Synthesis of new Spiropyrazole derivatives under microwaves irradiation and docking study for inhibition the microbes and COVID-19Research article Published on 2022-12-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 6LU7 addition analysis antimicrobial Antiviral binding Candida albican Complete Complexes COVID-19 derivative derivatives docking docking score docking study domain Effectiveness Hydrazonoyl halides indicated inhibit Interaction Laboratory microbe microwave Microwaves physicochemical property protease Seven Spiropyrazoles synthesis tested these compound with COVID-19 [DOI] 10.1016/j.molstruc.2022.133581 [Article Type] Research article
Evaluation of humoral immune responses induced by different SARS-CoV-2 spike trimers from wild-type and emerging variants with individual, sequential, and combinational delivered strategiesArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Antibody Response antibody response against autologous binding circulating coronavirus coronavirus disease COVID-19 Delta effective heterogenous homologous humoral immune response immunization immunogenicity indicated induce monovalent vaccine multivalent vaccine neutralizing antibody Neutralizing antibody response omicron produced regimen SARS-CoV-2 SARS-CoV-2 spike trimer significantly spike Spike protein spike trimer strain supported trimer Vaccination strategies Vaccination strategy Vaccine Vaccines variant Variant. variants viruses wild type wild-type [DOI] 10.1002/jmv.28081 PMC 바로가기
Can torque teno virus be a predictor of SARS-CoV-2 disease progression in cancer patients?Article Published on 2022-12-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysed association Can Cancer cancer patient Cancer patients clinical manifestation Control control subjects controls correlation COVID-19 death deficiency demonstrated detectable died DNA immune system indicated Infection Nasopharyngeal swab outcomes patients with SARS-CoV-2 previous study progression Retrospective study SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 RNA SARS-CoV-2-positive patients significantly lower statistically significant subjects survival rate torque Torque teno virus. Viral load virus was related [DOI] 10.1016/j.jiac.2022.08.015 PMC 바로가기
Immunogenicity and reactogenicity after heterologous prime-boost vaccination with CoronaVac and ChAdox1 nCov-19 (AZD1222) vaccinesCoronaVac 및 ChAdox1 nCov-19(AZD1222) 백신으로 이종 프라임-부스트 백신 접종 후 면역원성 및 반응성Article Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, 진단, [키워드] 95% CI 95% confidence interval Administered age age and sex antibody assigned AZD1222 binding domain booster dose Care ChAdOx1 nCoV-19 Cohort cohorts Combination Concentration control group CoronaVac COVID-19 COVID-19 pandemic effective elicited enrolled finding geometric mean ratio GMR Health Heterologous heterologous prime-boost homologous immune response immunogenicity indicated mass participant primary endpoint prime-boost interval RBD reactogenicity robust Safe the median vaccination Vaccine vaccine administration vaccine combination. while [DOI] 10.1080/21645515.2022.2052525 PMC 바로가기 [Article Type] Article
One-click investigation of shape influence of silver nanostructures on SERS performance for sensitive detection of COVID-19Article Published on 2022-11-222022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] Ag nanostructure approach Concentration COVID-19 dendritic Diagnosis Diseases indicated investigated magnitude Microdroplets array Mini-pillar platform morphology multiple parameter Novel coronavirus provide reproducibility RNA sequence SARS-CoV-2 sensitive sensitivity SERS. the SARS-CoV-2 transfer [DOI] 10.1016/j.aca.2022.340523 PMC 바로가기
COVID-19 vaccine hesitancy in periconceptional and lactating women: a systematic review and meta-analysis protocolArticle Published on 2022-11-072022-11-16 Journal: BMJ Open [Category] meta-analysis, [키워드] Analysis appear approval article caused CNKI Cochrane Library COVID-19 COVID-19 vaccine criteria data extraction determinant discrepancy disease effective Embryology Epidemiology Ethics Evidence gestation heterogeneity higher risk homogeneous indicated lack lactating lactating women lactation Meta-analysis meta-regression observational study outcome outcomes pandemic pandemic of COVID-19 peer-reviewed Pregnancy pregnant pregnant women Prevalence PROSPERO protocol provided receive reproductive Reproductive medicine. required Research resolved subject systematic review vaccination Vaccine hesitancy Web of Science WHO with COVID-19 women [DOI] 10.1136/bmjopen-2021-059514 PMC 바로가기
Perceived feasibility, facilitators and barriers to incorporating point-of-care testing for SARS-CoV-2 into emergency medical services by ambulance service staff: a survey-based approachArticle Published on 2022-11-032022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] Accuracy acquisition ambulance service Analysis approach assessments assistant Care Characteristics clinical decision clinical utility collected COVID-19 criteria current elicit Emergency emergency situation facilitator feasibility feasible Follow-up healthcare services indicated Lateral flow device majority medical service molecular diagnostics Perceived point-of-care qualitative data Qualitative research. rapid SARS-CoV-2 testing required response risk stratification SARS-CoV-2 SARS-CoV-2 test Sensitivity and specificity supported survey to define unlikely while [DOI] 10.1136/bmjopen-2022-064038 PMC 바로가기
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기
Air quality in Germany as a contributing factor to morbidity from COVID-19Observational Study Published on 2022-11-012022-10-05 Journal: Environmental research [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI age Air pollution ambient association Care conducted COVID-19 COVID-19 case COVID-19 incidence defined European Environment Agency functions Germany health parameters IMPROVE incidence indicated intensive care Intensive care medicine Mechanical mechanical ventilation morbidity Mortality mortality rate nitrogen nitrogen dioxide nitrogen monoxide outbreak outcome public health ranged reduce risk factor Robert Koch SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2. Sex statistical significance susceptibility with COVID-19 [DOI] 10.1016/j.envres.2022.113896 PMC 바로가기 [Article Type] Observational Study
Occurrence and distribution of azithromycin in wastewater treatment plants, seawater, and sediments of the northern part of the Persian Gulf around Bushehr port: A comparison with Pre-COVID 19 pandemicResearch article Published on 2022-11-012022-10-05 Journal: Chemosphere [Category] 변종, 치료기술, 치료제, [키워드] adjusted Antibiotic resistance Antibiotics assumed Azithromycin Bushehr collected Concentration Contamination COVID 19 COVID 19 patients disease distribution ecosystem Effect Efficiency evaluate growth Hypothesis indicated investigated less observation pandemic Persian gulf plant plants Seawater treat Treatment Variation variations Wastewater treatment plants [DOI] 10.1016/j.chemosphere.2022.135996 [Article Type] Research article