular immune responses following dual COVID-19 vaccination within infection-naive residents of long-term care facilities: an observational cohort studyObservational Study Published on 2022-07-012022-10-05 Journal: The Lancet. Healthy longevity [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] age antibody Antibody Response binding blood sample booster vaccination Care CD4 T-cell Cellular immune response cellular response Clinical outcome Comorbidity COVID-19 COVID-19 vaccination COVID-19 vaccine CXCL10 production Department EDTA eligible exclusion criteria Factors for inclusion frailty functional groups humoral IFN-γ IL-2 immune dysregulation immune protection immune response Impaired individual Infection IQR median median age neutralisation Observational cohort study Older participant Post-vaccine quantified response risk factor Sample SARS-CoV-2 SARS-COV-2 infection second vaccination SFU significantly staff stratified T-cell Response TNFα vaccination vaccine doses variant spike was reduced were assessed [DOI] 10.1016/S2666-7568(22)00118-0 PMC 바로가기 [Article Type] Observational Study
In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening [DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article
Symptomatic but not Asymptomatic COVID-19 Impairs Conditioned Pain Modulation in Young AdultsResearch article Published on 2022-07-012022-10-05 Journal: The Journal of Pain [Category] 바이오마커, [키워드] Asymptomatic COVID-19 condition conditioned Conditioned pain modulation Control COVID-19 COVID-19 patients CPM dominant Effect Exercise induced hyperalgesia extension First wave groups healthy control Impaired implication individual mechanism modulation not different Pain pain threshold participant performed pressure Pressure pain thresholds reported reveal sensitivity Symptom symptomatic Symptoms Vaccine was impaired were assessed were infected [DOI] 10.1016/j.jpain.2022.06.010 [Article Type] Research article
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in malesTLR3의 다형성 L412F는 자가포식을 억제하고 남성에서 심각한 COVID-19의 표지자입니다Article Published on 2022-07-012022-09-11 Journal: Autophagy [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis association autoantigen autoimmune disorder Autoimmune disorders autophagosome autophagy autophagy pathways bafilomycin clinical trial clinical trials co-morbidity Cohort coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated Diseases Frequency HEK293 cell HEK293 cells HLA HLA haplotype Hydroxychloroquine Impaired increases in Infectious diseases inhibit L412F male males marker mechanism morbidity Necrosis Plasmid poly(I:C) polymorphism provide Rapamycin rationale receiver operating characteristic receptor reduced respiratory risk severe acute respiratory syndrome Coronavirus severe COVID-19 severity shown statistically significant stimulated sub-cohort survival TLR3 TNFα transfected with treated Tumor tumor necrosis tumor necrosis factor [DOI] 10.1080/15548627.2021.1995152 PMC 바로가기 [Article Type] Article
Long COVID: Association of Functional Autoantibodies against G-Protein-Coupled Receptors with an Impaired Retinal Microcirculation긴 COVID: 손상된 망막 미세순환을 가진 G-단백질 결합 수용체에 대한 기능적 자가항체의 연관성Article Published on 2022-06-292022-09-12 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome acute SARS-CoV-2 infection autoantibody Autoimmune blood flow Chronic fatigue chronic fatigue syndrome clinical phenotype Clinical symptoms complex interplay controls coronavirus COVID COVID-19 Factor female functionally GPCR autoantibodies Glaucoma Healthcare system Impaired Infection Long long-COVID syndrome mechanism Microcirculation OCT–angiography Patient peripapillary previous study quantified receptor Retinal SARS-CoV-2 SARS-COV-2 infection significant decrease statistical analysis Symptom therapeutic option vessel was measured [DOI] 10.3390/ijms23137209 PMC 바로가기 [Article Type] Article
Impaired Kallikrein-Kinin System in COVID-19 Patients’ SeverityObservational Study Published on 2022-06-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Accuracy ACE2 Admission analyzed Bradykinin (BK) C1 esterase inhibitor cascade characterized clinical laboratory Coagulation Combination Concentration consecutive patient control group COVID-19 CPN1 cutoff value D-dimer D-dimer level disease disease severity dysregulated dysregulation enzyme Factor healthy subject ICU ICU admission Impaired independent independent predictor Inflammation intensive care involved Kallikrein-kinin system KLKB1 lymphopenia multivariate multivariate logistic regression multivariate model NLRP3 NLRP3 inflammasome Observational cohort study Odds ratio pathophysiology patients with COVID-19 peptide plasma concentration plasma protein Protein reported retained Severe COVID-19 pneumonia severity subunit System Thromboinflammation vascular homeostasis was related [DOI] 10.3389/fimmu.2022.909342 PMC 바로가기 [Article Type] Observational Study
Recurrent SARS-CoV-2 Infection and Impaired Immunologic Response in a Pediatric Oncologic Patient While Treated With Radiochemotherapy방사선화학요법을 받는 동안 소아 종양 환자의 재발성 SARS-CoV-2 감염 및 면역학적 반응 손상Case Reports Published on 2022-06-012022-09-12 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome affected analyzed Anti-viral coronavirus IgG levels Immunologic Impaired Infection Intensive malignant disease Pediatric patient Recurrent response responses SARS-CoV-2 SARS-COV-2 infection T-cell therapy while [DOI] 10.1097/INF.0000000000003515 PMC 바로가기 [Article Type] Case Reports
Impaired SARS-CoV-2 mRNA Vaccine Antibody Response in Chronic Medical Conditions: A Real-World Analysis만성 의학적 상태에서 손상된 SARS-CoV-2 mRNA 백신 항체 반응: 실제 분석Article Published on 2022-06-012022-09-12 Journal: Chest [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] chronic Impaired mRNA response SARS-CoV-2 [DOI] 10.1016/j.chest.2021.12.654 PMC 바로가기 [Article Type] Article